Fefasdin 60 khapharco treatment of allergic rhinitis, indefininant urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Fexofenadin hydrochlorid
Indication Rhinitis, allergic rhinitis, itching, stuffy nose

Ingredient

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Composition information	Content
Fexofenadin hydrochlorid	60mg

Uses

Indications

Fefasdin 60 drug is indicated in the following cases:

Treatment of symptoms in seasonal allergic rhinitis, malefinity chronic urticaria in adults and children over 6 years old. The drug is an active metabolitus of terfenadin but no longer toxic to the heart due to not inhibiting potassium channels associated with myocardial cycles. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

Dynamic pharmacokinetics

absorption: Fexofenadin hydrochloride absorbs well when used orally and starts to work after drinking 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (until about 4 hours). The antihistamine effect lasts more than 12 hours.

Distribution: The ratio of linking to the drug's blood protein is 60-70%, mainly with albumin and alpha-acid glycoprotein. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism: Fexofenadin is very little metabolized (about 5%, mainly in the intestinal mucosa. Only about 0.5-1.5% are metabolized in the liver thanks to the cytochrom paso enzyme into active substance). About 3.5% of fexofenadin dose is metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives. This metabolite is only seen in the stool, so there may be the participation of intestinal bacteria into this metabolism.

Elimination: Half of the excretion of Fexofenadin is about 14.4 hours, longer (31-72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11-12%) in constant form.

Pharmacokinetics in people with renal failure:

CICR 41-80 ml/minute: The peak concentration is 87%high, half-life eliminated longer than 50%.

CLCR 11-40 ml/minute: peak concentration is more than 111%, half-life eliminated longer than 72%.

CLCR

Ineffective blood decomposition removal.

Before taking Fefasdin 60 khapharco treatment of allergic rhinitis, indefininant urticaria (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

The usual dose for adults and children over 12 years: 1 capsule 2 times/day.

Elderly and kidney failure:

Children aged 12 years and older and adults with kidney failure, the elderly: Start taking a dose of 1 tablet 1 time/day, adjust the dose according to the kidney function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Using conventional measures to remove the drug that has not been absorbed in the gastrointestinal tract. Support support and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fefasdin 60 you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neuroscope: Sleep, fatigue, headache, insomnia, dizziness.

Digestive: Nausea, indigestion.

Body: viral infection (colds, flu), dysmenorrhea, back pain

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares.

digestive: dry mouth, abdominal pain.

Rare, ADR

Immune: urticaria, itching, angioedema, chest tightness, shortness of breath, redness, anaphylaxis.

Instructions on how to handle ADR

The unwanted effects of the drug are usually mild, only 2.2% of patients have to stop the drug due to the unwanted effects of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Fefasdin 60 drug contraindicated in the following cases:

Hypersensitivity to fexofenadin, terfenadin or any ingredients of the drug.

Be cautious when using

Although the drug has no heart toxicity like Terfenadin, it still needs to be cautious for people who have a cardiovascular risk or have a long QT from before.

Do not use any other antihistamine drugs when using fexofenadin hydrochloride.

Caution and adjustment of appropriate dosage when taking drugs for people with impaired renal function, the elderly (over 65 years old).

Safety and effectiveness of drugs in children under 6 years old have not been determined.

Need to stop Fexofenadin at least 24 - 48 hours before conducting subcutaneous antigen tests.

The drug contains lactose excipients, not suitable for patients with lactase enzyme deficiency, malabsorption syndrome due to blood galactose.

The ability to drive and operate machinery

Although Fexofenadin hydrochloride is less likely to cause drowsiness, it still needs to be cautious when driving or controlling machinery requires alertness.

Pregnancy

There is no complete research document on pregnant women, so only Fexofenadin for pregnant women when the benefit of the mother is superior to the risk for the fetus.

The period of breastfeeding

It is not clear whether the drug is excreted through breast milk, so be careful when using fexofenadin for breastfeeding women.

Drug interaction

erythromycin and ketoconazole increases concentration and area under the concentration curve - time of fexofenadin hydrochloride in the blood.

Antacomicius containing aluminum, magnesi if used simultaneously with fexofenadin hydrochloride will reduce the absorption of the drug, so they must use these drugs about 2 hours apart.

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

less than 30 ° C. Dry place, avoid light.

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