Flodicar MR 5mg Pymepharco medicine for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Felodipine

Ingredient

Composition information	Content
Felodipine	5mg

Uses

indications

Flodicar drug indicated in the following cases:

Treatment of hypertension. At low concentrations, calcium inhibitors enter smooth muscle cells. Therefore, felodipine acts on the physiological and mechanical electrical process (inhibiting the stimulating pair - muscle contraction) should reduce the artery tone, leading to vasodilation effect to lower blood pressure. Stretching into arteries increases the diameter of the arteries and maintains, sometimes increases blood flow in the region (coronary artery, kidney, brain), mild diuretic, sodium excretion and does not hold water and salt when long -term treatment.

Due to the high selection on the plain muscle of the artery, Felodipine at the dose does not work directly on the cardiac contraction or transmission. Due to no effect on venous muscles or on sympathetic vascular control, Felodipine does not cause hypotension.

Felodipine has an anti -angina effect by improving the balance in the supply and oxygen of the heart muscle. Coronary artery flow as well as oxygen supply for the heart muscle increases thanks to the coronary artery. Felodipine reduces systemic blood pressure should reduce the left ventricular burden, thus reducing the oxygen demand of the heart muscle.

Felodipine increases exertion and reduces the number of angina pain in patients with stable angina. The drug can be used alone or in combination with a beta blocker. Like other calcium blockers, Felodipine does not affect glucid and lipid metabolism and does not change the ratio of components between plasma lipid lipids. Felodipine can be used for people with diabetes or gout.

pharmacokinetics

Felodipin absorbed 98 - 100% by gastrointestinal tract after oral oral medication initially in the liver mainly thanks to CYP3A4 and bioavailing is about 10 -25%. Felodipine absorption speed increases when taking the medication at meals and the maximum concentration of the drug's blood increases by 60% when Felodipin is taken with a meal with high carbohydrates and fats; There have been monitoring shows that the pharmacokinetics of the drug have not changed when Felodipin is taken with a snack.

The time to reach the peak concentration in the serum when used orally is 2-5 hours, half -life of Felodipine is 11 - 16 hours (depending on the name of the drug), but all types of tablets containing Felodipin are only used once a day.

There is no significant medicine accumulation when taking the drug for a long time.

The drug is strongly metabolized through the liver and the main issue (about 70%) in the form of metabolites that do not work through the urine, the rest has not metabolized excreted through feces. About 99% felodipine in the blood are linked to protein, mainly albumin. Felodipin is also excreted in breast milk.

Before taking Flodicar MR 5mg Pymepharco medicine for hypertension (3 blisters x 10 tablets)

How to use

Flodicar should be taken in the morning, should be taken with a snack, swallowed with plenty of water and not broken down, grinded or chewed.

Dosage

Dosage for hypertension treatment:

The dose is adjusted by each patient. If necessary, the dose can be increased or added another medication to treat hypertension. The usual maintenance dose is 5 - 10 mg/day.

should adjust the dose for each patient. The treatment should start with 5 mg x 1 time/day. If it is necessary to increase to 10 mg x 1 time/day. The maximum dose is 5mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Handling: When severe hypotension appears, symptomatic treatment is required. Patients should be placed on their backs, high legs. If the heart rate is needed to be injected with intravenous atropine 0.5 - 1 mg. If not effective, it is necessary to increase the volume of plasma with a transmission solution such as glucose, physiological saline or dextran. The sympathetic neurological medications have a stronger effect on the alpha-1 receptor (isoprenalin, dopamine or noradrenalin) that can be used if all of the above measures are not effective.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Felodipine can cause blushing, headache, brushing chest, dizziness and fatigue. Most of these reactions depend on the dose and appear at the beginning of treatment or after increasing the dose. When it happens, these reactions rewarded and decreased over time.

Like other dihydropyridin, they edema depending on the dose that occurred in patients using Felodipin. This is due to capillary expansion and not related to any congestion.

Gingiveness or gum hypertrophy has been recorded in patients with periodontitis or gingivitis. This phenomenon can be avoided or restored by careful oral hygiene.

The following adultery reactions are recorded from clinical trials and from research after being brought to the market.

Conventions on frequency are as follows:

Common: ≥ 1/100.

Common: headache

Common: blush, peripheral edema.

Less: Nausea, abdominal pain.

Rare: vomiting.

Very rare: increased liver enzymes.

