Fluzinstad Stella medicine for preventive treatment migraine (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Flunarizine

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

Indications

Preventive treatment for migraine in case other treatments are not effective or less tolerant. The drug prevents calcium overload in cells by reducing over -over -over -over calcium membrane. Flunarizin does not act on myocardial contraction, does not inhibit the atrial or atrial node, does not increase the heart frequency, does not have anti -hypertension effect.

pharmacokinetic

absorption

Flunarizin is absorbed through the gastrointestinal tract> 80%, reaching a plasma peak concentration within 2-4 hours after drinking and achieving a stable state at a week from 5 to 6. In the condition of the gastric gastric acid, the bioavailability of Flunarizin may be lower.

Distribution

flunarizin is connected to plasma proteins> 99%. Large distribution volume, about 78 liters/kg in healthy people and about 270 liters/kg in epilepsy patients, with high distribution levels outside the circuit. The drug quickly passed through the blood -brain barrier, the concentration of the brain in the brain is about 10 times higher than the plasma concentration.

Metabolism

flunarizin is converted through the liver into at least 15 metabolites. The main metabolic line is through CYP2D6.

Elimination

flunarizin is excreted mainly through biliary feces in the form of original drugs and metabolites. After taking 24 - 48 hours, about 3-5% of the dose is eliminated in the form of stool in the form of original drugs and metabolites, and 0.5 nanogam/ml) for a long time (up to 30 days), which may be due to the release of drugs from other tissues.

Before taking Fluzinstad Stella medicine for preventive treatment migraine (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults under 65 and the elderly (over 65 years old):

5mg/day, drink in the evening, maintain for 4 to 8 weeks.

During treatment, if the symptoms of depression, foreign tower or other serious adverse events appear, it is necessary to stop taking the drug.

If after 8 weeks of treatment there is no improvement, the patient is considered to not respond to treatment and should stop taking the drug.

Treatment time must not exceed 6 months.

Recommended for patients under 65 years of age: If the patient's clinical manifestation shows that the response is incomplete, may increase the dose up to 10mg/day but need to consider in the patient's tolerance ability.

Children:

Children over 12 years old, especially in the case of unexplained migraine: 5mg/day, drink in the evening. Treatment period must not exceed 6 months.

Children under 12 years of age: There is no full evidence of the effect and safety of flunarizin on this object. It is not recommended to use flunarizin for children under 12 years old.

Dosage in patients with liver failure:

Because the drug is metabolized with a large level of the liver, the dosage should be adjusted in these patients. Starting dose: 5mg/day, taken in the evening.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In some cases of acute overdose (high doses to 600mg oral 1 time) have been reported, the observed symptoms are drowsiness, excitement and fast heart rate.

Management: There is no specific antidote. Acute overdose treatment includes active carbon, vomiting or stomach rinse and supportive measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Central nerve: Drowsy, tired.

digestion: Increase appetite, weight gain.

Uncommon, 1/1000

Central nervous system: Symptoms of foreign tower (slow movement, stiffness, restless sitting, dysplasia, tremor), depression.

digestive: dry mouth.

Rare, ADR

Digestive: Nausea, stomach pain.

Other: Increasing lactation.

Not determined frequency

Central nervous system: Anxiety.

DA: rash.

Muscle muscle: muscle pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Fluzinstad drugs are contraindicated in the following cases:

Hypersensitivity to flunarizin or any excipients of the drug.

Symptoms of Parkinson's disease before treatment.

History of foreign symptoms.

depression or a history of recurrent depression syndrome.

Precautions when using

Do not use the recommended overdose. It is necessary to monitor patients regularly, periodically, especially during the maintenance treatment period to detect early expressions of extracurricular, depression and stop treatment promptly.

Some rare cases of increasing severity have been recorded when using flunarizin. If this condition occurs, it is necessary to stop treating with flunarizin.

If the treatment is not effective, stop taking the drug.

If the dose is higher than the recommended dose can cause accumulation, with an increase in unwanted effects.

Fluzinstad contains lactose. Patients with rare genetic galactose intolerance, Lapp Lactase deficiency or malposure of Glucose - Galactose do not use this product.

The ability to drive and operate machinery

Due to sleepiness, especially at the beginning of treatment, it should be cautious in activities such as driving or operating dangerous machines.

Pregnancy

There is no safe data of flunarizin in pregnant women. Animal studies do not prove the direct or indirect effects on the pregnancy, development of embryos/fetuses, birth and development of children.

Breastfeeding period

No report.

Medicinal interaction

Liver enzyme -induced drugs such as carbamazepin, phenytoin and valproat can interact with flunarizin due to increased flunarizin metabolism in the liver, need to increase the dose of flunarizin when used with these drugs.

When using flunarizin with alcohol, sedative or sleeping pills can cause excessive sedation.

Causes the syndrome of milk secretion in several women taking birth control pills within the first two months of treatment with flunarizin.

Flunarizin is not contraindicated in patients who are taking drugs for hypertension in the beta blocker but need to adjust the dose.

Storage

Temperature does not exceed 30 ° C.

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