Euquimol Nadyphar powder treatment for fever, weather allergy, sneezing, stuffy nose (3g x 30 packs)
Dosage form Box of 30 packs x 3g
Specifications Paracetamol, phenylephrine, chlorpheniramine
Ingredient
| Composition information | Content |
| Paracetamol | 160mg |
| Phenylephrine | 2.5mg |
| Chlorpheniramine | 1mg |
Uses
indications
EUQUIMOL drugs are indicated in the following cases:
Treatment of fever, weather allergies, sneezing, nasal congestion in children.
Pharmacokology
paracetamol
Paracetamol (N - Acetyl - P - Aminophenol) is a metabolic product that has the activity of phenacetin, has an analgesic effect - antipyretic and can replace aspirin, however, unlike aspirin, paracetamol is not effective for inflammatory treatment. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to Aspirin.
Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on body cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time.
phenylephrin hydrochloride
Phenylephrin hydrochloride is a sympathetic nerve -like effect, which directly works on the receptors α - adrenergic as a vasoconstriction, which reduces nasal congestion and sinuses due to colds.
chlorpheniramin
Clorpheniramin Maleat is an antihistamine with very little sedative effects. Anti -antihistamine effects through the block of composition of H1 receptors, of the acting cells. Used to treat allergic rhinitis, urticaria, vasculitis caused by histamine, allergic conjunctivitis, contact dermatitis, angioedema, rhyme ...
pharmacokinetics
paracetamol
absorption
The type of oral oral drug is absorbed quickly, completely. The drug is weak with plasma protein to reach the maximum concentration after 30-60 minutes.
Distribution
Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.
Metabolism, excretion
Semi -canceling time in plasma from 1.25 - 3 hours.
paracetamol metabolized in the liver, excreted in the urine in the form of: combined with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%) and a small amount of hydroxylation and reducing substances. Paracetamol is metabolized under the effect of cytochrom P450 into metabolic, quickly reduced by glutathion and toxic due to increased metabolites when high doses.
phenylephrin hydrochloride
absorption
Phenylephrin is very abnormal through the gastrointestinal tract due to being metabolized right on the digestive tract. After drinking, the anti -congestion effect appears within 15-20 minutes, and lasts 2-4 hours.
Distribution
Phenylephrin may be distributed into tissues, but it is not known whether the drug can be distributed into breast milk.
Metabolism, excretion
Phenylephrin is metabolized in the liver and the intestinal liver thanks to the enzyme monoaminoxidase (Mao). What are the metabolites that have not yet been identified, so it is unknown to the metabolic path and the waste speed of phenylephrin.
chlorpheniramin maleat
absorption
Good absorption when drinking, appearing in plasma after 30-60 minutes. The peak concentration in plasma reaches after 2.5 to 6 hours after drinking. The drug has low bioavailable drugs, reaching 25-50%.
Distribution
About 70% of the drug during the circulation is linked to the protein. The distribution is 3.5 l/kg (adults) and 10 l/kg (children).
Metabolism, excretion
chlorpheniramin maleat is fast and highly metabolized. The metabolites include: Desmethyl - Didesmethyl - Clorpheniramin and some unknown substances. The excreted drug is mainly in the urine in the form of constant or metabolic. The excretion depends on pH and urine flow. A small amount of excretion in feces. Disease time 12 - 15 hours, in people with chronic renal failure lasts up to 280 - 330 hours.
Before taking Euquimol Nadyphar powder treatment for fever, weather allergy, sneezing, stuffy nose (3g x 30 packs)
How to use
Mix powder in water before drinking.
Dosage
Children 2 - 6 years old: Take 1 pack/time, 3-5 times a day.
Children 6 - 12 years old: Take 2 packs/time, 3-5 times
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?
Symptoms
Paracetamol poisoning may be due to a single -dose, or due to a large dose of paracetamol (for example: 1.5 - 10 g per day, for 1-2 days), or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.
When an overdose of paracetamol, a metabolic substance is N - Acetylbenzoquinonimin, which is toxic to the liver.
Excessive dose can cause liver cell decomposition, metabolic acidosis, brain pathology leading to coma.
