Fixnat 100 Hasan Treatment Treatment of infection (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Cefpodoxim

Ingredient

Composition information	Content
Cefpodoxim	100mg

Uses

indications

Fixnat pills are indicated in the following cases:

Mild to moderate lower respiratory infections: including acute pneumonia, acute drama of chronic bronchitis. Grant, inconstatable, endometriosis or anus - rectum of women, gonorrhea in the urethra of women and men.

The antibacterial effect of Cefpodoxim Proxetil through inhibition of bacterial cell synthesis thanks to the acylification of transpeptidase enzymes that connect membrane, prevent the cross -linking of peptidoglycan chains necessary for the strength and durability of bacterial cell walls.

antibacterial spectrum

Cefpodoxim is an antibiotic of the 3rd generation cephalosporin group, sustainable with beta-lactamase created by Gram-negative and Gram-positive bacteria.

Cefpodoxim has the activity of Gram-positive bridge such as pneumococcus (Streptococcus pneumoniae), streptococcus streptococcus streptococcus (streptococcus) group A, B, C, G and with staphylococcus aureus, S. Epidermidis whether or not to produce beta-lactamase. However, the drug has no anti -staphylococcus effects against isoxazolel - penicillin due to changes in penicillin -mounted proteins.

Cefpodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has anti -gram -negative anti -bacteria such as E.coli, Klebsiella, Proteus Mirabilis and Citrobacter.

Cefpodoxim has little effect on Proteus vulgaris, Enerobacter, Serratia Marcescens and Clostridium perfringens. These bacteria are sometimes completely resistant.

Staphylococcus a staphylococcus of methicillin, Staphylococcus saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas spp Completely cephalosporin.

Pharmacokinetics

absorption

Cefpodoxim Proxetil is absorbed through the gastrointestinal tract, maybe in the intestinal wall, the metabolic of Cefpodoxim metabolites works.

Birth of Cefpodoxim is about 50%, increased bioavailability when using Cefpodoxim with food. After taking a dose of Cefpodoxim, in healthy adults, there is normal kidney function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/ml, 3.9 micrograms/ml for doses of 100 mg, 200mg, 400mg.

Distribution

about 40% Cefpodoxim binds to plasma proteins.

Metabolism

Metabolized by non -specific esters.

Elimination

The sale time of Cefpodoxim is 2.1 - 2.8 hours for patients with normal kidney function. The selling time increases to 3.5 - 9.8 hours in people with kidney disabled.

The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults and has a normal renal function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Fixnat 100 Hasan Treatment Treatment of infection (3 blisters x 10 tablets)

How to use

drink with water.

Dosage

Adults and children over 13 years old:

The acute drama of chronic bronchitis: 200 mg/time x 2 times/day, used for 10 days.

Mild mild acute pneumonia to the community: 200 mg/time x 2 times/day, used for 14 days.

Sore throat, tonsillitis mild to medium: 100 mg/time x 2 times/day, used for 5-10 days.

Mild or medium -complicated urinary tract infections: 100 mg/time x 2 times/day, used for 7 days.

Skin infections and mild and medium-complicated skin organizations: 400 mg/time x 2 times/day, used for 7-14 days.

Unexpectedly complicated gonorrhea in men and women; Gonorrhea - Rectal and endothelial cervix in women: 1 single dose 200 mg Cefpodoxim, followed by oral doxycyclin treatment to prevent chlamydia infection.

Children:

Acute otitis media in children from 5 months old to 12 years old: 5 mg/kg (maximum 200 mg) cefpodoxim, 2 times/day or 10 mg/kg (maximum 400 mg), once a day, for 10 days.

Bronchitis/mild and medium-sized tonsillitis in children 5 months to 12 years: 5 mg/kg (maximum 100 mg), 2 times/day, for 5-10 days.

To treat other infections for children under 15 days of age: Do not use.

From 15 days to 6 months: 8mg/kg/day, divided 2 times.

From 6 months to 24 months: 40mg/time, 2 times a day.

From 3 years old to 8 years old: 80mg/time, 2 times a day.

over 9 years old: 100mg/time, 2 times a day.

People with kidney failure:

Must reduce the dose depending on the degree of renal failure. For patients with creatinine clearance less than 30 ml/min, and no blood separation, common dose, 24 hours apart. Patients who are getting hemorrhage, oral doses are often used 3 times/week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Symptoms due to overdose of drugs may vomit, vomit, epigastric pain, diarrhea. In case of severe poisoning reactions due to overdose, stop treatment with cefpodoxim, hemolysis or peritoneal can help remove Cefpodoxim from the body, especially when the renal function is impaired.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fixnat, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Body: headache, rash, urticaria, itching.

Uncommon, 1/1000

Chemistry: liver enzyme disorders, hepatitis, temporary jaundice.

Body: serum with rash, fever and joint pain, anaphylactic reaction, diverse erythema

Rare, 1/10000

Blood system: Eosperus hypernagus, blood disorders.

TKTW: Increase activity, agitation, difficulty sleeping, confusion.

Urinary trend: interstitial nephritis.

Systemic: Increase tone and dizziness, dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Do not use cefpodoxim for patients allergic to cephalosporin and patients with porphyrin metabolic disorders.

Be cautious when used

Before starting treatment with cefpodoxim Proxetil, the patient's allergic history is carefully investigated with cephalosporin, penicillin or other drugs.

Be cautious for people who are sensitive to penicillin, kidney and pregnant or nursing mothers.

Need to think of fake colitis in patients with diarrhea after taking Cefpodoxim Proxetil.

The ability to drive and operate machinery

There is no data on the effect of the drug on the ability to drive and operate machinery.

Pregnancy

There is no document about using Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

breastfeeding period

cefpodoxim is secreted through low concentrations. Despite low concentrations, there are still 3 problems that will occur for breastfed children with cefpodoxim: Disorders of intestinal bacteria, directly acting to the child's body and bacterial culture results will be wrong if they have to make antibiotics when fever.

Drug interaction

Cefpodoxim absorption decreases when there is antacids or antihistamine H2, so avoid using cefpodoxim with these drugs.

When indicating Cefpodoxim Proxetil simultaneously with the compound known to be toxic kidney, should monitor the kidney function closely.

Cefpodoxim concentration in plasma increases when indicating cefpodoxim Proxetil with probenecid.

Storage

Store in a dry place, below 30 ° C, avoid light.

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