Fegra 120 pymepharco medicine for seasonal allergic rhinitis, chronic spontaneous urticaria (1 blister x 10 tablets)

Dosage form Hard capsules
Specifications Box of 1 blister x 10 tablets
Ingredient Fexofenadin hydrochlorid

Ingredient

Composition information	Content
Fexofenadin hydrochlorid	120mg

Uses

indications

Fegra 120 drugs for adults and children over 6 years old in the treatment of allergic rhinitis: sneezing, runny nose, nasal congestion, itchy mouth, throat, redness, watery eyes, hives and chronic spontaneous urticaria.

Pharmacological

Fexofenadin is a second -generation antihistamine drug, which has a selective and specific antagonistic effect on peripheral receptors. The drug is a metabolic substance that has the activity of terfenadin, also competing with histamines at H1 receptors in the gastrointestinal tract, blood vessels and respiratory tract, but no toxicity for the heart due to not inhibiting potassium channels related to the extreme of myocardial cell. Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no effect on inhibiting receptors of Alpha or Beta - Adrenergic.

In the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into the H1 receptor to form a sustainable complex and slowly separated.

Dynamic pharmacokinetics

absorption: good absorption drug when used orally. After drinking, the peak concentration in the blood is achieved after 2-3 hours.

Distribution: The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha acid glycoprotein. The distribution volume is 5.4 - 5.8 liters/kg. Fexofenadin does not pass the brain barrier.

metabolism: approximately 5% of the dose of metabolic drugs. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

Elimination: 14.4 hours of sale, longer in renal failure people. The drug is excreted mainly in feces (approximately 80%), 11 - 12% of the dose is eliminated through urine in constant form.

Before taking Fegra 120 pymepharco medicine for seasonal allergic rhinitis, chronic spontaneous urticaria (1 blister x 10 tablets)

How to use

Fegra 120 drugs for oral.

Dosage

Allergic rhinitis:

Adults and children over 12 years: 60mg x 2 times/day or 180mg x 1 time/day.

Children from 6 to 12 years: 30mg x 2 times/day.

Adults and children over 12 years old: 60mg x 2 times/day.

Children from 6 to 12 years old: 30mg x 2 times/day.

Adults and children over 12 years old have kidney failure or hemolysis: 60mg x 1 time.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The unwanted effects of the drug are not affected by the dose, age, gender and race of the patient.

Common

Neuroscope: drowsiness, fatigue, headache, insomnia, dizziness.

Neurological: Fear, sleep disorders, nightmares.

Skin: Ban, urticaria, itching.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Fegra 120 drugs contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Be cautious when used

Although the drug has no heart toxicity like the mother of Terfenadin, it still needs to be careful to monitor when using fexofenadin for people who are at risk of cardiovascular disease or have a long -lasting QT range from before.

It is necessary to recommend that patients do not use any other antihistamine drugs while using fexofenadin.

Be careful and adjust the appropriate dose when taking drugs for people with impaired renal function because the concentration of drug in plasma increases due to half -life elimination. Be careful when taking medicine for tall people (over 65 years old) often has renal physiological impairment.

Safety and effectiveness of drugs in children under 6 years old have not yet been determined.

It is necessary to stop fexofenadin at least 24 - 48 hours before conducting antigen tests in the skin.

The effect of the drug on the ability to drive and operate machinery

Although Fexofenadin is less drowsy, it is necessary to be cautious when driving or controlling machinery requires alertness.

Use drugs for women during pregnancy and lactation

Pregnancy: Because they have not fully studied in pregnant women, they only use fexofenadin for pregnant women when the benefit of the mother is better than the risk for the fetus.

Demonstrate period: It is not clear whether the drug is excreted through breast milk, so it is necessary to be cautious when using fexofenadin for breastfeeding women.

Drug interaction

Fexofenadin is very little metabolized through the liver, so it is less interactive with the medications metabolized through the liver. Using fexofenadin with erythromycin or ketoconazole increases fexofenadin levels in plasma 2-3 times. However, this increase does not affect the QT interval, and compares with the above drugs when used individually, nor an additional side effect.

Antacomic antacids containing aluminum, magnesi if used simultaneously with fexofenadin will reduce the absorption of the drug, so using these drugs apart (about 2 hours).

Storage

In a dry, cool place (below 30 ° C), avoid light.

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