Flutonin 10 Hasan treats depression (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Fluoxetin

Ingredient

Composition information	Content
Fluoxetin	10mg

Uses

indications

Flutonin drugs are indicated in the following cases:

Treatment of depression disorders with different causes.

Treatment of obsession - forced disorders.

In clinical dose, fluoxetin prevents identification with seretonin but does not block norepinephrin in platelet cells.

The time is slow, until the full treatment effect usually must be from 3-5 weeks. Therefore, the case of severe depression cannot be relieved immediately after taking the drug.

Fluoxetin is the antagonist of Muscarinic receptors, histaminergic and α-1-adrenergic, have a similar relationship with anti-anti-cholinergic, sedative and cardiovascular effects like antidepressants (3 rounds) of classic. However, the cohesion of fluoxetin with these receptors and other receptors on the membrane of brain cells is inferior to 3 -round antidepressants.

Thanks to its specific effects on seretonin neurons, the side effects are common on 3 -round antidepressants (Muscarinic resistance) rarely occurs when treated with fluoxetin.

pharmacokinetic

absorption

Fluoxetin absorbs well through the gastrointestinal tract. Oral bioavailability is about 95%. Food can reduce the absorption of the drug but does not affect the bioavailability of the drug.

Distribution

The distribution volume is about 35 liters/kg. With a single dose of 40 mg/day by oral, the peak concentration of serum is from 15 - 55 mg/ml after 6 - 8 hours. The ratio of binding to protein, albumin and A-1-Glycoprotein is 94.5%.

Metabolism

Most fluoxetin converts into norfluoxetin activity and some other types of activity.

Elimination

Fluoxetin was originally converted into inactive substances in the liver, then released it through the kidney (> 90%). Fluoxetin waste time after using the only dose is about 1-3 days, but after the reminded dose, the elimination speed decreases, half a lifetime increases to about 7-15 days.

In cirrhosis patients, the half -life of fluoxetin increases from 2-3 days to 6-7 days compared to normal.

Before taking Flutonin 10 Hasan treats depression (5 blisters x 10 tablets)

How to use

Flutonin drugs are taken orally.

Take pills with water, once in the morning. If clinical signs do not progress after a few weeks of treatment, the dose may increase. If used over 20 mg/day, it should be divided into 2 times and should not be used more than 80 mg/day. Like other antidepressants, the effect of the drug is only after a few weeks (4-6 weeks) of treatment with the given dose.

Should take lower doses or interrupted for patients with liver, kidney, elderly, patients with many diseases simultaneously or treat with many different pharmaceuticals.

With acute depression, drug treatment time can last from a few months to longer. Currently, we can not know the exact dosage suitable for antidepressants used in maintenance treatment.

Dosage

Adults

Depression disorders: 20 mg/day/day, drink once in the morning. The maintenance dose is vary depending on the clinical response of each patient. Usually, after a few weeks to achieve adequate treatment effect, so do not increase the dose regularly.

Disorders of obsession - forced: Starting dose of 20 mg/day, if necessary, the dose can be increased to 60 mg/day.

Invisible diet: 60 mg/day.

Panic: Starting dose of 10 mg/day. After 1 week, the dose can be increased to 20 mg/day. The dose can be increased to 60 mg/day.

Maximum daily dose: 80 mg/day.

Children

The starting dose is usually 10 mg/day. After 1 week of use, the dose can be increased to 20 mg/day if not effective treatment. The treatment time is usually short -term (8 - 9 weeks).

Older patients

Daily dose does not exceed 60 mg/day.

Patients with mild weight, liver or kidney failure

Must reduce the dose, can be used 10 mg/time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When overdose, the symptoms are mainly nausea and vomiting. Also see symptoms of agitation, mild mania, and central nervous stimulation signs.

Treatment

Mainly treat symptoms and support. Use activated carbon and sorbitol, maintain respiration, heart activity and body temperature. If necessary, use anti -convulsions like diazepam.

Measures for hemolysis, mandatory diuretic or blood change are not effective due to large distribution volume and highly linked drugs with protein.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Flutonin, you may experience unwanted effects (ADR).

