Feparac USP medicine relieves pain and anti -inflammatory (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Paracetamol, ibuprofen

Ingredient

Composition informationContent
Paracetamol325mg
Ibuprofen400mg

Uses

indications

Feparac 325/400 USP drugs are indicated in the following cases:

  • Treatment of pain and inflammation in cases of muscle pain, bones, arthritis, arthritis, back pain, rheumatism and sports injury.
  • Pain relief and inflammation in dentistry, after obstetric and orthopedic procedures. Reduce other pain such as headaches, toothache, menstruation.

    • Pharmacology

    ibuprofen

    ibuprofen is an NSAID that has proved its effectiveness in inflammatory models by inhibiting Prostaglandin synthesis. Prostaglandin senses nerve ends that direction the mind with intermediate substances like Bradykinin. Therefore, ibuprofen produces analgesic effect through the peripheral inhibition of isenzyme cycloxygenase-2 (COX-2), then reduces the sensitivity of the sensitive nerve ends.

    ibuprofen has also been shown to inhibit the movement of white blood cells into inflamed areas.

    ibuprofen has a clear effect in the spinal cord due to COX inhibition. The antipyretic effect of ibuprofen is created by the central inhibition of prostaglandin in the hypothalamus. Ibuprofen inhibited the restoration of platelets.

    paracetamol

    Paracetamol's exact operation mechanism has not been completely defined.

    Different biochemical studies indicate the inhibition of the activity of the central COX-2.

    Paracetamol can also stimulate the activity of the 5-hydroxyryptamine road (serotonin) gradually decreasing, inhibiting the transmission of sensory signals in the spinal cord. Evidence shows that paracetamol is a very weak inhibitor of COX-1 and 2 peripheral isenzymes.

    Combining both paracetamol and ibuprofen

    This product is especially suitable for pain that requires stronger analgesic than ibuprofen 400 mg or paracetamol 1000 mg alone and faster pain relief than ibuprofen.

    pharmacokinetics

    ibuprofen

    ibuprofen is well absorbed through the gastrointestinal tract and widely linked to plasma proteins. Ibuprofen diffuses into joint fluid. When this product is used with food, the concentration of ibuprofen in plasma is lower and slower than an average of 25 minutes, but the overall absorption level is equivalent.

    ibuprofen is metabolized in the liver into two main metabolites with the main excretion through the kidneys, in the same form or in the main form of the main conjugate, along with an insignificant amount of ibuprofen. The excretion process of the kidneys happens quickly and fully. Selling time is about 2 hours.

    In limited studies, ibuprofen appears in breast milk with very low concentrations.

    paracetamol

    Paracetamol is easily absorbed through the gastrointestinal tract. Linking with plasma proteins is negligible at conventional treatment concentrations. When this product is used with food, the paracetamol peak concentration in plasma is lower and slower than an average of 55 minutes, but the overall absorption level is equivalent.

    Paracetamol is metabolized in the liver and excreted in urine mainly in the form of glucuronid and sulfate, with about 10% in the form of glutathione complex. Under 5% excreted in the form of paracetamol does not change. The sale time is about 3 hours.

    A small metabolic hydroxylation, usually created in a very small amount by the mixed oxidants in the liver and is detoxified by combining with glutathione in the liver, accumulating after overdose of paracetamol and liver damage.

    Combining both paracetamol and ibuprofen

    Bioarization and pharmacokinetics of ibuprofen and paracetamol are used as this product is not changed when used in combination in the form of a single dose or repeated dose. This product is manufactured by releasing technology simultaneously both ibuprofen and paracetamol, so that the active ingredients will bring about combination efficiency.

    Before taking Feparac USP medicine relieves pain and anti -inflammatory (10 blisters x 10 tablets)

    How to use

    Feparac medicine takes oral tablets after every meal.

    Dosage

    Dosage and duration of use for each specific case as prescribed by the treating doctor. The usual dose is as follows:

    Adults: 1 tablet every 4-6 hours. The maximum dose must not exceed 8 tablets/day.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    usually treat symptoms and support. If you have overdose, you need to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach.

