Felodipine Stella 5mg Retard controls hypertension (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Felodipine

Ingredient

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Composition information	Content
Felodipine	5mg

Uses

indications

Felodipine Stella 5mg drug is indicated for treatment in the following cases:

Control hypertension. Due to high selection on artery smooth muscles, felodipine at the dose of treatment does not have a direct impact on the contraction or transmission of the heart muscle.

The drug can be used individually or in combination with other hypotension drugs, such as beta blockers, diuretics or ACE -inhibitors inhibitors to increase lowering blood pressure effects. Felodipine reduces both systolic and diastolic blood pressure and can be used in the case of individually systolic hypertension.

Due to the no effect on venous muscles or sympathetic vascular control system, Felodipine does not cause hypotension.

Felodipine has anti -anemia effects and anti -angina due to improving the supply/oxygen balance for the heart muscle. Felodipine can be used individually or in combination with beta blockers in stable angina patients.

Hemodynamic effects: The effect of felodipine depends on doses, in patients with mild to medium hypertension, hypotension effects often reach about 2 hours after taking the first dose and lasting at least 24 hours with the ratio of the bottom/peak is more than 50%.

The impact on the kidneys: Felodipine has the effect of sodium and diuretic. Felodipine has no effect on daily potassium elimination, in patients with renal function, glomerular filtration speed may increase.

pharmacokinetics

absorption and distribution

Felodipine is completely absorbed by oral in the form of prolonged release. Birth of the body of Felodipine is approximately 15% and does not depend on the dose within the treatment dose. With controlled release, long absorption phase.

This effect helps felodipine levels in plasma remain in the limit of treatment within 24 hours. Felodipine is connected to plasma proteins (mainly with albumin) about 99%.

Metabolism and elimination

Felodipine's waste sale time in the last phase is 25 hours. There is no accumulation during treatment. Felodipine is metabolized by the liver into an inactive metabolic substance, in older patients and patients with impaired liver function, the average concentration in Felodipine plasma is higher than young people. About 70% of the dosage of drugs are eliminated in the form of metabolites in the urine; The rest is eliminated through feces. Under 0.5% of the dose is found in the form of unchanged.

Felodipine's

pharmacokinetics does not change in patients with impaired renal function.

Before taking Felodipine Stella 5mg Retard controls hypertension (10 blisters x 10 tablets)

How to use

Felodipine Stella 5mg is used by oral.

The drug should be swallowed with water, not chewed or crushed; Just take medicine when hungry. Drink before breakfast at least 30 minutes.

Dosage

Hypertension control:

The starting dose in adults is 5 ng/day to drink 1 time. The dose should be adjusted according to the blood pressure response and the use of the patient's drugs, usually the adjustments are more than 2 weeks apart. Depending on the response of the patient, the dose may be reduced to 2.5 mg/day or the dose increased to 10 ng/day. If necessary, an additional anti -hypertension drug is used as beta blockers.

Maintenance dose:

2.5 - 10 mg/day, drink 1 time in the morning.

Stable prophylaxis:

Should start at a dose of 5 mg orally once and then if it is necessary to increase the dose to 10 mg/day.

Children:

Do not use felodipine for children because of safety and effectiveness that has not been proven

Patients with liver failure, kidney failure and elderly patients:

Initially used dose is 2.5 mg per day, the adjustment of the dose should be conducted carefully and closely investigate the patient's blood pressure. In clinical trials, there has been an increased risk of peripheral coating in elderly patients using Felodipine doses in excess of 10 mg daily.

What do

do when overdose?

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Felodipine Stella 5mg you may experience some unwanted effects (ADR).

Common: dizziness, flushing, headache, hypotension, peripheral edema, fast heart, brushing chest.

vomiting and other digestive disorders, urination, coma, eye pain, visual disorders and mental weakness also occur.

Increasing chest pain caused by ischemia can also occur at the beginning of treatment and in some patients with excessive hypotension leading to brain or heart anemia or temporary blindness.

Other side effects: rash (including many types of erythema), fever, liver function abnormalities such as bile stasis due to hypersensitivity reactions, gums hyperplasia, muscle pain, shudder and impotence.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Felodipine Stella 5mg contraindications in the following cases:

Hypersensitivity to Felodipine or any ingredients of the drug. heart.

Be cautious when taking the drug

Be careful when taking Felodipine for the following cases:

Patients with low heart reserves, heart failure. The set after using Felodipine.

The ability to drive and operate machinery

There is no report.

During pregnancy and lactation

pregnancy

Do not use felodipine during pregnancy.

Breastfeeding period

Due to serious side effects in breastfeeding children, it is necessary to decide or stop breastfeeding or stop using the drug, after considering the importance of the drug to the mother.

Drug interaction

CYP3A4 inhibitors

Felodipine is metabolized by CYP3A4. The combination of CYP3A4 inhibitors (ketoconazole, otraconazole, erythromycin, cimetidin) with felodipine increases the level of felodipine in plasma several times, leading to increased effects (lower blood pressure and increased heart rate).

digoxin

When combined with felodipine, there is no change in pharmacokinetics of digoxin in patients with heart failure.

anti -epileptic drugs

Felodipine's peaked plasma concentrations are significantly reduced in epilepsy patients using anti -epileptic drugs for a long time (phenytoin, carbamazepine or phenobarbital) than healthy volunteers. Should consider carefully when choosing hypertension treatment for these patients.

tacrolimus

Felodipine increases the concentration of Tacrolimus in the blood.

Interaction with food

When taking the drug along with a diet rich in fat or carbohydrate, the peak of the plasma of the drug increases by approximately 60%. The bioavailability of the drug also increased by approximately 2 times when used with grapefruit juice.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist.

Keep pills out of reach of children and pets.

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