Ezdixum 40mg Medisun treatment for gastric ulcer, duodenum, gastroesophageal reflux disease, severe esophagus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Esomeprazol

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

indications

Ezdixum drug indicated in the following cases:

Stomach-colonial ulcer has helicobacteri pylori.

Zollinger-Ellison syndrome. Omprazole works to reduce the secretion of stomach acid with a specialized mechanism of action. The drug is a specific inhibitor in the acid pump in the wall of the stomach.

Mechanism of stagnation: Esomeprazole is a weak base, focused on transforming into an active form in a high acidic environment in the submachine of the cell's secretion, where H+/ K+ - ATPase inhibitors (proton pumps), thus inhibit both basic fluid and stimulating fluid.

pharmacokinetics

absorption and distribution:

Esomeprazole absorbs quickly after drinking, reaching the highest concentration in plasma after 1-2 hours. Esomeprazole's bioavailability increases according to the dose and when used to repeat, reaching about 68% when taking the dose of 20mg and 89% when taking the dose of 40mg. The food slows down and reduces the absorption of Esomeprazole, although this does not significantly affect the effects of Esomeprazole on the secretion of stomach acid.

About 97% Esomeprazole attaches to plasma proteins. The volume of distribution when the drug is stable in healthy people is 16 liters.

Metabolism and elimination:

Esomeprazole is completely transformed through Cytochrom P 450 (CYP) system. The main part of the Esomeprazole metabolism depends on the morphological CYP2C19 enzyme, forming hydroxy and desmethyl metabolites that are no longer active in Esomeprazole. The rest of the metabolic process depends on another specific homogeneous substance, CYP3A4, forming Esomprazole Sulphone, plasma main metabolites.

When used repeated, initially metabolized through the liver and the clearance of the drug reduced, possibly due to the inhibited isoenzyme CYP2C19. However, there is no drug accumulation when used once a day. In some people because of the lack of CYP2C19 due to genetics (15-20% of Asians), they should slow down the metabolism of Esomeprazole, resulting in a 2-time increase in AUC value compared to people with enough enzymes.

Sell waste time in plasma 1.3 hours after the dose is repeated once a day. The main metabolites of Esomeprazole do not affect the secretion of stomach acid. About 80% of Esomeprazole oral doses are eliminated in urine in the form of metabolites, the rest through feces. Under 1% of the mother is eliminated in the urine. In people with severe liver failure, AUC value is in a state of stability 2-3 times higher than people with normal liver function so it is necessary to reduce the dose of Esomeprazole in these patients, the dose does not exceed 20mg a day.

Esomeprazole pharmacokinetics in people under 18 have not been studied.

Before taking Ezdixum 40mg Medisun treatment for gastric ulcer, duodenum, gastroesophageal reflux disease, severe esophagus (3 blisters x 10 tablets)

How to use

EZDIXUM drug orally before eating at least 1 hour, swallow all capsules, do not chew or crush the cysts. For patients who are difficult to swallow, it is possible to separate follicles and mix pellet seeds with yogurt or smoothie for easy swallowing.

Dosage

Adults and adolescents aged 12 and older:

Severe gastric gastroesophageal disease:

Treatment of gastroesophageal reflux disease with esophagitis: 40mg Esomeprazole, 1 time/day for 4-8 weeks, can take 4-8 weeks more if there are still symptoms or manifestations of endoscopic inflammatory inflammation.

Treatment of peptic ulcer has Helicobacter pylori:

Esomeprazole is a treatment of treatment regime along with antibiotics, for example, a combination treatment regimen of 3 components: Amoxicillin 1g x 2 times/day, Clarithromycin 500mg x 2 times/day with Esomeprazole 40mg x 1 time/day DAGNF for 10 days.

Treatment of Zollinger syndrome - Ellison:

The recommended starting dose is Esomeprazole 40mg, 1 time/day. Then adjust the dose according to the response of each patient and continue treatment when it is indicated clinically. When the daily dose is greater than 80mg, the dose should be spent 2 times/day

Children under 12 years old:

Do not use Esomeprazole for children under 12 years old because there is no data.

People with kidney function:

No need to adjust the dose for patients with mild and medium liver failure. Esomeprazole dose for patients with severe liver failure must not exceed 20mg/day

Elderly:

No dose adjustment in the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The described symptoms related to the use of 280mg dose are symptoms on the gastrointestinal tract and fatigue. Esomeprazole 80mg single doses are still safe to use. There is no specific detox. Esomeprazole is strongly attached to plasma proteins and therefore not easy to fertilize. In case of overdose, symptomatic treatment and use of general support measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Overall, Esomeprazole tolerates well when used in a short time or a long time.

Common (ADR> 1/100):

Systemic: headache, dizziness, skin extra skin.

Body: fatigue, insomnia, drowsiness, rash, itching, visual disorders.

Rare (ADR Body: Fever, sweating, peripheral edema, sensitivity to light, hypersensitivity reactions (including urticaria, angioedema, bronchospasm, anaphylactic shock). Hepatitis, hepatitis, jaundice, liver function. can increase the risk of bacterial infections in the gastrointestinal tract.

Must stop the drug when there is an unwanted effect.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

EZDIXUM drug contraindicated in the following cases:

Severe liver failure.

Caution when using

when there is any warning symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or black defecation) and when suspected or gastric ulcer should eliminate malignant diseases because Esomeprazole treatment can reduce symptoms and delay diagnosis.

Patients treated according to the regime when necessary should contact the doctor if there are symptoms that change in characteristics. When prescribing Esomeprazole according to the treatment regime when necessary, it is advisable to consider the interaction associated with other drugs due to the concentration of Esomeprazole in the blood that can change (see drug interaction).

When prescribing Esomeprazole to eradicate Helicobacter pylori, it is advisable to consider the rules that may occur in the 3 -drug treatment regimen. Clarithromycin is a strong CYP3A4 inhibitor and therefore should consider contraindicated and interact with Clarithromycin when using a 3 -drug regimen for people who are taking other drugs metabolized through CYP3A4.

Proton pump inhibitors can slightly increase the risk of gastrointestinal infections caused by Salmonella and Campylobacter.

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Using drugs for women during pregnancy and lactation

Pregnancy:

There is no clinical data on the use of Esomeprazole in pregnant women. So only use drugs for pregnant women when really necessary.

Breastfeeding period:

The excretion of Esomeprazole in breast milk has not been studied. Because Esomeprazole has the ability to excrete on breast milk, deciding to stop breastfeeding or stopping the drug. Should calculate the importance of the drug for the mother.

Interactive drug

Due to the inhibition of acid excretion, Esomeprazole increases the stomach pH, affecting the bioavailability of the absorbing drugs depending on the pH: ketoconazole, iron salt, digoxin.

Simultaneous use of Esomeprazole, Clarithromycin and Amoxicillin increases the concentration of ecomeprazole and 14-hydroxyclarithromycin in the blood.

Esomeprazole interact with pharmacokinetic pharmacokinetic drugs with metabolic drugs by the cytochrom P450 enzyme system, isoenzyme CYP2C19 in the liver. Simultaneous use of Esomeprazole and Diazepam reduces 45% of Diazepam's clearance.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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