Flucinar jelfa ointment for dermatitis (15g)

Corticosteroids reduce inflammation by reducing the formation, release and limiting the effects of vasoconstrictor that is released during inflammation (kinins, histamine, Iysosom enzymes, prostaglandin, leukotriene and complementary components). Steroids reduce the permeability of cell membranes. Due to vasoconstrictor effects, fluocinolone reduces the leakage of fluid at the inflammatory place. The drug increases protein synthesis and accumulates collagen, promotes protein decomposition in the skin and slows protein proliferation.

Corticosteroids, especially corticosteroids containing fluores have the anti -cell activity of epidermal cells. The reminders of corticosteroids containing flour reduce the effects of the drug on the skin, which leads to the extension of the time for the drug to work, increase unwanted effects and increase the body absorption.

Dynamic pharmacokinetics

absorption: When used on the spot, corticosteroids on the normal skin are intact, only a small amount of drugs reach the legs and then into the general circulatory system. However, absorption increases significantly when the skin is lost, Keratin, inflamed or/and other diseases in the epidermal fence (psoriasis, eczema). Depending on the degree of permeability, the amount of topical and skin condition at the top of the drug, the drug is more absorbed in the eyelids (40%) and the scrotum (36%) compared to the forehead (7%), scalp (4%) or forearm (1%). The drug is more absorbed in the folding skin. Fluocinolone acetonide easily penetrates the skin's keratinoma where the drug is accumulated there. The presence of the drug can be found there after 15 days of applying the drug.

Metabolism: Fluocinolone acetonid is not metabolized in the skin. When the drug is used in accordance with the instructions, a small amount is absorbed into the circulatory system and is metabolized in the liver into non -active substances.

Elimination: The drug is excreted mainly through the kidneys in the form of glucuronide and sulfate, as well as in a non -combined form. A small amount of metabolic substances are eliminated through feces.

Be cautious when used

If symptoms of irritation or allergic reactions on the skin appear after applying flucinar, it is necessary to stop using the drug.

Avoid using the drug continuously for more than 2 weeks. When using long -term drugs on wide skin can increase the frequency of unwanted effects, can cause edema, hypertension, hyperglycemia (increased blood glucose level) and immunodeficiency.

Under the effect of the use of fluocinolone acetonide on the skin, reducing the excretion of the adrenal hormone (ACTH) because the pituitary gland may occur, due to the inhibition of the hypothalamus - the pituitary gland - the adrenal gland, leading to a decrease in the concentration of cortisol in the blood and causing Cushing syndrome. This condition will decrease when stopping using the drug. Periodically check the adrenal gland function by determining the concentration of cortisol in the blood and urine after stimulating the adrenal gland with ACTH.

In case of an increase in infections in the position of drug use, it is necessary to conduct treatment with appropriate antibacterial and antifungal drugs. If the symptoms of infections are prolonged, it is necessary to stop using the drug until he is out of him.

Do not allow the drug to stick to the eyes, mucosa or wounds.

Avoid using the drug in the eyelids or the skin near the eyelids in patients with narrow -angle glaucoma and wide angle, as well as in patients with opaque eye chisel because it can increase the symptoms.

Expensive use in patients with psoriasis because of skin corticosteroids may be dangerous due to a number of reasons, including recurrence due to increased drug tolerance that appears in normal pustular psoriasis and systemic toxicity due to incomplete skin.

Only use the drug on the face, armpits and groin when it is really necessary because of increased absorption and prone to unwanted effects (capillary dilatation, dermatitis around the mouth) even happening after a short time of use.

Use carefully for cases of subcutaneous atrophy, especially in elderly patients.

Flucinar ointment containing propylene glycol can be the cause of allergic reactions. Therefore, patients with a history of allergies to propylene glycol should consult a doctor or pharmacist before using the drug.

Children and adolescents: Children may increase the risk of hypothalar axial disorders - pituitary glands - adrenal glands and cushing syndrome due to the systemic effects of corticosteroids and skin surfaces of children greater than the proportion of body mass. Long -term treatment with corticosteroids can cause children's growth and development.

The ability to drive and operate machinery

The drug does not impair mental mental illness, so it does not affect the ability to drive and operate machinery.

Pregnancy

Safety level in pregnant women: type c.

Animal studies show that glucocorticoids are likely to cause teratogenicity, even when using small doses. The monster effect is also found in animals using glucocorticoids topical. There are no controlled studies when using fluocinolone acetonide on the skin for pregnant women.

Flucinar can be used for pregnant women when the benefits of using drugs greater than the risk of risk. It is recommended that the drug is not used overdose (for example, for a long time or with an amount of over 30g per week) during pregnancy.

The period of breastfeeding

Consider to stop breastfeeding or stop using flucinar based on the ability to cause unwanted effects in children and the benefits of the drug for the mother.

Unknown about the ability to excrete in Fluocinolone Acetonide's breast milk when applying this ointment on the skin.

Drug interaction

There is no known interaction related to the use of glucocorticoids on the skin. However, it should be noted that patients do not get chickenpox vaccine and other immune drugs, especially when using long -term drugs on wide skin because it can reduce the immune response.

Flucinar may increase the effects of immunosuppressive drugs and reduce the effects of immune stimulants.