Feliccare medications longevity and treatment for anemia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Ferrous fumarate, folic acid, cyanocobalamin

Ingredient

Composition information	Content
Ferrous Fumarate	162mg
Folic acid	0.75mg
Cyanocobalamin	7.5mcg

Uses

Indications

Feliccare drugs are indicated in cases of prevention and treatment of general anemia due to iron deficiency, folic acid deficiency, especially pregnant women, breastfeeding, malnutrition children, malnutrition, patients after surgery, blood for blood, weakness ...

Pharmacokological

iron Fumarat:

Iron is a trace element necessary for the body. Iron is essential for creating hemoglobin, myoglobin and cytochrome respiratory enzyme C. The introduction of folic acid is added to Fumarat iron to use for pregnant people to prevent huge red blood cell anemia. Combining folic acid with iron has a good effect on anemia during pregnancy than when using a single substance.

Folic acid:

Folic acid is a vitamin of Group B, in the body, it is reduced to tetrahydrofolate, which is the coenzyme of many metabolic processes including synthesis of nucleotides with Purin or Pyrimidine nuclei; Therefore, it affects DNA synthesis. When vitamin C, folic acid is converted into leucovorin, which is essential for DNA and RNA synthesis. Folic acid is an indispensable factor for nucleoprotein synthesis and normal red blood cells; Folic acid deficiency causes huge red blood cell anemia like anemia due to vitamin B12 deficiency. Folic acid also participates in some amino acid changes, in format formation and use.

cyanocobalamin (vitamin B12):

In the human body, Cyanocobalamin forms active coenzymes, methylcobalamin and 5 - deoxyadenosylcobalamin is essential for copying and growth cells. Methylcobalamin is needed to create methionine and conduct as S-Adenosylmethionin from Homocystein. In addition, when vitamin B12 levels are not sufficient, it will cause impaired function of some other types of folic acid in the cell.

Hematology abnormalities in people with vitamin B12 deficiency are due to this process. 5 - Deoxyadenosylcobalamin is needed for isomer, convert l - methylmalonyl coa into success. Vitamin B12 is essential for all tissues with strong cell growth such as hematoma, small intestine, and uterus. Vitamin B12 deficiency also causes neuron cancellation.

pharmacokinetics

iron fumarat:

iron is absorbed through food, the most effective from iron in meat. Normally iron is absorbed in the duodenum and head close to the colon. A normal person does not lack iron, absorbs about 0.5 - 1mg of elemental iron daily. Iron absorption increases when low iron reserves or increased iron demand. The whole iron absorption increases to 1 - 2mg/day in normal menstrual periods and can increase to 3 - 4mg/day in pregnant women. Young children and teenagers also have increased iron demand in the period of strong development.

iron absorption is reduced when there are chelate substances or complex agents in the intestine and increase when there is hydrochloric and vitamin. Therefore, sometimes iron is used in combination with vitamin C.

Iron is stored in the body in two forms: ferritin and hemosiderin.

About 90% of iron inserted into the body is discharged.

iron absorption depends on the amount of iron reserves, especially ferritin, in the intestinal mucosa and on the body's red blood cell speed.

Folic acid:

Fast -released antidote in the stomach and absorb mainly at the beginning of the small intestine. Folic acid in normal diet is absorbed very quickly and distributed in tissues in the body. The drug is stored mainly in the liver and is actively focused in cerebrospinal fluid. Every day about 4 - 5 micrograms eliminate through urine, drink high -dose folic acid, causing the amount of vitamins to eliminate through the urine in proportion. Folic acid passes through the placenta and is in breast milk.

cyanocobalamin (vitamin B12):

After drinking, vitamin B12 is absorbed through the intestine, mainly in ileum in two mechanisms: the passive mechanism when the amount is high; And the active mechanism, allowing the absorption of physiological doses, but it is necessary to have the intrinsic factor, glycoprotein, which is secreted by the cells into the stomach mucosa. The level of absorption is about 1% does not depend on the dose and therefore 1mg daily will satisfy the daily needs and sufficient to treat all types of vitamin B12 deficiency.

After intramuscular injection, the peak concentration in plasma is achieved after 1 hour. After absorption, Vitamin B12 is linked to Transcobalamin II and is quickly removed from plasma to distribute priority to the liver parenchyma. The liver is the vitamin B12 reserve for other tissues. About 3 micrograms of cobalamin excreted daily bile, of which 50 - 60% are the derivatives of cobalamin that cannot be reabsorbed. Hydroxocobalamin is better absorbed through the gastrointestinal tract, and is affectionate with larger tissues than cyanocobalamin.

Before taking Feliccare medications longevity and treatment for anemia (10 blisters x 10 tablets)

How to use

Take oral use.

Avoid drinking at the same time with tea because tannin tea creates complexes with iron ions that reduce the effect of the drug.

Do not drink when lying.

Dosage

Adults: 2 - 4 capsules/day.

Children: 1 - 2 capsules/day.

Pregnant women: 1 tablet/day, from pregnancy.

