Flunarizine 5mg Pharm medicine for preventive treatment migraine (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Flunarizine

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

Indications

Flunarizine 5mg medicine indicated for preventive treatment migraine in case other treatments are ineffective or ineffective.

Pharmacokological

flunarizin is the difluor derivative of piperazin, structurally related to cinnarizin.

Flunarizin has a pharmacological properties similar to cinnarizin, but has a long -term half -life in plasma so it can be treated once a day once. The effect of flunarizin is based on the selective antagonism of calcium transport flow through the cell membrane of blood vessel cells, red blood cells and brain cells.

flunarizin is thought to inhibit the calcium that enters the cells in cases of calcium entering the cell too much and damages cells due to calcium overload. Therefore, the drug is classified as an overload inhibitor. Flunarizin also inhibits smooth muscle contraction due to the entry of extracellular calcium.

The effect of flunarizin in migraine prevention is due to the ability to reduce the frequency of migraine. Flunarizin makes the level of migraine less, and does not affect the time of migraine.

Dynamic pharmacy

flunarizin is well absorbed through the gastrointestinal tract, the peak concentration of plasma is achieved within 2-4 hours. The drug is widely distributed into the tissues. The concentration of drugs in tissue, especially adipose tissue and bone tissue several times higher than plasma concentrations.

The drug attached to plasma proteins is about 90% and about 9% is distributed to blood cells, only nearly 1% exists in the form of free.

flunarizin is metabolized mainly in the liver. The disposal time of the drug lasts about 18 days, which allows only 1 time to take the drug a day.

Before taking Flunarizine 5mg Pharm medicine for preventive treatment migraine (3 blisters x 10 tablets)

How to use

Flunarizine 5mg medicine for oral use.

Dosage

recommended dose:

The usual dose is 30 - 160 mg/kg/day, depending on indications.

adults ≤ 65 years old and elderly (> 65 years):

Take a dose of 5 mg/day, take it in the evening, maintain for 4 to 8 weeks. During the treatment period, if the symptoms of depression, foreign tower or other serious adverse events appear, it is necessary to stop taking the drug.

If after 8 weeks of treatment there is no improvement, the patient is considered not responded to treatment and should stop taking the drug.

Treatment time does not exceed 6 months.

Children:

Children ≥ 12 years old, especially in the case of unexplained migraine: Doser 5 mg/day, oral in the evening. Treatment period must not exceed 6 months.

Children

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Sleep and weakness may occur. There are several cases in the overdose (high doses of 600 mg oral 1 time) have been reported, observed the symptoms: drowsiness, fast heart rate, agitation.

Management:

There is no specific antidote. Within an hour after an overdose, gastric lavage should be washed. Can use activated carbon if appropriate.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Flunarizine 5mg often has unwanted effects (ADR) such as:

Common:

Central nervous system: drowsiness, fatigue.

Central nervous system: Symptoms of foreign tower (slow movement, stiffness, restless sitting, dysplasia, tremor), depression.

Digestive: Nausea, stomach pain

Notice to the doctor the unwanted effects when using the drug.

Warnings

Before using Flunarizine 5mg, you need to read the instructions carefully and refer to the information below.

Contraindicated

Flunarizine 5mg contraindications in the following cases:

Hypersensitivity to flunarizin or any excipients of the drug.

Precautions when using

flunarizin can increase the symptoms of foreign tapes, depression and the development of Parkinson's syndrome, especially in patients at risk as elderly. Therefore, caution should be used in these patients.

During the treatment process, when you feel that fatigue increases, you must stop using the drug.

Do not use the recommended overdose. It is necessary to monitor patients regularly, periodically, especially during the maintenance treatment period to early detect expressions of foreign tapes, depression and stop treatment promptly.

Some fatigue cases with increasing severity have been recorded when using flunarizin. If this condition occurs, it is necessary to stop treating with flunarizin.

Using drugs for women during pregnancy and lactation

Pregnancy

There is no data on drug use in pregnant women, should only use the drug if the benefits are superior to the risk.

Breastfeeding period

It is unknown whether Flunarizin is distributed into breast milk or not. Consider or avoid using drugs during breastfeeding or taking medicine and stopping breastfeeding.

The effect of the drug on driving and operating machinery

Flunarizine 5mg medicine may cause drowsiness and fatigue. Therefore, use carefully for drivers, operating machinery.

Medicinal interaction

Simultaneously used alcohol, sedative and sleeping pills with flunarizin increases the side effect of drowsiness.

flunarizin is not contraindicated in patients taking beta blockers.

Flunarizin's

pharmacokinetics are not affected by Topiramat. Topiramat's stable pharmacokinetic state is not affected by flunarizin.

flunarizin does not affect the plasma concentrations of phenytoin, carbamazepine, valproat or phenobarbital. Flunarizin's plasma concentrations are often lower than that of epilepsy patients who are using epilepsy drugs compared to healthy people using similar doses. Carbamazepine, Valproat and Phenytoin's blood protein binding is not affected when using Flunarizin simultaneously.

Storage

Store in a dry place, the temperature does not exceed 30ºC, avoiding light.

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