Fenofibrate 200mg Domesco medicine for lipoprotein disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Fenofibrate

Ingredient

Composition information	Content
Fenofibrate	200mg

Uses

indications

Fenofibrate drugs are indicated in the following cases:

Treatment of blood lipoprotein disorders of IIA, IIB, III, IV and V Types, in combination with diet.

Pharmacokology

fenofibrate, derivative of fibric acid, is a blood lipid that inhibits cholesterol biosynthesis in the liver, reduces the components that cause atherosclerotic (very low density lipoprotein VLDL and lipoprotein LDL low density) increases the production of high -ratio lipoprotein lipoprotein (HDL) and reduces the blood trigly. Therefore, significantly improving cholesterol distribution in plasma.

Fenofibrate is used to treat hyperplote lipoprotein, IIA, IIB, III, IV and V along with a very limited diet of lipids.

Fenofibrate can reduce 20–25% of total cholesterol and 40–50% triglycerides in the blood. Fenofibrate treatment should be continuous.

Dynamic pharmacokinetics

absorption: Fenofibrate absorbed right in the digestive tract along with food. Absorption is greatly reduced if taken after fasting overnight. Peak concentration in plasma appears about 5 hours after taking the drug.

Distribution: No report.

Metabolism: quickly hydrolyzed into fenofibric acid activity. This substance is highly attached to plasma albumin and can push vitamin K anti -vitamin drugs from the mounting position.

Elimination: In people with normal renal function, the half -life of plasma is about 20 hours but this time increases a lot in kidney disease and fenofibric acid accumulated significantly in people with kidney failure daily. Fenofibric acid eliminated mainly in urine (70% within 24 hours, 88% within 6 days), mainly in the form of glucuronic complex, in addition to fenofibric acid in the form of reducing and its glucuronic complex.

Before taking Fenofibrate 200mg Domesco medicine for lipoprotein disorders (3 blisters x 10 tablets)

How to use

oral medication. Take medicine with meals. When treating fenofibrate, it is necessary to combine with lipid restrictions.

Dosage

Adults: The initial dose is usually 200 mg/day. If the whole blood cholesterol is still higher than 4 g/l, the dose can be increased to 300 mg/day. It is necessary to maintain the initial dose until blood cholesterol returns to normal, then mitigate daily dose. Must check blood cholesterol every 3 months, if blood lipid parameters increase, the dose must be increased to 300 mg/day.

Children over 10 years of age: It is necessary to determine the exact cause of hyperlipidemia in children. It is possible to combine with a strictly controlled diet within 3 months. The maximum dosage is 5 mg/kg/day. In some special cases, high doses can be used but must be designated by a specialist.

If the blood lipid concentration does not decrease much after 3–6 months of fenofibrate treatment, it is necessary to change therapy.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no specific antidote. If the overdose is suspected, symptomatic treatment should be treated and taken supportive measures when needed. Fenofibrate is not excluded when dialysis.

What to do when you forget a dose?

If you forget to take a dose, drink as soon as you remember. If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using fenofibrate drugs, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: digestive disorders, epigastric area, nausea, bloating, mild diarrhea.

No report.

Rare, ADR

Liver: Gallery of bile ducts.

Temporarily suspend medication.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Fenofibrate drugs are contraindicated in the following cases:

Severe renal failure.

Severe liver dysfunction.

Caution when using

must explore the liver and kidney function of the patient before using fibrate.

It is necessary to reduce the dose of anticoagulants to only one third of the old dose when starting to use fibrate and adjust if necessary. Regular monitoring of blood prothrombin. Adjust the anticoagulant dose during use and after stopping Fibrate 8 days.

Armor can be a factor that increases the likelihood of side effects.

Need to measure transaminase every 3 months, in the first 12 months of taking the drug.

Must suspend the drug if sgpt (ALT)> 100 international units.

File complications occur in patients with cholecystic cirrhosis or gallstones.

Do not combine fenofibrate with drugs that have a toxic effect on the liver.

If after 3–6 months of taking the drug and the amount of lipid in the blood changes is not significant, it is necessary to consider other therapy.

The ability to drive and operate machinery

The drug does not affect the ability to drive, operate machinery, work on high and other cases.

Pregnancy

should not be used for pregnant women.

Breastfeeding period

Do not take the drug in breastfeeding women.

Drug interaction

Fibrate combination with HMG-CoA Reductase inhibitors (Pravastatin, Simvastatin, Fluvastatin) will significantly increase the risk of muscle damage and acute pancreatitis.

Fibrate combination with cyclosporin increases the risk of muscle damage.

Fenofibrate increases the effects of anticoagulants, leading to an increased risk of bleeding due to pushing these drugs from a location associated with plasma proteins. Prothrombin should be monitored more often and adjust the anticoagulant dosage during fenofibrate treatment and after 8 days of stopping the drug.

Do not combine fenofibrate with liver poison (Monoamine inhibitors Oxidase, Perhexiline Maleate ...).

Storage

Store in a dry place, temperatures below 30ºC, avoid light.

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