Flagyl 250mg medicine Sanofi treatment infection (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Metronidazole

Ingredient

Composition information	Content
Metronidazole	250mg

Uses

indications

Flagyl 250 mg drug is indicated in the following cases:

Treatment of bacterial infections caused by trichomonas vaginalis, nonspecific vaginitis, amoeba infection, Giardia infection, anaerobic microorganism infection.

Pharmacokology

Metronidazol has the following pharmacological properties:

Kill sensitive bacteria such as Gram -negative aerobic bacteria: Helicobacter pylori. Peptostreptococcus, Prevotella, Prophyromonas, Veillonella. It will be helpful to collect information about local drug resistance ratio, especially in the treatment of severe bacterial infections. The peak of plasma concentration is achieved after drinking the same as after intravenous injection at the same dose.

Oral bioactivity is 100%.

About 1 hour after taking a single dose of 500 mg, the average maximum concentration in plasma is 10 micrograms/ml. Semi -cancellation time in plasma is from 8 to 10 hours.

The drug is distributed quickly and widely, with concentrations close to the concentration of serum, lungs, kidneys, liver, skin, bile, cerebrospinal fluid, saliva, semen, vaginal discharge. The drug goes through the placenta and is secreted into breast milk.

The drug is metabolized mainly in the liver with oxidation.

The main excretion drug in the urine in the form of metronidazol and the metabolites in the urine account for about 35 - 65% of the drug used.

Before taking Flagyl 250mg medicine Sanofi treatment infection (2 blisters x 10 tablets)

How to use

Sugar used: Take oral medication. Swallowing pills with a little water.

Dosage

thoroughly comply with the recommended dose, unless other physicians have other opinions.

Amoeba infection

Adults and children over 15 years old: Take 1.5 g/day divided into 3 drinks.

Children: Take 30 to 40 mg/kg/day divided into 2-3 times a day.

Children from 6 - 10 years old: Take 500 mg/day. Oral Metronidazole is more suitable for this age group of children. In the case of liver abscess due to amipar, drainage or pump pump, it should be done in combination with Metronidazol treatment.

Trichomonas infection

Women (urethritis and vagina caused by trichomonas): 10 -day treatment process when coordinating other treatment: Take 500 mg/day divided into two oral times.

Must treat your partner at the same time, whether or not there is any clinical signs proving that there is Trichomonas Vaginalis infection, even if negative subclinical tests.

Men (trichomonas urethritis): Take 500 mg/day divided into twice in 10 days.

In some cases, daily dose can be increased to 750 mg or 1 g.

Giardia infection

Adults and children over 15 years: Take 750 mg to 1 g/day.

Children from 6 to 10 years old: 375 mg/day. Metronidazole pills are more appropriate for this age group of children.

Children from 11 to 15 years old: 500 mg/day.

Daily dose is only taken once or divided into two times, preferably drinking for meals for 5 consecutive days.

Non -specific vaginitis

Women: Take 1 g/day divided into twice, drink for 7 days. Must treat your partner at the same time.

Anaerobic bacteria are still sensitive (initial treatment or treatment from injection to orally)

Adults and children over 15 years old: 1 g to 1.5 g/day, divided into 2-3 times a day.

Children: take 20 to 30 mg/kg/day, divided into 2-3 times a day.

Children from 6 to 10 years old: 375 mg/day. Metronidazole pills are more appropriate for this age group of children.

Children from 11 to 15 years old: 500 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Take a single dose of up to 12 g of metronidazol that has been recorded in suicide or overdose. The millions of them may be encountered include: vomiting, loss (loss of coordination), slight orientation, dry mouth, trend of fainting of hot flashes, skin rashes, headaches, mild depression, reduced taste, and nausea.

Handling

There is no specific antidote. In case of overdose, gastric lavage should be conducted and symptomatic treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Flagyl 250 mg, you may experience unwanted effects (ADR).

Stomach -intestinal disorders: epigastric pain, nausea, vomiting, diarrhea. Oral mucosa, change taste, anorexia. Some rare cases of pancreatitis but can be reversed. Change the color of the tongue/tongue with so (for example, due to excessive growth).

immune system disorders: angioedema, anaphylactic shock.

