Flagentyl Sanofi treatment for urethritis, vaginitis (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Scnidazole

Ingredient

Composition information	Content
Scnidazole	500mg

Uses

indications

Flagentyl 500 mg drug contains the active ingredient scnidazol, which is a specifically anti -parasitic drug, which is anti -monomers including amoeba, giardia, trichomonas; Used in the following cases:

Urethritis, trichomonas vaginalis vaginitis.

Amib disease.

Liver amib disease.

Giardia infection.

Pharmacology

Properties: antibiotics, kill bacteria, kill unicellular organisms, belong to Nitro - 5 - Imidazol.

scnidazole in terms of general structure like nitro - 5 - imidazol, metronidazol is commonly used and Tinidazol.

These drugs share a street that works against microorganisms (anaerobic and animal bacteria) and is especially effective in the treatment of amib disease, Giardia disease, trichomonas infection and bacterial vaginitis. The mechanism of action is bactericidal through toxic metabolites and then destroys the DNA chain of bacteria and animal raw animals.

pharmacokinetics

scnidazol is quickly absorbed after drinking.

Peak concentration in plasma is about 43.9 g/l 5 hours after taking 2 g 2 g scnidazol or 30 mg/kg body weight in children. SCNidazol is the first nitro - imidazole to have a 3 -day effect on the solicitor -to -killing organism with only one dose. With a selling time about 17 - 29 hours long, SCNidazol effectively treated and helped improve the adherence of patients due to short -effective time with good treatment effect.

The drug penetrates the placenta, into breast milk. With a low ratio of plasma (15%), the distribution of secnidazole is fast throughout the body, the central nervous system and mucus, the concentration of drugs outside the blood vessels and in the similar tissue in plasma concentrations. Slow elimination, mainly through urine (50% of the dose is eliminated in 120 hours).

Before taking Flagentyl Sanofi treatment for urethritis, vaginitis (1 blister x 4 tablets)

How to use

Flagentyl 500 mg oral drug.

Dosage

Urethritis and vaginitis caused by Trichomonas Vaginalis

Adults: Take a single dose of 4 capsules (ie 2 g), drink before meals. At the same time, people have sex with the same dose (2 g).

intestinal amib disease

AMIB infection (with Entamoeba Histolytica):

Adults: Take a single dose of 4 capsules (ie 2 g), drink before meals.

Children: 30 mg/kg/day, drink into a single dose. Treatment time is only one day.

asymptomatic amib infection (with cysts and forma):

Take the dose as above for 3 days.

Liver amib disease

Adults: 3 capsules/day (ie 1.5 g/day), drink once or divide into several times a day before meals, drink for 5 days.

Children: 30 mg/kg/day, taken once or divided into several times a day before meals, drink for 5 days.

Note: During the period of liver amoeba disease, pus must be carried out from the abscess at the same time with SECNIDAZOL treatment.

Giardia infection

Adults: 4 tablets (equivalent to 2 g), take 1 single dose.

Children: 30 mg/kg/day, a single dose.

The type of oral solution is recommended for children under 6 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Sednidazole can be eliminated by causing vomiting, gastric lavage, activated carbon or accelerating substance. Controlling convulsions with diazepam and phenytoin.

What to do when you forget 1 dose? However, if it is close to the next dose, skip this forgotten dose and take the next dose to the prescribed prescription. Do not take double the dose to compensate for the forgotten dose.

If you need more information about your doctor or pharmacist.

Side Effects

When using Flagentyl 500 mg, you may experience unwanted effects with many changes in some patients (ADR).

Gastrointestinal disorders (nausea, vomiting, stomach pain), have a metal taste in the mouth, inflammation of the tongue, stomatitis.

Rarely seal the hypersensitivity reactions: fever, rash, urticaria and microchip (swelling of the face).

rare: dizzy, neurological disorders of sensory and movement.

Moderate leukopenia (abnormal leukemia), and recover to normal after stopping the drug.

Instructions for handling ADR

If you have any side effects, inform your doctor or pharmacist, including the effects that have not been listed in this user manual. When reporting side effects, you will help provide information about the safety of this drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated 2>

Flagentyl drugs 500 mg contraindicated in the following cases:

Hypersensitivity to the derivatives of imidazole or any ingredients of the drug.

during breastfeeding.

allergies to flour (a condition difference from gluten -absorbing syndrome).

Be cautious when using

Do not drink alcohol during treatment with secnidazol.

Do not use this drug in patients with a history of blood disorders.

Can use this drug in patients with gluten intolerance. Wheat starch can contain gluten, but only very small quantities, and therefore should be considered safe for people with abnormal syndrome gluten.

The ability to drive and operate machinery

very rare cases of dizziness are reported after using imidazole derivatives. Pay attention, especially when driving and operating machinery, with the risk of dizziness related to the use of this drug.

Pregnancy

There is currently no relevant clinical data to assess the birth of monster or toxicity for secnidazol's pregnancy when using the drug during pregnancy. Therefore, for precautions, it is best not to use secnidazol during pregnancy.

breastfeeding women

There is no data related to the excretion of breast milk. However, the excretion of breast milk is proven with other imidazol derivatives, and cases of candidiasis infections in the anus or mouth and diarrhea in breastfed babies of mothers who are being treated with imidazol derivatives have been described.

Therefore, clinical monitoring of breastfed babies, or even stop breastfeeding during this treatment.

Drug interaction

Do coordinates are not used

disulfiram: acute transient illusion disorders, hallucinations.

alcohol: anti -abuse effects (redness, vomiting, heart rate). Alcohol or alcohols must be avoided.

The coordination must be cautious when used

Warfarin: Warfarin drugs (Warfarin) The treatment time is capable of reducing the metabolism of warfarin in the liver, thereby increasing the risk of bleeding. Prothrombin and Inr monitoring must be checked. The dose must be adjusted for oral anticoagulants during treatment with secnidazol and up to 8 days after stopping this drug.

Storage

Store in a dry place, avoid direct light, at a temperature not exceeding 30 ° C.

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