Flexidron 60 Abbott drugs reduce symptoms of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etoricoxib

Ingredient

Composition information	Content
Etoricoxib	60mg

Uses

indications

Flexidrons are indicated in the following cases:

Reduces symptoms of osteoarthritis, rheumatoid arthritis and joint vertebrae. Anti -inflammatory properties, analgesic, and fever in animal models. Etoricoxib is a strong, very selective Cycloxygenase-2 inhibitor (COX-2), which is active when taken within the scope and is higher than the clinical dose range.

Determined two forms of cyclooxygenase: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Cox-1 is responsible for normal physiological functions through prostaglandin intermediaries such as protecting the gastric mucosa and platelet aggregation. Cox-1 inhibition due to non-selective NSAIDs is often accompanied by stomach lesions and platelet aggregation. Cox-2 has been shown to be mainly responsible in the synthesis of the intermediate substances of prostanoic acid that causes pain, inflammation and fever. The selective inhibition of COX-2 by Etoricoxib (within the clinical dose range) reduces these clinical signs and symptoms along with reducing the toxicity in the digestive tract and does not work on platelet aggregation.

Dynamic pharmacokinetics

Etoricoxib is well absorbed through the gastrointestinal tract after drinking. Peak concentration in plasma is reached for about 1 hour and the ratio of cohesion to plasma protein is about 92%. In a stable state, Etoricoxib's half -life is about 22 hours. Etoricoxib is metabolized and less than 2% of the dose is found in the urine in the form of mother medicine.

The main transformation path is through the isoenzyme cytochrome P450 (CYP) including CYP3A4 to form Etoricoxib's 6 -Hydroxymethyl derivative, which is then oxidized into 6 - -Carboxylic derivatives, main metabolites. Both of these substances are not active or just weak COX-2 inhibitors. The excretion is mainly through urine (70%), only 20% of the dose is found in feces.

Before taking Flexidron 60 Abbott drugs reduce symptoms of osteoarthritis, rheumatoid arthritis (3 blisters x 10 tablets)

How to use

flexidron is used by oral and can be used or not with food. Starting impact faster when taking the drug when hungry. This should be considered when it is necessary to quickly reduce symptoms.

Dosage

recommended dose:

osteoarthritis: 60 mg/day/day.

rheumatoid arthritis and joint vertebrae: 90 mg/time/day

Acute phosphorus arthritis; Acute pain includes primary dysmenorrhea and pain in small teeth: 120 mg/time/day. Etoricoxib should only be used only in acute symptoms, with a maximum treatment time of 8 days.

Acute pain includes primary dysmenorrhea and pain in small teeth: 120mg once a day. Etoricoxib should only be used only in acute symptoms, with a maximum treatment time of 8 days.

kidney failure: No dose adjustment for patients with creatinine clearance ≥ 30 ml/min. Contraindicated to use Etoricoxib for patients with creatinine clearance

Hepatic failure: Patients with mild liver failure: 60mg once a day. Patients with average liver failure: 60mg 2 days. Etoricoxib should not be used for patients with severe liver failure.

Used in children: Safety and effectiveness of drugs in children who have not been proven.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

In clinical trials, Etoricoxib is used for a single dose of up to 500mg and doses to 150mg/day for 21 days without significant toxicity. There have been reports on the use of acute Etoricoxib but there is no report on adverse effects occurring in most cases of overdose. The most common adverse effects recorded are in line with the safety characteristics of Etoricoxib (on the digestive tract, kidney blood vessels).

Handling

In case of overdose, the common supportive measures should be applied such as removing substances that have not been absorbed from the gastrointestinal tract, clinical monitoring, support treatment if necessary. Etoricoxib cannot be removed by hemolysis, it is still unknown whether it is possible to use peritoneal fertilizer to remove Etoricoxib.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using flexidilerrons, you may experience unwanted effects (ADR).

The most unworthy effect is related to Etoricoxib therapy including digestive disorders, cases of ischemic heart, hypersensitivity reaction, headache, dizziness, nervousness, depression, drowsiness, insomnia, dizziness, tinnitus, light sensitive, blood disorders, water hypertension, hypertension, dry mouth, taste disorders, chest pain, pain, fatigue Influenza, muscle pain, and kidney toxicity.

Risk of cardiovascular thrombosis.

Stop using and consulting your doctor if: Signs of the symptoms of liver poisoning or the first signs of the hypersensitivity appear.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Flexidrons are contraindicated in the following cases:

Patients with hypersensitivity to Etoricoxib or any ingredients of the drug.

Caution when using

should not be used with any other drug containing Etoricoxib.

Should avoid using Etoricoxib in patients with severe liver failure.

Should be cautious when taking medication for patients with significant risk factors for cardiovascular disease or peripheral artery disease.

Etoricoxib, especially at high doses, may be more related to more severe and more frequent hypertension than other NSAIDs and other COX-2 inhibitors. Need to monitor blood pressure during treatment with Etoricoxib.

Do not use for hypertension patients with untreated blood pressure.

Be careful when using Etoricoxib in patients with dehydration, so rehydration for patients before using Etoricoxib.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, Flexidron 60 is needed at the lowest daily dose to be effective in the shortest possible time.

Use in children: Safety and effectiveness of drugs in children who have not been proven.

The effect of drugs on driving and operating machinery

There is no research on the effect of Etoricoxib on the ability to drive or operate machinery. However, the patient has been dizzy, face or sleeping while using etoricoxib should avoid these activities.

Use drugs for women during pregnancy and nursing mothers

used in pregnant women: There are no controlled studies on pregnant women. This drug should only be used when benefits are higher than the risk that can occur to the fetus. In the last 3 months of pregnancy or near the date of birth: There is evidence related to the risk in the fetus, but due to the benefit, the use of drugs during pregnancy may be accepted, despite the risk (as needed in life -threatening situations or in a serious illness, which is safer to use or ineffective).

Used in breastfeeding women: There is no information on Etoricoxib excretion in breast milk. However, it is necessary to stop breastfeeding if the treatment is necessary.

Drug interaction

Etoricoxib's metabolism via ISoenzyme Cytochrome P450 CYP3A4. Used with other drugs inhibitors or isoenzyme induction can change the Etoricoxib concentration in plasma.

Rifampicin, a strong induction of cytochrome p450 (CYP), reduces the plasma concentration of etoricoxib.

Etoricoxib is an active inhibitor of sulfotransferase in humans and has been shown to increase the plasma concentration of Ethinylestradiol.

Interaction with other drugs (oral salbutamol and oral minoxidil) are also metabolized by these enzymes, which can occur and be careful with such combination.

Low -dose aspirin use at the same time with Etoricoxib increases the rate of gastrointestinal ulcers or other complications compared to when using Etoricoxib monomers.

Etoricoxib may increase lithium concentration in plasma.

Oral contraceptives: Etoricoxib may increase Ethinyl estradiol level.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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