Evadays Vaginal 500mg Mediplantex Treatment of vaginitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazole, neomycin, nistatina

Ingredient

Composition information	Content
Metronidazole	500mg
Neomycin	65000iu
Nistatina	100000iu

Uses

indications

Evadays drugs are indicated in the following cases:

Treatment of bacterial vaginosis, sensitive fungi: Gardnerella Vaginalis, Trichomonas Vaginalis, Candida Albicans ...

Treatment of contaminated vaginitis at the same time Trichomonas and yeast.

metronidazol:

is a very strong drug in the treatment of primeval animal infections such as Entamoeba Histolytica, Giardia Lamblia and Trichomonas Vaginalis. Metronidazole has bactericidal effects on bacteroides, fusobacterium and other mandatory anaerobic bacteria, but does not have the effect on narrow bacteria. Metronidazole is only resistant to a few cases.

However, when using Metronidazol alone to treat Campylobacter or Helicobacter pylori, the drug resistance is growing quite quickly.

When infected with both anaerobic and anaerobic bacteria, Metronidazole must be combined with other antibacterial drugs.

When bacterial/vaginal infections, metronidazol, will cause the vaginal bacteria to return to normal in the majority of patients who use Metronidazol drugs that do not affect the normal bacteria in the vagina.

neomycin sulfate:

Neomycin Sulfate is an aminoglycosid antibiotic, which works with Gram -negative and gram -positive bacteria that cause skin infections.

Bacteria sensitive to Neomycin Sulfate: Escherichia Coli, Haemophilus Influenzae, Klebsiella, Entobacter of all kinds, neisseria of all kinds.

Neomycin does not work with Pseudomonas Aeruginosa, Serratia Marcescens, Streptococci including Streptococcus Pneumoniae or Streptococcus.

nystatin:

Nystatin is an anti -fungal antibiotic extracted from streptomyces noursei mushroom culture.

Nystatin has the effect of restraining or killing fungi depending on the concentration and sensitivity of the fungus, does not affect the normal bacteria on the body. The most sensitive is the yeast and has a very good effect on Candida Albicans.

The drug has the mechanism of acting as a link with the sterol of the cell membrane sensitive fungi, so nystatin changes the permeability of the mushroom membrane. Nystatin tolerates well even when long -term treatment and does not cause drug resistance.

pharmacokinetics

metronidazol

absorption: Metronidazole reaches a plasma concentration of about 10 mcg/ml about 1 hour after taking 500 mg. The absorption of Metronidazol when using the vagina is half when taken if taken in the same dose.

Distribution: about 10 - 20% of the drug is associated with plasma proteins. Metronidazole penetrates well into tissues and fluids, into saliva and breast milk. The concentration of treatment is also achieved in cerebrospinal fluid.

Metabolism: metronidazole metabolizes the liver into hydroxy and acid metabolites, and eliminates through urine partially in the form of glucuronid.

Elimination: Metronidazol's semi-discharged time in plasma is about 8 hours and an integral distribution of the water volume in the body (0.6-0.8 liters/kg).

neomycin sulfate

absorption: poor absorption through the gastrointestinal tract, about 97% of oral dose is excreted in the form of unchanged in feces. After taking 3 grams, the serum peak concentration reaches about 4 micrograms/ml and when the drug is absorbed. Absorption of drugs can increase when the mucosa is inflamed or damaged.

Elimination: The drug is rapidly eliminated through the kidneys. The sale time of the drug is 2-3 hours. The drug is often used on the spot to treat infections.

nystatin

Do not absorb through the skin or mucosa when used on the spot, excreted mainly in the form of unprover.

Before taking Evadays Vaginal 500mg Mediplantex Treatment of vaginitis (1 blister x 10 tablets)

How to use

Evadays tablets are used to place vagina. Before placing, rinse the vagina, dip the tablet wet with boiling water to cool. Place deep into the vagina every night before going to bed. After placing, lie about 15 minutes.

Dosage

Common dose: 1 tablet on 1 consecutive use for 10 to 15 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

Symptoms: Nausea, vomiting, loss of air conditioning, toxic symptoms with kidney or hearing.

Treatment: monitor kidney function and hearing. If these functions are impaired, the hemorrhage. Necessary can give prolonged respiration.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Evadays you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: itching, urticaria, blushing.

Uncommon, 1/1000

Liver: Increase liver and bilirubin.

blood: hematopoiia, hemolytic anemia, leukopenia.

Saliva glands: Increased salivation.

rare, ADR

Reaction on the spot: itching, vaginal redness, on -site irritation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

EVADAYS drug is contraindicated in the following cases:

Do not drink.

Hypersensitivity to Metronidazol or other nitro-imidazol conductors ..

sensitive to nystatin.

Hypersensitivity to neomycin or aminoglycosides.

Pregnant women.

Be cautious when using

Caution with people with impaired liver and kidney function.

Metronidazole has the effect of inhibiting alcoholhehydrogenase and other alcohol oxidation enzymes. Should be cautious when drinking alcohol during medication.

Neomycin can cause respiratory inhibitors.

Be cautious when taking long -term drugs.

The ability to drive and operate machinery

Patients using drugs should be cautious when driving or operating machinery.

Pregnancy

Do not take medication.

Breastfeeding period

Should stop breastfeeding when taking the drug.

Drug interaction

lost the resistance to Candida Albicans if used simultaneously with riboflavin phosphate.

Metronidazole increases the effects of anticoagulant drugs so avoiding use at the same time.

Take medication simultaneously with strong diuretic such as Ethacrynic, Furosemid increases the ability to poison the kidneys and hearing.

The drug can reduce the absorption of phenoxyl penicilin, digoxin when used simultaneously.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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