Fonotim treatment for chronic osteoarthritis, rheumatoid arthritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Nabumetone

Ingredient

Composition information	Content
Nabumetone	500mg

Uses

indications

Fonotim 10x10 Daehan is indicated in the following cases:

Treatment of acute and chronic symptoms of chronic osteoarthritis and rheumatoid arthritis (inflammation, swelling, stiffness and joint pain). The drug has the ability to inhibit prostaglandin biosynthesis, which is intermediate inflammation. Nabumeton is a precursor, after being oxidized in the liver to form 6-methoxy-2-naphthylacetic acid (6MNA) is active thanks to the similar structure of Naproxen with the ability to inhibit the synthesis of Prostaglandin.

Pharmacokinetics

absorption

Used with food will increase the absorption rate and the appearance of 6MNA in plasma but does not affect the convert natumeton to 6mna. The peak concentration of 6mna in plasma increased by about 1/3. Used with aluminum -free antacids does not significantly affect the bioavailability of 6mna. 6MNA is metabolized through the liver to form non -active chemicals and are eliminated in two forms of free and combined form.

Distribution

6MNA is connected to plasma proteins about 99%.

Metabolism

Natumeton is not found in plasma, after being absorbed, Natumeton is oxidized in the liver to form a major activity metabolism, 6-methoxy-2-naphthylacetic acid (6mna). After taking a dose of 1000 mg, about 35% is converted into 6mna and 50% converted into unknown substances and they are eliminated in urine.

Elimination

After drinking, about 80% of the dose of Natumeton marks found in the urine. About 75% of the marked dose is found in urine after 48 hours. After taking the dose of 1000 mg 2000 mg, the average plasma clearance is 20 - 30 ml/min and the sale time is about 24 hours.

Before taking Fonotim treatment for chronic osteoarthritis, rheumatoid arthritis (10 blisters x 10 tablets)

How to use

Take oral use in the evening before going to bed.

Dosage

Adults

The starting dose is usually 2 tablets (1 g), drink once a day. Some patients may need a dose of up to 1.5 or 2 g/day to reduce symptoms. The dose may be adjusted depending on the patient.

Maintenance dose 1 - 2 g, no more than 2 g/day, drink once or divide into 2 times/day.

Patients weighing less than 50 kg: Do not use more than 1 g/day.

Elderly

Like other drugs, Natumeton concentration is usually higher than in the blood of the elderly.

The recommendation daily does not exceed 1 g, in most cases, the dose of 1 tablet (500 mg/day) has shown a good response in these objects.

Patients with renal failure

No dose adjustments in patients with renal failure have clearance> 50 ml/min.

For patients with clearance from 30 to 49 ml/min, the dose should be reduced, the starting dose is 750 mg/day, which can increase to a maximum of 1.5 g/day.

Patients with clearance

Children

Safety and efficiency in children have not been established.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Dear, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding can occur, hypertension, acute kidney failure, depression and coma may occur.

Management:

Patients need to be taken care of and treated symptoms. There is no specific antidote. Can cause vomiting or activated carbon drink (60 - 100 g in adults, 1 - 2 g/kg in children).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Fonotim 10x10 Daehan you may experience unwanted effects (ADR).

Uncommon, 1/1000

Digestive system: indigestion, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea, belching, esophagitis, peptic ulcer, potential or massive gastrointestinal bleeding.

Hematology: Anemia, blood formula disorders (leukocytes), leukopenia, thrombocytopenia.

Skin: stomatitis, itching, rash, urticaria.

Respiratory: may initiate acute asthma attacks.

Central nervous system: headache, dizziness, tinnitus, dozing, fatigue. Cardiovascular: edema, hypertension, lower limb, tachycardia, blushing. liver: temporarily increased serum transaminase or bilirubin. kidney: Disorders of kidney function parameters (increased serum creatinine or urea in urine). vision: conjunctivitis, visual disorders.

Rare, ADR

Digestive system: gastric perforation, rectal inflammation, gastritis.

liver: hepatitis. allergies: edema, increased sensitivity reaction include: anaphylactic reaction. cardiovascular: thrombosis.

Skin: Sensitive to light, erythema, diverse, blistering such as Stevens Johnson syndrome, epidermal necrotic poisoning. kidney: renal failure.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Fonotim 10x10 daehan contraindicated in the following cases:

Patients with a history of sensitivity to Nabureton or any ingredient of the drug.

Patients with aspirin and other nonsteroidal anti -inflammatory drugs: Patients with signs of asthma, nasal polip, angioedema or urticaria after taking aspirin and other nonsteroidal anti -inflammatory drugs.

Progressive peptic ulcer patient.

Patients with severe liver failure.

Patients with severe renal impairment are not allowed to climb.

Children under 15 years old.

Pregnant and lactating women.

Be cautious when using

be careful when taking this medication in patients with gastrointestinal pathology or being treated with anti -dynamic drugs.

Need to monitor the abnormal manifestations in the stomach - intestines. The drug should be stopped if signs of ulcer or gastrointestinal bleeding.

As most of other nonsteroidal anti -inflammatory drugs, sometimes the drugs increase serum transaminase or other liver function indicators. In patients with signs of impaired liver function or abnormal liver tests, it is necessary to determine the progression and severity of the liver function during the medication period. There have been some serious reactions on the liver such as jaundice, hepatitis when using nonsteroidal anti -inflammatory drugs. Although very rare, if the abnormalities in the testing of liver function are not lost and become worse or the appearance of whole body (eosinophilia, eosin, rash ...), stop using nabometon. Because Nabometon's biological transformation into 6mna is dependent on liver function, the biological change can be reduced in patients with severe liver failure. Therefore, it is necessary to be cautious when using nabuleton for patients with severe liver failure.

The combination treatment of anti -inflammatory drugs and painkillers only treat symptoms, not treatment.

When taking this medication to treat chronic symptoms, it is important to note the following factors: When taking the drug for a long time, regular tests should be checked (liver function test, blood count ...). If there are abnormal signs, appropriate handling measures such as: reducing the dose or stopping drugs.

When treating acute symptoms, note the following points:

It is necessary to consider carefully in the case of acute inflammation, pain and fever.

It is necessary to treat the cause if possible.

Non -steroid anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatorys in the kidneys play a role in supporting kidney perfusion. Keeping water and causing edema is reported in some patients using nabometon. Therefore, like other nonsteroidal anti -inflammatory drugs, need to be cautious when taking drugs in patients with congested heart failure, high blood pressure.

Risk of cardiovascular thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recognized.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, the drug is required at the lowest daily doses to be effective in the shortest possible time.

The ability to drive and operate machinery

Sometimes nabometon causes headaches, dizziness, tinnitus, falling asleep, fatigue, need to be cautious when using the drug for people who have to drive or operate machinery.

Pregnancy

Do not take medicine for pregnant women.

Breastfeeding period

Do not take medicine for nursing women.

Drug interaction

In clinical trials, the metabolic substance of nabuleton is 6MNA strongly associated with protein, so it is likely that other drugs at the position of protein mounted. Be careful when using nabuleton with wafarin because it has recorded interactions between wafarin and other nonsteroidal anti -inflammatory drugs. Naabometon sharing with aluminum antacid drugs does not affect the bioavailability of 6mna. When used with food or milk, nabuleton absorbs faster but the total amount of 6mna in the blood does not change.

Storage

Store in closed packaging, avoid light, at temperatures below 30 ° C.

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