Treatment time depends on the cause and iron deficiency, but the treatment time with oral iron takes about 4-6 months to recover anemia due to iron deficiency.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

iron fumarat:

Most iron preparations are toxic, iron salts are dangerous for children. Toxic doses: less than 30 mg Fe2+/kg may be toxic to average and over 60 mg of Fe2+/kg seriously toxic. The dose of death may be from 80 - 250 mg Fe2+/kg. There has been informed of some cases of deadly poisoning in children 1-3 years old. The lowest dosage for children is notified of 650 mg Fe2+.

Symptoms: abdominal pain, nausea, vomiting, diarrhea accompanied by blood, dehydrated, acidic and shock with chicken sleep. At this time, there may be a period that seemed to have recovered, no symptoms, but after about 6-24 hours, the symptoms reappeared again with blood clotting and cardiovascular disease (heart failure due to myocardial lesions). Some manifestations such as high fever, hypoglycemia, liver poisoning, kidney failure, seizures and coma. Easy to have a risk of intestinal perforation if taken high doses. In the recovery stage, there may be cirrhosis, pyloric stenosis. It may also be infected by Yersinia Enterocolica.

Treatment: First, gastric lavage immediately with milk (or carbonate solution). If possible, iron quantifies in serum. After washing the stomach, pump Deferoxamine solution (5 -10 g deferoxamine dissolved in 50- 100 ml of water) into the stomach through the catheter. In the case of iron used over 60 mg/kg body weight, or when there is severe symptoms, the first must give intravenous defaoxamin. Intravenous injection dose of 15 mg/kg/hour until symptoms are gone and until Fe2+ concentration decreases below 60 micromol/liter. It is necessary to use higher doses. If you need to raise blood pressure, dopamine should be used. Division if there is kidney failure. Adjust the balance of base acid and electrolytes, and rehydration.

Vitamin B12: There is no overdose.

Folic acid: No overdose information.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Feliccare, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: The reaction of stomach irritation, abdominal pain with nausea and vomiting, diarrhea or constipation, may appear dark stools. These side effects may be reduced by taking medication during or after meals or starting the drug at low doses and then increasing the dose gradually.

Teeth: Can teeth change temporary color.

Uncommon, 1/1000

No information.

Rare, 1/10000

Body: Anaphylaxis, fever.

External skin: Fish egg -shaped reaction, urticaria, itching, red skin, rash. digestive: There may be digestive disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Feliccare drugs contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Diseases iron infection.

Stomach ulcers, each area of guts and gastric ulcer. iron excess body: iron tissue disease, hemosi - derine and hemolytic anemia.

Esophageal and bag stenosis and digestive tract.

Not used for children under 12 years old and the elderly.

Not used for anemia for unknown cause.

Malignant: Because vitamin B12 increases the tissue with high growth rate, there is a risk of progression.

Patients with allergies (asthma, eczema).

Caution when using

Do not use iron to treat hemolytic anemia unless the case of iron deficiency.

Do not use treatment for more than six months without the monitoring of the physician.

Do not use iron injected in combination with oral form to avoid excess iron.

Do not use medication for patients who are regularly transferred because in hemoglobin of red blood cells contains a significant amount of iron.

Be careful for patients with tumors dependent folat.

Be cautious when used for patients with suspected stomach ulcers, anise inflammation or chronic intestinal ulcer.

Do not take medicine when lying.

The ability to drive and operate machinery

The drug does not cause drowsiness, so it can be used for drivers and operating machinery.

Pregnancy

is used to supplement iron and folic acid for pregnant women.

Breastfeeding period

There is no problem that occurs when taking vitamin B12 with daily recommended dose in pregnant and lactating women.

Drug interaction

Avoid using iron combination with some quinolones such as ofloxacin, ciprofloxacin, norfloxacin.

Simultaneously used with antacids such as carbonate calcium, sodium carbonate, magnesium trisilicate or tea water reduces the absorption of iron.

Simultaneous use of iron and tetracyclin is reduced.

Concentrated with chloramphenicol absorbs iron salts slowly.

iron salt reduces the absorption of penicilamin, carbidopa, levodopa, methyldopa.

Folic acid and sulphasalazin: absorbing folat may be reduced.

Folic acid and oral contraceptive: Oral contraceptives reduce metabolism of folat and cause folat and vitamin B12 to a certain extent.

Folic acid and anti -convulsions: If using folic acid to supplement folat may be caused by anti -convulsions, the concentration of anti -convulsions in serum may be reduced.

Folic acid and cotrimoxazol: cotrimoxazole reduces the treatment of huge red blood cell anemia of folic acid.

Absorption of vitamin B12 from the gastrointestinal tract may be reduced when used with Neomycin, aminosalicylic acid, anti -receptor drugs H2 and Colchicin.

Serum concentration of vitamin B12 may be reduced when used simultaneously with oral contraceptives. Chloramphenicol used on the gastrointestinal tract may reduce the effect of vitamin B12 in anemia.

The treatment effect of vitamin B12 may be reduced when used simultaneously with omeprazol. Omeprazol reduces gastric acid, so it reduces the absorption of vitamin B12.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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