Ezinapc Ampharco medicine for allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Cetirizine

Ingredient

Composition information	Content
Cetirizine	10mg

Uses

indications

Ezinapc is indicated for treatment in the following cases:

Seasonal allergic rhinitis and persistent allergic rhinitis: Ezinapc (Cetirizin) is indicated that reduces the symptoms of seasonal allergic rhinitis and persistent allergic rhinitis caused by allergens such as pollen, dust, animal hair and mold. Effective treatment symptoms include sneezing, runny nose, posterior nose, itchy nose, itchy eyes, watery eyes and red eyes in adults and children 6 years of age or older. The drug significantly reduces the appearance, severity, and time of rash, and also significantly reduces itching.

Allergic conjunctivitis: Ezinapc (Cetirizin) is indicated that reduces the symptoms of allergic conjunctivitis such as itchy eyes, watery eyes and red eyes in adults and children aged 6 and older.

Code ATC: R06AX26

Cetirizin is a powerful antihistamine that has an anti -allergy effect, but does not cause drowsiness at the pharmacological dosage.

Cetirizin has a selective antagonistic effect in H's receptor, and the effect on other receptors is negligible, so there is almost no antagonistic effect acetylcholin and no serotonin antagonistic effect. Cetirizin inhibits the "early" stage of allergic reactions through histamine intermediaries and also reduces the relocation of inflammatory cells and reduces the release of intermediate substances at the "late" stage of allergic reactions.

pharmacokinetics

The drug is absorbed quickly after drinking. The concentration of the equilibrium measurement is 0.3 mcg/ml, achieving the pharmacy after 1.0 + 0.5 hours. Oral bioavailability does not change when taking the drug with food. The volume
the apparent distribution is 0.50 liters/kg. The ratio of binding with plasma proteins is 90 - 96%.

About 2/3 of the dose is exported in the form of unchanged urine. The semi -cancellation time in the plasma of cetirizin is approximately 10 hours. Cetirizin has linear dynamics at the dose of 5-60 mg.

The drug in breast milk, but almost does not go through the bloody barrier.

Before taking Ezinapc Ampharco medicine for allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

How to use

Ezinapc Ampharco is taken orally, or not with food.

Dosage

Dosage of Ezinapc Ampharco for adults and children aged 6 and older: Take 1 tablet of 10 mg x 1 time/ day.

Ezinapc ampharco dose for patients with liver failure: The dose should be half reduced.

Dosage Ezinapc Ampharco for patients with renal failure: The dose is adjusted according to the CLCR as the following table:

Kidney function

CLCR

(ml/minute)

Dosage

Normal

≥ 80

10 mg x 1 time/day

50-79

10 mg x 1 time/day

Moderate kidney failure

30-49

5 mg x 1 time/day

5 mg every 2 days

What to do when overdose?

Symptoms of ezinapc overdose are: Sleeping in adults, in children may be agitated.

Serious overdose should cause vomiting and gastric lavage along with supportive methods. Up to now, there is no specific antidote.

Hemorrhage is not effective in treating overdose of Cetirizin.

What to do when you forget 1 dose?

If you forget to use the drug, take that dose as soon as you remember. Ignore the forgotten dose if the time to remember is close to the next dose. Do not take additional pills in the next dose to compensate for the forgotten dose.

Side Effects

Common (ADR> 1/100)

The most common is the phenomenon of chicken sleep. The ratio of ADR depends on the dose.

In addition, the drug also causes fatigue, dry mouth, sore throat, dizziness, headache, nausea.

Less (1/1000

Anorexia or increased appetite, urinary retention, flushing, increasing salivation.

Rare (ADR

Hemorrhagic anemia, thrombocytopenia, severe hypotension, anaphylaxis, hepatitis, cholestasis, glomerulonephritis.

Warnings

Contraindicated

Contraindicated treatment with Ezinapc in the following cases:

People with a history of allergies to cetirizin, with hydroxyzin or any ingredients of the drug.

Precautions when using

Need to adjust the dose of Ezinapc in liver failure patients. For patients with galactose intolerance, lactase deficiency or glucose-glucose absorption should not be taken.

affects the ability to drive and operate machinery

In some patients using Cetirizin have a chicken sleep, so be cautious when driving, or operating machinery when using Cetirizin.

time pregnancy

Although Cetirizin does not cause teratogenicity in animals, there is no adequate studies on pregnant people, so do not use drugs during pregnancy.

period for breastfeeding

Cetirizin is excreted in milk, so avoid breastfeeding when the mother uses the medication.

Drug interaction

Concentration of this medication with alcohol or other central neurological inhibitors may increase the effects of these drugs.

Cetirizin clearance is slightly reduced when taken with 400mg Theophyllin.

Storage

The drug needs to be stored at temperatures below 30ºC, avoid direct light and wet place.

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