Fluomizin Medinova vaginal placement treats vaginal fungal infections, vaginal infections (1 blister x 6 tablets)

Dosage form Vaginal tablet
Specifications Box of 1 blister x 6 tablets
Ingredient Dequilinium

Ingredient

Composition information	Content
Dequilinium	10mg

Uses

indications

Fluomizin 10 mg 1x6 is indicated in the following cases:

Vaginal fungal infection, vaginal infection (such as bacterial vaginal disease and Candida fungus).

Trichomonas disease. The quadratic has a wide -life anti -bacterial spectrum against different gram -positive and gram -negative bacteria, the fungus and the unicellular animal (trichomonas vaginalis).

In vitro activity of Dequalinium Chlorid against important vaginal microorganisms has been identified and presented according to the minimum inhibitory concentration (MIC).

mic (mg/l)

gram -positive bacteria

streptococci group B

2 - 8

0.2 - 10

0.25 - 20

listeria sp.

4 - 32

1 - 32

0.2 - 64

Mushroom

Candida Tropicalis

0.2 - 50

candida albicans

0.2 - 200

0.2 - 256

Candida Krusei

128

Gram sound bacteria

Fusobacteria

32 - 64

2.0 - 256

e. Coli

1 - 400

Serratia sp.

3,1 - 400

klebsiella sp.

3,1 - 400

pseudomonas sp.

5 - 400

64 - 512

20 -> 1024

Single animals

28.8 - 400

Not recorded the resistance of microorganisms for dequamium chlorid.

As well as other surfactants, the main mechanism of action of dequamium chlorid is to increase the permeability through cells and then lose the activity of enzymes, cause cell death.

Dequalinium Chlorid in the vagina places the vagina in the vagina. In general, the decrease in fluid secretion and decrease markedly occurs within 24 - 72 hours.

The effect of fluorine 10 mg 1x6 in the treatment of vaginal infections due to different arising has been recorded in a double -controlled blind clinical study.

Dynamic pharmacokinetics

Pre -clinical data recorded in animals shows that DEQULINIUM CHLORID is only absorbed in very small amounts after vaginal use.

recorded distribution into the liver, kidney and lungs. DEQULINIUM CHLORID seems to be converted into 2.2 'derivatives - dicarboxylic acid and is exported in non -conjugated form.

With negligible vaginal absorption, no human pharmacokinetics data for dequamium chlorid.

Clinical safety data

Consider the very little absorption of Dequilinium Chlorid through the vagina, unable to occur acute toxicity or acting field. No reproductive toxicity studies have been conducted with fluomizin 10 mg 1 x 6. However, expanded toxic studies with quadratic ammonium compounds have not seen evidence of toxicity for embryos.

Tolerance on the spot

A rabbit study has shown that fluomizin 10 mg 1 x 6 well tolerated vaginal.

Before taking Fluomizin Medinova vaginal placement treats vaginal fungal infections, vaginal infections (1 blister x 6 tablets)

How to use

Fluomizin 10 mg 1x6 used vagina.

The vagina should be deep into the vagina in the evening before going to bed. It is best to perform a lying position with slightly folded legs.

Instructions for use/manipulation

Fluomizin 10 mg6 1x6 contains insoluble excipients, the remaining drug is sometimes found in underwear. This does not affect the treatment effect of Fluomizin 10 mg 1x6.

In rare cases, the vagina is very dry, it is likely that the vagina is insoluble and the vagina comes back to the whole tablet. As a result, the treatment is not optimal. However, this does not cause vaginal damage. To prevent this case, it is possible to wet the vagina with a little water before being put into a very dry vagina.

Patients should use a clean towel or tape. There is no change in the color of the underwear. Patients need to be instructed to change their underwear and underwear with flanen daily and wash them at a temperature of at least 80 ° C.

Patients should not use vaginal tap or vaginal washing during Fluomizin 10 mg 1x6 treatment.

Dosage

Use 1 vagina per day, used for 6 days.

Treatment should be stopped while menstruation and then continue to return. Should be continuous treatment even when there are no more unpleasant symptoms (itching, secretion, unpleasant odor). Treatment of less than 6 days can lead to recurrence.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? On the contrary, this will increase side effects. However, no serious side effects have not been recorded after overdose of Fluomizin 10 mg 1x6.

In case of dosage, vaginal washing is needed to remove the remaining medicine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fluomizin 10 mg 1x6, you may experience unwanted effects (ADR).

Systemic disorders and medication condition.

In rare cases, there may be itching, burning or redness. However, these side effects may also be associated with the symptoms of vaginal infections. In these cases, there is no need to stop treatment. However, if the discomfort lasts, patients should come to medical facilities as soon as possible.

Local irritating reactions such as vaginal bleeding surface damage (corrosion) have been reported in individual cases (0.002%). In these cases, the vaginal surface (vaginal epithelium) was previously damaged, as as a result of an estrogen deficiency or a clear inflammatory condition. In these cases, patients have to stop treatment and should go to medical facilities.

There have been reports on fever in some very rare cases (0.0003%).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Fluomizin 10 mg 1x6 contraindicated in the following cases:

Hypersensitivity to the active ingredient or any dozen.

Vaginal epithelium and each vaginal part.

Girls who have not achieved genital maturity should not use fluomizin 10 mg 1x6.

Caution when using

Read the instructions carefully before use. If you need more information, please consult your doctor.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Fluomizin 10 mg 1x6 can be used during pregnancy. However, as well as with drugs in general, it is necessary to be cautious when prescribing Fluomizin 10 mg 1x6 for pregnant women in the first three months. Data on a small number of pregnant women in a clinical study with dequamium chlorid {55} and in a study on the use of Fluomizin 10 mg 1 x 6 {60} shows no side effects of dequamium chlorid in pregnant women or on fetal health.

Data from the survey after the drug is put into the market on a number of pregnant women (about 0.5 - 1.1 million), there is no side effects of Dequilinium Chlorid in pregnant women or on the health of the fetus and infants.

There is no animal research with dequamium chlorid. However, animal studies with quadratic ammonium compounds do not show reproductive toxicity (see the "clinical safety data" section).

Lactation period

Fluomizin 10 mg 1x6 can be used during breastfeeding.

There is no data on the reception of dequilinium chlorid into breast milk.

Based on the data on absorption and treatment time is only 6 days, the side effects on the fetus or infants are not sure.

Drug interaction

no interaction has been recorded.

Patients should notify the doctor or pharmacist if they are in use or have recently used any other drugs, even non -prescription drugs.

Cavalry: Fluomizin 10 mg 1x6 is similar to soap and other anion surfactants.

Storage

Do not store over 300C.

Other drugs

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