Falgankid medicine 250mg/10ml CPC1 Hanoi reduces fever pain in young children (4 blisters x 5 tubes)

Dosage form Oral solution
Specifications Box of 4 blisters x 5 tubes
Ingredient Paracetamol

Ingredient

Thành phần cho 10ml

Composition information	Content
Paracetamol	250mg

Uses

Indications

Falgankid 250 medicine is indicated in the following cases:

Antipator of children fever. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

Paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time.

pharmacokinetic

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage.

After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%), there is also a small amount of hydroxyl metabolism - chemical and reducing acetyl. Children are less likely to glucuro than drugs than adults.

paracetamol is n - hydroxylation by cytochrom P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus is dedicated. However, if you take high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver, in that situation, its reaction to the sulfhydryl group of the liver protein increases, which can lead to liver necrosis.

Before taking Falgankid medicine 250mg/10ml CPC1 Hanoi reduces fever pain in young children (4 blisters x 5 tubes)

How to use

oral drugs. Break the plastic tube and directly drink the solution in the tube. Can dilute with water, or drink water after taking the medicine.

Dosage

Children 2 - 4 years old

Take ½ tube/time, 3-4 times/day.

Children 4 - 11 years old

Take 1 tube/time, 3-4 times/day.

Children over 11 years old

Take 2 tubes/time, 3-4 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression

Paracetamol poisoning may be due to a single -dose, or a large dose of paracetamol (e.g. 7.5 - 10g per day, for 1-2 days), or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death. Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Methemoglobin - blood, leading to purple blue, mucous membranes and nails is a sign of acute poisoning P - Aminophenol, a small amount of sulthemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated, and delirium. Next can be inhibiting the central nervous system, stunned, lower body heat, tired, fast breathing, shallow, fast, weak, uneven, low blood pressure and circulatory failure. Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The deadly twitch may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of bilirubin in plasma can also increase, in addition, when the liver lesions spread, the long prothrombin time. It is possible that 10% of patients with untreated poisoning have serious liver damage, out of which 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. The liver biopsy detects the central necrosis of the lobe except the area around the door vein. In cases of non -death, liver lesions recover after weeks or months.

Treatment

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Gastric lavage is needed in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver.

n-acetylcysteine works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N - Acetylcystein includes skin rash (including day, no need to stop the drug), nausea, vomiting, diarrhea, and anaphylactic reaction.

If there is no N - acetylcystein, methionine can be used (see specialized methionine). Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Falgankid 250, you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs. In a few individual cases, Paracetamol has caused neutropenia, thrombocytopenia and all bloody hematoma.

Uncommon, 1/1000

DA: Ban.

stomach - intestines: nausea, vomiting. Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Falgankid 250 drug contraindicated in the following cases:

Patients with anemia many times or heart, lung, kidney or liver disease.

Personal hypersensitivity to paracetamol.

Patients with glucose deficiency - 6 - phosphate dehydro -agen.

Be cautious when using

Doctors need to warn patients about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

Ophthalmology, leukopenia and all bloody hemoglobin have occurred with the use of P - Aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Must use paracetamol carefully in patients with anemia before, because purple blue may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to pregnancy development. Therefore, Paracetamol should only be used in pregnant women when needed.

Breastfeeding period

Research in mothers using paracetamol after lactation, does not see unwanted effects in breastfed children.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion. This effect seems less or not clinically important, so paracetamol is more popular than salicylate when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin or indandion.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions. However, patients must restrict self -use of paracetamol while taking anti -convulsions or isoniazid.

Storage

Store in closed packaging, avoid light, temperature below 300C. Do not store at a small temperature of more than 80C (temperature)

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