Handling
Gastric lavage (preferably within 4 hours after drinking). The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the supplementation of glutathion reserves in the liver, N - acetylcystcin, which works when taken or intravenous. Must give the drug immediately if less than 36 hours after taking paracetamol.
Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcysteine at the first dose of 140 mg/kg, then give 17 more doses, each dose of 70 mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.
Can use methionin, activated carbon and/or salt bleach because they have the ability to reduce the absorption of paracetamol.
involves phenylephrin hydrochloride
Symptoms
Overdose of phenylephrin increases blood pressure, headache, convulsions, brain hemorrhage, chest drum, extra -collection, and paresthesia. Slow heart rate usually occurs early.
Handling
Hypertension can be overcome by taking α -adrenergic blockers like phentolamine 5 - 10 mg, intravenously; If necessary, can be repeated. Hemorrhage is usually not helpful. Pay attention to symptomatic treatment and general support, medical care.
related to chlorpheniramin maleat
Dosage of chlorpheniramine is about 25 - 50 mg/kg body weight.
Symptoms
Sediment, inverse stimulation often central nervous system, mental rebellion, seizure, apnea, convulsions, anti -secretion effects Acetylcholin, hypertonic reaction and cardiovascular collapse, arrhythmia.
Handling
Symptomatic treatment and support for living functions, paying special attention to liver, kidney, respiratory, heart and water balance, electrolyte.
Stomach or vomiting with ipecacuanha syrup. Then, for active carbon and bleach to limit absorption.
When hypotension and arrhythmia, should be actively treated. It is possible to treat convulsions with intravenous diazepam or phenytoin intravenously. May have to be blood transfusion by heavy cases.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using EUQUIMOL drugs you may experience unwanted effects (ADR).
Common, ADR> 1/100
Uncommon, 1/1000 Hypertension with pulmonary edema, arrhythmia, slow heart rate, peripheral vasoconstriction and organs reduces bloating for organs, respiratory failure, hallucinations, paranoia, releasing eye pigment particles, fading cornea. Rare, ADR Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
EUQUIMOL drugs contraindicated in the following cases:
Be cautious when using
Caution with anemia patients before. Impaired liver or kidney function.
Drink plenty of alcohol, beer can increase the toxicity of paracetamol to the liver.
Doctors need to warn the patient about signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).
The risk of respiratory complications, respiratory decline and apnea. Must be cautious when chronic lung disease, shortness of breath or shortness of breath.
Not used simultaneously with sedatives causing sleep or drinks with ethanol because it can increase the central nervous inhibition effect.
Be cautious when used for patients with hyperthyroidism, slow heartbeat, partial heart disease, myocardial disease, severe arteriosclerosis, diabetes type 1.
The ability to drive and operate machinery
to avoid use because the drug can cause dizziness, dizziness, blurred vision and mental impairment.
Pregnancy
only use drugs for pregnant women when really necessary, consider harmful effects caused by drugs.
Lactation period
Clorpheniramin can be secreted through breast milk and inhibit milk secretion. Because the drug belongs to the antihistamine group can cause serious response to breastfed babies, it is necessary to consider or not breastfeed or do not take the drug, depending on the weight of the drug for the mother.
Drug interaction
related to paracetamol
Concentrated anti -convulsed drugs (Phenytoin, Barbiturat, Carbamazepin), Isoniazid increases the toxicity of the liver.
Long -doses of high -dose Paracetamol increases the anticoagulant effects of cooumarin and indoors. This effect is small or not clinically important, so paracetamol is used when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin and indandion derivatives.
Regarding chlorpheniramin maleat
Monoamine oxydase inhibitors (Mao) prolonged and increased anti -secretion effects of antihistamine drugs.
ethanol or sedative drugs can increase the central nervous system inhibiting the central nervous system of chlorpheniramin.
chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.
Regarding phenylephrin hydrochloride
Not used with bromOriptin, Mao inhibitors, epinephrin or other sympathetic drugs.
Be cautious while taking 3 -round antidepressants, guanthidin, Atropin sulfate, mushroom mushroom, digitalis, furosemid, pilocarpin.
Storage
At a temperature not exceeding 30 ° C, avoiding light.
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