    Because the drug contains paracetamol, N-acetylcysteine ​​can be used as a specific antidote as a specific antidote.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using Feparac 325/400 USP, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Digestive: stomach ulcers, hepatitis.

    • rare

  • Dizziness, anxiety, irritation, congestive heart failure, kidney failure, cystitis, polyur, atopic dermatitis, diverse roses of Stevens-Johnson syndrome, anemia.

    • Risk of cardiovascular thrombosis.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Feparac 325/400 USP drug is contraindicated in the following cases:

  • Hypersensitivity to any ingredients of the drug.

    • Patients with anemia many times or heart, lung, kidney or liver disease.

  • Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

    • Progressive peptic ulcer.

    hypersensitivity to aspirin or other nonsteroidal anti -inflammatory drugs (asthma, rhinitis, urticaria after taking aspirin).

  • Patients are being treated with anticoagulants.
  • Patients with congestive heart failure, decreased volume of circulatory amounts due to diuretic or kidney failure.
  • The last 3 months of pregnancy.

    • Be cautious when using

    ibuprofen

    ibuprofen should be used carefully in patients with stomach ulcers, liver disease, renal function, lack of internal blood clotting substances, elderly people, visual disorders, prolonging bleeding time.

    paracetamol

    Must use paracetamol carefully in patients with anemia before, because purple blue may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

    Drinking plenty of alcohol can cause toxicity to the liver of paracetamol; Should avoid or limit drinking.

    Special warning:

    Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

    Because the product contains ibuprofen, it is necessary to be cautious with the risk of cardiovascular thrombosis:

  • Non -steroid anti -inflammatory drugs (NSAIDs), not aspirin, using systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death.

    • Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

    To minimize the risk of adverse events, Feparac is needed at the lowest daily doses to be effective in the shortest possible time.

    The ability to drive and operate machinery

    There has been no report on the effect of drugs when used for drivers and operating machinery.

    Pregnancy

    Although the tested tests in humans have not been conducted, it is also found that paracetamol is absorbed through the placenta.

    Anti -inflammatory drugs can inhibit uterine contractions and slow delivery. Non -steroid anti -inflammatory drugs can also cause severe lung pressure and severe respiratory failure in newborns due to early closing of the ductus artery in the uterus. Anti -inflammatory drugs also inhibit platelet function, increasing the risk of bleeding.

    After taking nonsteroidal anti -inflammatory drugs, there is also a risk of less amniotic fluid and anuria in babies. In the last 3 months of pregnancy, it is very limited to use for any anti -inflammatory drugs. These drugs also have absolute contraindications in a few days before birth.

    The period of breastfeeding

    Related issues due to the use of paracetamol in humans during breastfeeding have not been recorded. Ibuprofen does not absorb breast milk.

    Drug interaction

    Alcohol: The risk of liver poisoning with paracetamol and ibuprofen may increase.

    anticoagulant, cooumarin or indandion derivatives: used for extension at the same time paracetamol and ibuprofen with these drugs can cause anticoagulant effects.

    High blood pressure: Ibuprofen prolongs the effect of many drugs that treat high blood pressure may be due to prostaglandin inhibition.

    Diuretics: Ibuprofen can reduce diuretic effects, increase sodium secretion, and reduce the effect of lowering blood pressure of diuretics, which can be due to prostaglandin inhibitors.

    digoxin: ibuprofen causes increased blood digoxin levels, need to adjust the dosgoxin dosage during and after the medication period.

    insulin and other oral diabetes treatment drugs: Ibuprofen may increase the hypoglycemic effect of these drugs, so the dose should be adjusted.

    ibuprofen When used simultaneously with lithium, methotrexate, probenecid may increase the risk of kidney toxicity.

    ibuprofen increases the unwanted effects of quinolon antibiotics on the central nervous system and can lead to seizures.

    ibuprofen when used simultaneously with other nonsteroidal anti -inflammatory drugs: increased the risk of bleeding and ulcers.

    Storage

    Store drugs in a dry place, avoid light, temperatures below 30 ° C.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    count views

    Popular Keywords