Evaldez 50 Davipharm medicine for depression (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Levosulpid

Ingredient

Composition information	Content
Levosulpid	50mg

Uses

Indications

Evaldez 50mg drugs are indicated in the following cases:

Reduce the symptoms of indigestion function: bloating, upper abdomen, heartburn, belching, nausea, vomiting.

Acute and chronic psychiatric treatment. Levosulpidi can be considered as an intermediate medication between neuroleptic and antidepressants, because Levosulpides have both of those effects.

pharmacokinetic pharmacokinetics

absorption

Drugs slowly absorbed through the gastrointestinal tract, low bioavailability and depending on the individual. The peak concentration reaches 3 - 6 hours after taking 1 dose.

Distribution

Quickly distributed into the tissue, through breast milk but through the blood -brain barrier. The drug is associated with low plasma proteins (

Metabolism and elimination

Eliminating drugs through urine and feces, mainly in the form of unprovered (about 95%). Selling time is about 8 - 9 hours.

Before taking Evaldez 50 Davipharm medicine for depression (6 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults

Reduce the symptoms of indigestion function: 75 mg/ day, divided 3 times.

Acute and chronic psychiatric treatment: 200 - 300 mg/ day, divided 3 times.

Children over 14 years old: reduce the dose.

Children under 14 years of age: No indications.

Renal failure

Must reduce the dose or increase the distance between drug use depending on the clearinine clearance.

Creatinine clearance 30 - 60ml/minute: use the dose equal to 2/3 of the normal dose.

Creatinine clearance 10 - 30ml/ minute: Take the dose equal to 1/2 of normal dose.

The clearance of less than 10ml/minute: taking the dose equal to 1/3 of the normal dose. Or may increase the distance between the doses is 1.5, 2 and 3 times compared to normal people. However, in case of medium and severe renal failure should not use levosulpid.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

Common when used from 1 to 16 g, but no death even at a dose of 16 g. Clinical symptoms vary depending on the dose. The dose of 1 - 3 g can cause a state of gloomy, restlessness and rare symptoms. The dose of 3 - 7 g can cause more excitement, confusion and more foreign tower syndrome. With a dose of over 7 g, in addition to the above symptoms can also have coma and hypotension. In general, symptoms are usually lost within hours. The state of coma encountered when using high doses can last up to 4 days.

Handling

Levosulpidi has no specific antidote. Therefore, if you are new to medication, you should wash your stomach, drink activated carbon (the medicine does not work), alkaline urine to increase the discharge. If necessary, Parkinson's syndrome can be used and use other supportive treatments and treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Evaldez 50 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: insomnia or drowsiness.

Endocrine: increased blood prolactin, increased milk secretion, menstrual disorders or amenorrhea.

Uncommon, 1/1000

Neurological: excessive stimulation, extracurricular syndrome (restless sitting, crooked neck), Parkinson's syndrome.

Heart: extended qt range (causing arrhythmia, torsion).

Rare, 1/10,000

Endocrine: Big breasts in men.

Neurological: late movement, malignant high fever syndrome due to neuroleptic.

Blood pressure: Hypotension, slow heart rate or arrhythmia.

Other: Lower body heat, sensitive to light, jaundice due to stasis.

Instructions on how to handle ADR

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Evaldez drugs 50mg contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

adrenal oral tumor.

Acute porphyrin metabolism disorders.

The central nervous state is inhibited, comatose, alcohol poisoning and neurological inhibitors.

Be cautious when using

In cases of renal failure, levosulpidi dose is needed and increased monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy and capable of lowering the threshold of seizures are lowered.

Elderly: because it is easy to lower blood pressure, sleepy and susceptible to extras.

People who drink alcohol or are taking alcohol medications and increasing drowsiness, high fever with unknown reasons: It is necessary to stop the drug to eliminate malignant neuroleptic syndrome.

People with mild mania, low -dose levosulpids can cause severe symptoms.

To be out of reach of children.

The ability to drive and operate machines

Patients may have dizziness or neurological disorders when taking the drug. Therefore, be careful when driving and operating machinery.

Pregnancy

Similar to other neuroleptic drugs, Levosulpidi through the placenta can cause unwanted effects on the fetus's nerves, so it should not be used during pregnancy, especially in the first 16 weeks.

Breastfeeding period

levosulpidi allocated into breast milk in relatively large amounts and may cause unwanted reactions for breastfed babies. Therefore, women who are breastfeeding should not be used or stop breastfeeding if taking the drug.

Drug interaction

Sucralfat or antacids containing aluminum - Magnesi Hydroxyd: Reducing the absorption of levosulpides, so it is recommended to use Levosulpidi after taking antacids for about 2 hours to avoid interaction.

lithium: Increasing the likeliological disorder of Levosulpidi can be caused by lithium, increasing the ability to attach levosulpides to Dopaminergic D receptors in the brain.

Levodopa: Antagonism competes with levosulpides and sedative drugs, so contraindicated coordination of levosulpidi with levodopa.

alcohol: increase the sedative effect of the drug, so avoid drinking alcohol and alcoholic drinks while taking levosulpides. Machinery, so it should be noted when coordinated.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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