Nervous system disorders: Neuropathy peripheral sensory. Headache, convulsions, dizziness. There are reports of enhancement (such as confusion), semi -acute cerebellar disease (such as ventricular movement) that can be resolved by stopping the drug. Aseptic meningitis.

Mental disorders: Symptoms of psychosis include confusion and hallucinations. Depression state.

visual disorders: transient visual disorders. Pathology/optic neuritis.

Disorders of red blood cells and leukocytes: A very rare number of cases of granulocytes, neutrophils and platelets.

Liver disorders: Some cases of liver enzymes, hepatitis bile or mixed and liver cell damage, sometimes jaundice. Some cases of liver failure required liver transplant have been reported in patients treated with metronidazol in combination with some other antibiotics.

Disorders in the skin and subcutaneous tissue: rash, itching, blushing, urticaria. Rash pustules. Stevens - Johnson syndrome, epidermal necrosis due to toxins.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Flagyl drug 250 mg is contraindicated in the following cases:

hypersensitivity to imidazol and/or any excipients of the drug.

Caution when using

If there is a good reason to use Metronidazol longer than the recommended treatment time, should be regularly tested for hematology, especially the number of white blood cells, and patients need to monitor side effects such as peripheral neuropathy or central (such as abnormalities, loss, dizziness, convulsions).

recommend that patients should not drink alcohol during treatment and at least 24 hours after the end of treatment because of the possibility of a disulfiram reaction (ie, redness, redness, vomiting and tachycardia).

Should be cautious when using Metronidazol if there are central or severe nervous system diseases that are active or chronic because of the risk of increasing neurological symptoms.

Red -brown urine may occur during treatment but not causing any consequences. Be cautious when taking Metronidazol for patients with brain disease due to liver failure.

The ability to drive and operate machinery

because of the risk of confusion, dizziness, hallucinations, convulsions or visual disorders, it is accompanied by the use of drugs, so patients should not drive or control machines if these symptoms occur.

Pregnancy

metronidazole causes mutations to bacterial cells and cancer for mice experimental. Metronidazol passes the placenta with the same concentration of drug concentration in the mother's plasma. The use of pregnancy still argues. The general analysis of the use of metronidazol in the first 3 months of pregnancy concludes that the drug does not increase the risk of monitoring.

However, according to the product information licensed in the United States mentioned Metronidazol is contraindicated in the first 3 months of pregnancy on Trichomonas infection, while being accepted for use in the three months between pregnancy.

For other indications, it is necessary to consider the benefits and risks when treating with metronidazol, especially in the first 3 months of pregnancy.

The period of breastfeeding

metronidazole through breast milk causes bitterness, making it difficult for children to breastfeed. Metronidazole is unknown for breastfeeding; However, to safely advise to stop breastfeeding for about 12 - 24 hours when taking 1 single dose.

Drug interaction

disulfiram: If you are using disulfiram, you should not use Metronidazol at the same time or at least within two weeks after the end of Disulfiram treatment, as it can lead to acute and confused hallucinations.

Alcohol: Avoid drinks or alcohol -containing drugs because there may be many unpleasant reactions, called disulfiram -like effects, including: hot, skin redness, vomiting, nausea, foul -pouring and hitting chest drum.

Anticoagulant oral medication (Warfarin type): Increases the risk of bleeding, as metronidazole increases the effect of this drug. In the case of simultaneous use, monitor Prothrombin regularly and adjust anticoagulant therapy during the treatment period with metronidazol.

Lithium: Serum lithium concentration can increase due to metronidazol. Lithium, creatinine and electrolyte serum levels should be monitored in lithium treatment patients while they use Metronidazol.

cyclosporin: The risk of increasing serum cyclosporin levels. Serum concentration of cyclosporin and creatinine should be closely monitored when it is necessary to use metronidazol simultaneously.

Phenytoin or phenobarbital: Increased elimination of metronidazol leads to reduced serum metronidazol levels.

5 - Fluorouracil: reducing clearance 5 - Fluorouracil leads to increased toxicity of 5 - fluorouracil.

Busulfan: Serum Busulfan concentration can be increased by Metronidazol, which can lead to serious Busulfan poisoning.

Storage

Store drugs at temperatures not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.