Fexofenaderm medicine 180mg Hasan treats allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Fexofenadin hydrochlorid
Indication Rhinitis, allergic rhinitis, sinusitis, contact dermatitis, sneezing, stuffy nose

Ingredient

Composition information	Content
Fexofenadin hydrochlorid	180mg

Uses

Indications

Fexofenaderm medicine is indicated in the following cases:

Treatment of seasonal allergic rhinitis, malefinity chronic urticaria in adults and children over 12 years old.

The drug is a metabolic substance that is active of terfenadin but no longer toxic to the heart due to no inhibition of potassium channels associated with myocardial cytoplasmic pole.

Fexofenadin has no significant effect on acetylcholin, dopamine antagonism and has no effect on inhibiting receptors of Alpha 1 or beta - adrenergic. At the treatment dose, the drug does not cause sleep or affects the central nervous system.

The drug has a fast and prolonged effect due to the slow -attached drug into the H1 receptor, forming a sustainable complex and separating slowly.

pharmacokinetic

absorption

Fexofenadin hydrochloride quickly absorbed with an average time to reach the peak concentration in plasma is 2-3 hours after drinking. Peak concentration in plasma is about 427ng/ml after taking single dose 120mg/day.

Distribution

The ratio of cohesion to the plasma protein of the drug is 60-70%, mainly with albumin and alpha 1-acid glycoprotein. The distribution volume is 5.4 - 5.8 liters/kg. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism

approximately 5% of the dose of the drug is metabolized. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

Elimination

FEXOFENADIN's semi -exhaust time is about 14.4 hours, longer in renal failure people. The drug excreted mainly in feces (approximately 80%), 11 - 12% of the dosage is eliminated through urine in constant form.

Before taking Fexofenaderm medicine 180mg Hasan treats allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

How to use

Oral drugs, time to take the drug regardless of the meal.

Dosage

Dosage for adults and children over 12 years old is 120mg fexofenadin hydrochloride/time/day (1 tablet/time/day).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling

Use conventional measures to eliminate unprocessed drugs in the gastrointestinal tract. Support support and symptomatic treatment. Hematoparoology does not significantly reduce the concentration of drugs in the blood (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fexofenaderm medicine, you may experience unwanted effects (ADR).

The unwanted effects of the drug are not affected by the dose, age, gender and race of the patient.

Common

Sleep, fatigue, headache, insomnia, dizziness, nausea, indigestion, viral infections (colds, flu), dysmenorrhea, respiratory infections, sore throat, cough, otitis media, sinusitis, back pain.

Fear, sleep disorders, nightmares, dry mouth, abdominal pain.

Rare

Ban, urticaria, itching, hypersensitivity reaction, angioedema, chest tightness, shortness of breath, redness, anaphylaxis.

Instructions on how

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Fexofenaderm drug is contraindicated in the following cases:

History of allergies to fexofenadin or any ingredients of the drug.

Precautions when using

Caution should be monitored when using fexofenadin for people at risk of cardiovascular or have about q - t in advance.

Do not use any other antihistamines when using fexofenadin.

Precautions and appropriate dose adjustments when taking drugs for people with renal function decrease because the drug concentration in plasma increases due to prolonged semi -emissions time. Adults and children over 12 years old with kidney failure or blood decomposition recommend the dose of 60mg fexofenadin hydrochloride x 1 time/day.

Be careful when taking medicine for the elderly (over 65 years old) often impaired renal physiology.

Hepatic failure: No dose adjustment.

Children from 6 to 12 years old: Recommendation to use pharmaceuticals containing fexofenadin hydrochloride at lower content of the content of Fexofenaderm film tablets 120 mg: 30 mg Fexofenadin hydrochloride X 2 times/day.

Children under 6 years of age: The safety and effectiveness of drugs in children under 6 years old have not been determined. Therefore, do not use fexofenadin in children under 6 years old.

Need to stop Fexofenadin at least 24 - 48 hours before conducting antigen tests on the skin.

The ability to drive and operate machinery

Although Fexofenadin is less likely to be drowsiness, it still needs to be cautious when driving or driving machines.

Pregnancy

Because there is no adequate study, only fexofenadin for pregnant women when the maternal benefits are superior to fetal risks.

Breastfeeding period

It is not clear whether the drug is excreted in milk or not, so be careful when using fexofenadin for breastfeeding women.

Drug interaction

Fexofenadin is only metabolized limited in the liver, so it does not interact with other drugs through the liver mechanism.

erythromycin and ketoconazole increase plasma and AUC concentrations of fexofenadin, the mechanism may be due to increased absorption and reduction of this drug. However, interaction is not clinically significant.

Aluminum -containing antacids, Magnesi Hydroxyd, if used simultaneously with fexofenadin, will reduce the bioavailability of fexofenadin, so they must use these drugs about 2 hours apart.

Fruit juice, including grapefruit juice, can reduce the bioavailability of fexofenadin, so avoid combining use.

Storage

Where dry, less than 300C.

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