Skin and subcutaneous tissues:

Uncommon: rash, itching.

Rare: urticaria.

Rare: joint pain, muscle pain.

Rare: Pying.

Genital system:

Rare: Impotent or genital dysfunction.

Body:

Less: fatigue.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Flodicar medicine is contraindicated in the following cases:

Hypersensitivity to dihydropyridine and the ingredients of the drug. Drug intake in children has not been determined.

Caution when using

Efficiency and safety of Felodipine in the treatment of unexplained emergency hypertension.

Felodipine can cause significant hypotension with tachycardia, which can lead to myocardial ischemia in some sensitive patients. Therefore, it is necessary to be cautious when using felodipine for the elderly. Dosage should not exceed 5 mg/day.

Felodipine is metabolized mainly through the liver. Therefore, the reactions may occur due to the higher level of drug concentration in patients with significant impaired liver function. For people with severe liver failure, the maximum dose is 5 mg/day.

Should avoid simultaneous use of felodipine with induction drugs or strong inhibition of CYP3A4 enzymes because it can lead to decreased or increased felodipine concentration in plasma significantly.

Felodipine should be used carefully in patients with tachycardia or severe left ventricular dysfunction.

Need to stop felodipine if after the beginning of treatment, angina or angina occurs or cardiova.

Do not take medicine with grapefruit juice.

Lactose -containing drugs, so it is not advisable to use for congenital galactose tolerances, with poorly absorbent glucose and galactose syndrome, or a lactase enzyme deficiency.

No need for special caution for patients with renal failure.

Gumic hypertrophy or gum hypertrophy has been reported in patients with severe periodontitis. This condition can be prevented or recovered by careful oral hygiene.

Use drugs for pregnant women or nursing women

Pregnant women: Do not use felodipin during pregnancy.

In a study of mouse fertility, there was a difficult birth phenomenon due to prolonging labor, increasing the rate of pregnancy and death immediately after birth for medium and high doses. Rabbit reproductive research shows that there is a proliferation depending on the dosage of the mammary gland in the mother rabbit, the finger defect depends on the fetus when using felodipine in the early stages of pregnancy.

Lactating women: Felodipin has been discovered in breast milk. Because there is not enough data on the impact of the drug on newborns, Felodipine should not be used during breastfeeding.

The effect of the drug on driving and operating machinery

Felodipine has a small or medium impact on the ability to drive and operate machinery. Symptoms of headache, dizziness nausea or fatigue may occur due to the unwanted effect of the drug. The most special attention is needed in the beginning of treatment with felodipine.

Drug interaction

felodipine is metabolized by CYP3A4 so CYP3A4 inhibitors (ketoconazol, iTraconazole, erythromycin, cimetidine, and some flavonoids are present in grapefruit juice) increasing felodipine concentration in plasma.

Significant plasma felodipine concentrations in patients using anti -epileptic drugs (phenytoin, carbamazepin, phenobarbital, primidon, oxacarbazepine).

Combining felodipine with intravenous dantrolen may be very dangerous because Verapamil (another calcium blocker) when combined with intravenous dancrolen leads to the phenomenon of ventricular vibration and death in experimental animals.

Baclofen enhances the blood pressure effect of Felodipine. It is necessary to monitor blood pressure and adjust the dose accordingly.

rifampicin reduces the concentration of felodipine.

Beta blockers: Use Felodipine combination with sympathetic beta blockers that can cause excessive hypotension, worsen heart failure in patients with potential or uncontrolled heart failure.

Corticosteroids reduce the anti -hypertension effect of felodipine because corticosteroids hold water and salt.

Sedative drugs: Enhance the effect of lowering blood pressure as well as the risk of hypotension.

Antidepressants Imipramin: Enhance the effect of lowering blood pressure as well as the risk of vertical hypotension. Cyclosporin, dasatinib, prostacyclin, protease inhibitors, quinuprinstin increase the effect of felodipine. Felodipine increases the effects of drugs: amifostin, substrate of CYP2C8, Magnesi salt, neurotransmitter inhibitors (anti -reducing drugs), sodium nitroprusiat, phenytoin, rituximab, tacrolimus.

Felodipine reduces the effect of clopidogrel.

Alcohol increases the absorption of felodipine thus increasing the effect.

Avoid use with ginseng, yohimb due to aggravating hypertension, avoiding garlic due to increased hypotension effect.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.