Fexofenadine Hydrochloride 180mg An Thien treatment of allergic rhinitis (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Fexofenadin hydrochlorid

Ingredient

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Composition information	Content
Fexofenadin hydrochlorid	180mg

Uses

indications

Fexofenadine hydrochloride 180mg medicine used in adults and children aged 12 and older to:

Treatment of symptoms in seasonal allergic rhinitis: sneezing, runny nose, itchy nose, watery eyes, red eyes, itchy palate and throat. H1.

ATC code: R06AX26.

Fexofenadin is a second -generation antihistamine, which has a specific antagonistic and selective effect on peripheral H1 receptors. The drug is a metabolic substance that has the activity of terfenadin, also competing with histamines at H1 receptors in the digestive tract, blood vessels and respiratory tract, but there is no toxicity for the heart due to not inhibiting potassium channel related to myocardial cycles.

Fexofenadin has no significant effects on acetylcholin, dopamine antagonism and has no effect of inhibiting receptors A1 or ß-adrenergic. At the dose of treatment, the drug does not cause sleep or affects TKTW. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

Pharmacokinetics

absorption

Good absorption drug when taken oral and start to work after drinking 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (to about 4 hours). Anti -antihistamine effect lasts more than 12 hours.

Distribution

The ratio of the plasma protein of the drug is 60 - 70%, mainly albumin and α1 -acid glycoprotein.

It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin as a metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism

Fexofenadin is very small metabolized (about 5%, mainly in the intestinal mucosa, only about 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances). About 3.5% of fexofenadin dose metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives. This metabolic substance is only seen in the stool, so there may be the participation of intestinal bacteria in this metabolism.

Elimination

FEXOFENADIN SELLING Time is about 14.4 hours, longer (31 - 72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11 - 12%) in constant form.

Dynamic pharmacokinetics in people with renal failure

CLCR 41 - 80 ml/minute: The peak concentration is 87%, the sale time is longer than 59%. Strong.

Before taking Fexofenadine Hydrochloride 180mg An Thien treatment of allergic rhinitis (3 blisters x 10 tablets)

How to use

Fexofenadine Hydrochloride 180mg oral, drink with water, time to take the drug regardless of the meal.

Do not drink with fruit juice.

Do not overdose indicated.

Dosage

Adults and children over 12 years: Use 60 mg x 2 times/day or 180 mg x 1 time/day.

Renal failure people: The recommended starting dose is 60 mg x 1 time/day.

Hepatic impairments: No dose needed.

Elderly: No dose needed unless the kidney function is impaired.

Children under 12 years: Safe and effective of Fexofenadin Hydrochorid 180 mg in children under 12 years old has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Information about the acute toxicity of fexofenadin is limited.

However, drowsiness, dizziness, dry mouth have been reported.

How to handle

Use conventional measures to remove the unexplained medicine part in the digestive tract. Support support and treatment.

Hemolysis reduces the concentration of drugs in the blood (1.7%). There is no specific antidote.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

In controlled clinical studies, the unwanted effect rate in the group of patients using Fexofenadin is similar to the use of Placebo. The unwanted effects of the drug are not affected by the dosage, age, gender and race of the patient.

Common, 1/100 ≤ ADR

neurological disorders: Sleep, headache, dizziness.

Digestive disorders: Nausea, indigestion.

Common disorders and at the place of use: fatigue.

Immune system disorders: Hypersensitivity reactions to angioedema, chest tightness, shortness of breath, redness, anaphylaxis. jute, itching.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Fexofenadine hydrochloride 180mg contraindications in the following cases:

Hypersensitivity to fexofenadin, terfenadin or any ingredients of the drug.

Be cautious when using

for patients with a history of cardiovascular disease, so it is warned that antihistamine drug groups can cause unwanted effects such as tachycardia, broken chest drum.

Be careful and adjust the appropriate dose when using drugs for people with impaired renal function because the concentration of drugs in plasma increases due to prolonged semi -waste time.

Be cautious when taking medicine for the elderly (over 65 years old) because there is often a impaired renal function.

Safety and effectiveness of Fexofenadin Hydrochorid 180 mg in children under 12 years of age has not been determined.

Need to stop Fexofenadin at least 24 - 48 hours before conducting antigen tests on the skin.

Use fexofenadin blue psoriasis.

Do not take antihistamine other drugs when taking fexofenadin.

Autodity warning

Lactose-containing excipient ingredients, patients with rare genetic problems such as galactose intolerance, Lapp Lactase deficiency or Glucose-Galactose should not be used.

Use drugs for women during pregnancy and lactation

Pregnant women

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the maternal benefits are superior to the risk of the fetus.

breastfeeding women

It is unclear whether the drug is excreted through breast milk, although it has not seen unwanted effects in infants when breastfeeding mothers use fexofenadin, but still need to be cautious when using fexofenadin for breastfeeding women.

The effect of the drug on the ability to drive and operate machinery

Although Fexofenadin is less drowsy, but still need to be cautious while driving, control machines or perform activities that require alertness.

Drug interaction

erythromycin and ketoconazole increases fexofenadin levels in plasma but does not change the QT range.

Fexofenadin concentration may be increased by erythromycin, ketoconazole, verapamil, p-glycoprotein inhibitors.

Do not simultaneously use fexofenadin with antacids containing aluminum, magnesi because it will reduce the absorption of fexofenadin. Fexofenadin should be used for 2 hours away from antacids containing aluminum, Magnesi.

Fexofenadin may increase alcohol content, central nervous sedatives (TKTW), anti -cholinergic substances.

Fexofenadin may reduce the concentration of acetylcholininology inhibitors (in TKTW), Betahistin.

Fexofenadin may be reduced by concentrations by acetylcholininininiserase inhibitors (in TKTW), amphetamine, antacids, grapefruit juice, rifampin.

Cavalry

Fruit juice (oranges, grapefruit, apples) can reduce the bioavailability of fexofenadin by 36%. Avoid using fexofenadin with ethylic alcohol (alcohol) because it increases the risk of sedation (sleep).

Storage

Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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