When starting treatment, restlessness, anxiety or difficulty sleeping, nausea reaction may be increased (10-20% of treatment cases). These symptoms will mostly disappear when continuing treatment.

Common

Fatigue, dizziness, sweating, impotence, unable to ejaculate, reduce sex, nausea, diarrhea, anorexia, skin rash, itching, tremor, restlessness, insomnia.

Less

headache, vomiting, digestive disorders, dry mouth, urticaria, bronchospasm/reaction like asthma, urinary retention.

Rare

fainting, serum, arrhythmia, fast vessels, vascular inflammation, peripheral reactions, movement disorders, Parkinson's syndrome, paresthesia, epilepsy, Serotonin syndrome, hyperkemin, decrease or hyperthyroidism, large breasts in men, produce lots of milk, pustules, luput erythema, hepatitis, hepatitis, lemon, lemon, sodium.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Flutonin drugs contraindicated in the following cases:

Hypersensitivity to fluoxetin or any ingredients of the drug.

severe renal failure (creatinine clearance

Patients under 18 years old.

The patient is taking Mao inhibitors (using these two drugs must be at least 5 weeks apart).

People with a history of epilepsy.

Caution when using

fluoxetin as well as other antidepressants (SSRIs) increases the risk of behaviors and thoughts that want to commit suicide in children and teenagers suffering from depression disorders and other neurological disorders.

Caution for people with a history of epilepsy due to fluoxetin can lower the threshold causing seizures. If there are seizures, immediately stop taking the drug immediately.

Be cautious when used for patients with electric convulsions during the previous 8 weeks. Be cautious when used for patients treated simultaneously with lithium, tryptophan, diabetics, heart disease and respiratory disease.

For diabetics, during treatment with fluoxetin, the phenomenon of hypoglycemia and blood sugar may increase again when stopping the drug.

The drug can cause dizziness, headache, should not stand up suddenly while in a lying or sitting position.

There are no relationships of the effect of drugs on age, including the elderly.

The ability to drive and operate machinery

any psychotropic drug, including fluoxetin, can reduce the ability to judge, think, or control behavior. Therefore, patients need to be very cautious when controlling machines, even when controlling motorcycles.

Pregnancy

Not for pregnant women.

Breastfeeding period

Do not use for breastfeeding women.

Drug interaction

Do not use drugs simultaneously with monoamin oxydase inhibitors (Mao) because it can cause confusion, agitation, consciousness, coma, digestive disorders, high fever, severe seizures or causing hypertension, vessels and fast respiratory.

Fluoxetin strongly inhibits the cytochrom P450 2D6 liver enzymes. Simultaneous treatment with metabolic drugs thanks to this enzyme and narrow treatment index such as Flecainid, Encainid, Vinblastin, Carpamazepin ... and 3 -round antidepressants must start or adjust these drugs at low doses.

The concentration of 3 -round antidepressants, Maprotlin or Trazodon in plasma can double when used simultaneously with fluoxetin, so it reduces about 50% of the dose of these drugs when used simultaneously with fluoxetin.

Concentrated with Tryptophan may appear or increase agitation, insomnia, digestive disorders.

Concentrated with drugs that act on the nervous system may increase the risk of side effects.

Linking drugs with plasma proteins (anticoagulants, digitalis or digitoxin ...) simultaneously with fluoxetin will increase the free concentration of fluoxetin in serum, increasing the risk of side effects.

Simultaneous use of Fluoxetin with Diazepam can last half -life of diazepam in some patients, but physiological and mental mental response may not be affected.

Electric shock treatment: Prolonged convulsions when treated simultaneously with fluoxetin. Phenytoin concentration may be increased when used simultaneously with fluoxetin, leading to poisoning. Should closely monitor phenytoin concentration in plasma.

using fluoxetin simultaneously with lithium may increase or decrease the level of lithium in the blood, and there have been cases of lithium poisoning occurs. Therefore, lithium concentration should be monitored.

Storage

Where dry, less than 30 ° C.

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