Fexofenadin 120-HV USP medicine treats allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Fexofenadina
Indication Allergic rhinitis, eczema, itching, atopic dermatitis, contact dermatitis

Ingredient

Thành phần cho 1 viên

Composition informationContent
Fexofenadina120mg

Uses

indications

Fexofenadin 120 drug is indicated in the following cases:

  • Again the symptoms accompanied by seasonal allergic rhinitis such as sneezing, runny nose, itchy nose, stuffy nose, itchy/pharyngeal/throat.
  • Treatment of symptoms of

    urticaria.

    • Pharmacology

    Fexofenadin is a second -generation antihistamine drug, with specific antagonistic and selective effects on peripheral H1 receptors. The drug is a metabolic substance that is active of terfenadin but no longer toxic to the heart due to not inhibiting potassium channels associated with myocardial cytoplasm.

    Fexofenadin does not have a significant effect on acetylcholin antagonism, dopamine antagonistic and no effect in inhibiting receptor alpha or beta - adrenergic. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

    pharmacokinetics

    Good absorption drug when used oral. After taking a 60mg tablet, the peak concentration in the blood is about 142nanogam/ ml, achieved after 2-3 hours. Food reduces the peak concentration in plasma by about 17% but does not slow down the time to reach the peak concentration of the drug.

    The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha 1 - Glycoprotein acid. The distribution volume is 5.4 - 5.8 liters/kg. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolism of terfenadin in breast milk.

    Fexofenadin does not pass the blood - brain barrier. Approximately 5% of the dose of the drug is metabolized. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

    Half of Fexofenadin elimination is about 14.4 % hours, longer in renal failure people. The drug excreted mainly in feces (approximately 80%), 11 - 12% of the dosage is eliminated through urine in constant form.

    Before taking Fexofenadin 120-HV USP medicine treats allergic rhinitis, chronic urticaria (10 blisters x 10 tablets)

    How to use

    drugs used by oral.

    Take the tablet with a glass of water.

    Dosage

    Allergic rhinitis

    adults and children over 12 years old

    Take 1 capsule/time/day.

    Standing chronic urticaria

    adults and children over 12 years old

    Take 1 capsule/time/day.

    Patients with kidney function

    Take 1 capsule/time/day.

    Elderly and liver failure

    No dose adjustment.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Use conventional measures to remove unprocessed drugs in the digestive tract. Support support and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using Fexofenadin 120, you may experience unwanted effects (ADR).

    In control clinical studies, the unwanted effect rate in the patient group using Fexofenadin is similar to the Placebo group. The unwanted effects of the drug are not affected by the dosage, age, gender and race of the patient.

    Common

    Neurological: Drowsy, tired, headache , insomnia, dizziness.

    digestive: nausea, indigestion .

    Other: viral infections (colds, flu), dysmenorrhea, upper respiratory infection, itching throat, cough, fever, otitis media, sinusitis and back pain.

    rarely

    Neurological: Fear, Sleep disorders , nightmares.

    Digestive: dry mouth, abdominal pain.

    rarely

    Skin: rash, urticaria, itching.

    Hypersensitivity reactions: Evala, chest tightness, shortness of breath, redness, anaphylaxis.

    How to handle

    The unwanted effects of the drug are usually mild, only 2.2% of patients have to stop the drug due to the unwanted effects of the drug.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Fexofenadin 120 drug contraindicated in the following cases:

  • Patients with a history of hypersensitivity to fexofenadin.
  • Patients under 12 years old.

    • Driving and operating machinery

    The drug is less likely to be drowsy, but still need to be cautious when operating machinery or driving train.

    Pregnancy and nursing mothers

    Caution for pregnant women, nursing women. Only use when really necessary.

    Drug interaction

    Fexofenadin is not transferred in the liver and thus not interacting with metabolic drugs in the liver. Safety when used combined with fexofenadin with erythromycin and ketoconazole , do not cause torsion syndrome, a common side effect when combining the first -generation histamine antagonists with erythromycin and ketoconazole. However, the concentration of fexofenadin in plasma doubled after being used with erythromycin or ketoconazole.

    Anti -acid contains aluminum Hydroxyd and Magnesi Hydroxyd gel reduces the bioavailability of Fexofenadin, due to the connection of the gastrointestinal tract. These drugs should be taken at least 2 hours apart.

    Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

    To be out of reach of children.

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    Disclaimer

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    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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