Fagendol 5mg HuteCs medicine for preventive treatment migraine (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Flunarizine

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

indications

Fagendol 5 mg drug is indicated in the following cases:

Preventive treatment for migraine.

Pharmacological

flunarizin prevents harmful effects due to calcium overload in the cell by reducing calcium flow through excessive membrane. Flunarizin does not prevent the normal lipstick stability of calcium in the cell. Flunarizin also has antihistamine activity.

The effect of flunarizin in migraine prevention is due to the ability to reduce the frequency of migraine. Flunarizin also reduces the level of migraine but with less level, and does not affect the time of migraine.

Pharmacokinetics

absorption

flunarizin is well absorbed after drinking, the peak concentration in plasma is achieved from 2 to 4 hours after drinking. When used at a dose of 10 daily, the plasma concentration increases gradually and the concentration in a stable state is from 39 - 115 ng/ml after 5-6 weeks of using the drug, depending on the individual.

Distribution

is widely distributed into tissues. The concentration of drugs in tissue, especially adipose tissue and bone tissue several times the drug concentration in plasma. The drug in the form of links accounts for 99.1%, of which plasma protein is about 90% and about 9% is distributed to blood cells, only nearly 1% exists in the form of free plasma.

Metabolism

is metabolized mainly by the aromatic hydrolysis reaction in the liver.

Elimination

Within 48 hours after taking the only dose, the excretion of flunarizin and its metabolites in urine is less than 0.2% and in the stool is less than 6%, this proves that the drug is eliminated very slowly after a long time. The sale time of the drug is about 19 days.

Before taking Fagendol 5mg HuteCs medicine for preventive treatment migraine (10 blisters x 10 tablets)

How to use

oral drugs used in the evening.

Dosage

Adults and children over 12 years old

The usual dose is 10 mg of flunarizin per day. Patients have some unwanted effects that can reduce the dose, maintain at 5 mg daily.

Older people

No dose reduction.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In this case, supporting therapies such as gastric lavage and if necessary, you can use activated carbon.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fagendol 5 mg, you may experience unwanted effects (ADR).

Nervous system: Because depression symptoms can occur, patients should be closely monitored. If these symptoms occur need to stop treatment.

Symptoms of foreign tapes: Symptoms such as convulsions, slow movement, face paralysis, restless sitting, trembling, trembling people may occur. Stop using drugs in these cases, if severe cases should use appropriate support therapy such as Parkinson's medication.

Liver: The liver function abnormalities such as increasing AST, ALT, ALP, LDH concentration may occur but rarely, so the patient should be closely monitored. If these abnormalities occur should stop treatment.

Hypersensitivity: Because the hypersensitivity reaction is as possible, it is possible to closely monitor the patient. If you see hypersensitive signs, you should stop taking the drug.

Digestive: dry mouth, stomach discomfort, constipation, nausea, anorexia and diarrhea can occur but rare.

Other side effects: Sometimes drowsiness occurs, fatigue. Weakness, discomfort, headache, dizziness, dizziness, insomnia, hot, weight gain, edema, urinary retention, milk secretion may occur but rare. (The phenomenon of lactation may occur in women using birth control pills).

Instructions on how to handle ADR

Notify the doctor any effect when taking the drug. If you need information, please ask the doctor.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Fagendol 5 mg is contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with a history of depression or patients who have foreign disorders.

Pregnant women.

Children under 12 years old.

Be cautious when using

Symptoms of foreign tower (e.g. slow movement, paralysis of the tower, standing still) or depression symptoms may occur when taking the drug. Because these symptoms may occur a few months after stopping the drug, it is necessary to mean the following issues:

Patients should be closely monitored during the treatment period to early detect foreign symptoms and depression symptoms. Stop treatment if necessary.

Because patients with a history of foreign symptoms may have some difficulties in this product, such as up and down stairs, changing clothes, so these patients need to be closely monitored.

Dosage response should be checked after 2 months from the beginning of the drug.

Response: The drug response needs to be checked regularly (for example 1 month) then decide whether to continue taking the drug or not.

Not responding: Should stop taking the drug.

Not determined: temporarily stop taking the drug. Depending on the severity of the decision, whether or not to use the drug.

Because the sedative effect and/or chicken sleep can occur in some patients during the time of using flunarizin, so it should not be operated on machinery or trains when taking the drug.

Be cautious when taking the drug for:

Patients with liver disease.

Elderly.

The ability to drive and operate machinery

The drug can cause dizziness, headache, drowsiness so be careful when used for drivers and machinery operation.

Pregnancy

Not for pregnant women.

The period of breastfeeding

There has been no research to determine the safety of women who are breastfeeding, so be cautious when used for breastfeeding women.

Medicinal interaction

Dosage should be adjusted in patients who use this medication simultaneously with medicine for high blood pressure. Flunarizin Hydrochlorid is a calcium channel blockers, so when used with drugs for hypertension in the calcium channel blocker, the plasma concentration of both flunarizin hydrochlorid and hypertension drugs for calcium channel blockers increases.

This is because both drugs are metabolized by the same liver enzyme, so it reduces the metabolism of each drug. Therefore, for patients who are using Flunarizin Hydrochlorid if they need to use hypertension medication, it is necessary to start at the lowest dose, then monitor the patient's blood pressure and gradually increase the dose of hypertension to the dose to meet the treatment.

For patients being treated with hypertension in the calcium channel blockers if they need to be treated with Flunarizin hydrochlorid, it should start with the dose of Flunarizin Hydrochlorid 5 mg/day and monitor the patient's blood pressure. The adjustment of the dose of flunarizin hydrochlorid or medication for hypertension must be based on the response of the patient in each specific case.

Be cautious when using Flunarizin at the same time with alcohol, sleeping pills, or painkillers, sedation because of the excessive sedative effect.

Storage

Storage in closed packaging, at temperatures below 30 ° C.

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