Fluzinstad 5 Stella medicine for preventive treatment migraine (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Flunarizine

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

Indications

Preventive treatment of migraine in case other treatments are ineffective or ineffective.

Pharmacokic

flunarizin is a drug with calcium channel blockers, antihistamines and sedatives. The drug prevents calcium overload in cells by reducing over -over -over -over calcium membrane. Flunarizin does not act on myocardial contraction, does not inhibit the atrial or atrial node, does not increase the heart frequency, does not have anti -hypertension effect.

Dynamic pharmacokinetics

absorption: Flunarizin is absorbed through the digestive tract> 80%, reaching the peak concentration of plasma within 2-4 hours after drinking and achieving a stable state at week from 5 to 6. Under the gastric gastric juice, the bioavailability of flunarizin may be lower. Large distribution volume, about 78 liters/kg in healthy people and about 270 liters/kg in epilepsy patients, with high distribution levels outside the circuit. The drug quickly passed through the blood -brain barrier, the concentration of the brain in the brain is about 10 times higher than the plasma concentration. The main metabolic line is through CYP2D6. After taking 24 - 48 hours, about 3-5% of the dose is eliminated in the form of stool in the form of original drugs and metabolites, and 0.5 nanogam/ml) for a long time (up to 30 days), which may be due to the release of drugs from other tissues.

Before taking Fluzinstad 5 Stella medicine for preventive treatment migraine (10 blisters x 10 tablets)

How to use

Adults under 65 years old and elderly (over 65 years old)

5mg/day, drink in the evening, maintain for 4 to 8 weeks. 6 months.

Children over 12 years of age, especially in the case of unexplained migraine: 5mg/day, drink in the evening. Treatment time does not exceed 6 months. It is not recommended to use flunarizin for children under 12 years old.

Dosage in patients with liver failure

Because the drug is metabolized with a large level of the liver, the dosage should be adjusted in these patients. Starting dose: 5mg/day, taken in the evening.

Dosage

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? A few cases of an overdose (high dose to 600mg oral 1 time) have been reported, the observed symptoms are drowsiness, excitement and tachycardia. Acute overdose treatment includes active carbon, vomiting or stomach rinse and supportive measures.

Side Effects

Common ADR> 1/100

Central nervous system: Dreaming, fatigue.

Central nervous system: Symptoms of extracurricular tower (slow movement, stiffness, restless sitting, dysplasia, tremor), depression.

Digestive: Nausea, stomach pain

Central nervous system: Anxiety.

Skin: rash.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Hypersensitivity to flunarizin or any excipients of the drug.

Be cautious when using

Do not use the recommended overdose. It is necessary to monitor patients regularly, periodically, especially during the maintenance treatment period to early detect expressions of extracurricular, depression and stop treatment promptly. If this condition occurs, it is necessary to stop treating with flunarizin. Patients with rare genetic galactose intolerance, Lapp Lactase deficiency or poorly absorbent glucose - Galactose does not use this preparation.

The effect of the drug on the ability to drive and operate machinery

due to sleepiness may occur, especially at the beginning of treatment, so be cautious in activities such as driving or operating dangerous machines.

Using drugs for women during pregnancy and lactation

There is no safe data of flunarizin in pregnant women. Animal studies do not prove the direct or indirect effects on the pregnancy, development of embryos/fetuses, birth and development of children.

Interactive drug

Hepatic enzyme -causing drugs such as carbamazepin, phenytoin and valproat can interact with flunarizin due to increased flunarizin metabolism in the liver, need to increase the dose of flunarizin when used with these drugs. level.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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