Forair 250 Inhaler Cadila Spray for chronic asthma treatment (120 doses)

Dosage form Box
Specifications Salmeterol, Fluticasone Furoate

Ingredient

Composition informationContent
Salmeterol25mcg
Fluticasone Furoate250mcg

Uses

indications

Forair 250 inhaler is indicated in the following cases:

  • Chronic asthma treatment including children and adults, when combined treatment (bronchodilators and spray corticosteroids) are appropriate.

    Salmeterol is a beta-2 sympathetic receptor owner who has a long and high choice effect with a long string that connects to the exiper (EXO-Site) of the receptor. Salmeterol produces bronchodilator effects.

    fluticasone propionate:

    At the recommended dose, a dose of Fluticasone Propionate sprayed containing strong anti -inflammatory glucocorticoid activity in the lungs, reducing symptoms and drama of asthma, and fewer side effects when using corticosteroids.

    pharmacokinetics

    salmeterol:

    Only act at the lungs, so the plasma concentration does not indicate the impact in treatment. The drug is in the form of aerosol, bronchodilator appears after 2-3 minutes, up to 5 to 15 minutes and lasts 3-4 hours. Low plasma concentration (treatment dose is approximately 200 PG/ml or less), reaching a maximum within 2-4 hours.

    about 72% of the inhaled pills excreted in the urine within 24 hours, of which 28% did not change and 44% have metabolized. Half -life elimination of the drug is 3.8 hours. Due to the low plasma concentration, the aerosol is less likely to cause side effects than the tablet or injecting. Therefore, the aerosol type can be used in patients with hyperthyroidism, arrhythmia, coronary circulation disorders, hypertension, diabetes, patients are taking Monoamin oxydase inhibitors.

    Fluticasone Propionate regular spray in healthy people is about 10%. The rest of the spray can be swallowed but it affects the whole body very little due to the ability to dissolve into low fluid and metabolism before absorption, resulting in oral use about 1%.

    fluticasone propionate:

    The properties of fluticasone propionate are expressed by high plasma clearance (1150 ml/min), wide distribution integral (about 300L) and half -life semi -waste approximately 8 hours. Protein cohesion is 91%. Fluticason is quickly excreted from the circulatory system, and is converted mainly into carboxylic acid that is no longer active by Cytochrome P450 enzyme CYP3A4.

    The renal clearance for Fluticasone Propionate is negligible. Nearly 5% of the dose is eliminated through the kidneys mainly in the form of metabolism. Should be cautious when using embryos suitable for CYP3A4 inhibitors already know because there is a risk of increasing the level of fluticasone propionate.

    • Before taking Forair 250 Inhaler Cadila Spray for chronic asthma treatment (120 doses)

    How to use

    erect the spray with the index and thumb, shake well. Breathe out and let the mouth spray into the mouth, between the two teeth.

    Suck the spray with lips, do not bite. Slightly tilted your head back, inhaled slowly and pressed a dose while continuing to inhale evenly and deep.

    Remove the spray bottle, keep the breath for at least 10 seconds or until it is comfortable. Then exhale slowly.

    Dosage

    for chronic asthma and chronic obstructive pulmonary disease.

    Patients must be notified as regular medication even without symptoms. Patients need to be examined regularly by the doctor to be optimal drug content.

    adults and children over 12 years old:

    Spray 2 times/day.

    Salmeterol dose 25 µg + fluticasone propionate 125 µg is not for children under 12 years old.

    Special patients:

    Do not adjust the dose for the elderly or patients with renal failure.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when overdose? In this case, the selected beta sympathetic blockers on the heart and should be cautious when taking these drugs for patients with a history of bronchospasm.

    Fluticasone propionate overdose can lead to temporary inhibition of hill - pituitary - adrenal glands, but this situation will pass after a few days.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

    Side Effects

    When using Forair 250 Inhaler, you may experience unwanted effects (ADR).

    Not determined frequency:

    salmeterol:

  • The pharmacological side effects of the Beta drug owner such as tremor, brushing chest and headache, have been reported, but these reactions are often transient and decreased when the drug has been used regularly.

    • Arrhythmic (including atrial fibrillation, ventricular tachycardia and non -mind -collection) can occur often in sensitive patients.

  • There are reports on symptoms of joint pain and hypersensitivity reactions, including rash, edema and angioedema, rarely muscle pain.

    • fluticasone propionate:

  • Hypersensitivity reaction has been reported.
  • hoarseness and cantida and throat fungus can occur in some patients. Both hoarse symptoms and frequency of candidiasis can be reduced by rinse with water after using salmeterol and fluticasone propionate. Symptoms of candidiasis can be treated with antifungal drugs while continuing to use salmeterol and fluticasone propionate.

    • At the clinical trials on salmeterol and fluticasone propionate, unwanted reactions are often reported: hoarseness/hard -to -speak, throat irritation, headache, mouth and throat Candida and chest drum.

    Instructions on how to handle ADR

    Please notify the doctor the adverse effects encountered during the use of the drug.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Forair 250 inhaler contraindicated in the following cases:

    Patients with a history of hypersensitivity to any ingredients of the drug.

    Caution when using

    must not stop suddenly during treatment with Forair.

    Forair is not a medication for acute asthma symptoms. As with other corticosteroids, Forair should be used carefully in progressive tuberculosis patients or potential tuberculosis.

    Similar to other inhaled treatment therapies, naughty bronchospasms may occur often with increased wheezing symptoms immediately after taking the drug. Should treat instantaneously with a quick inhaled bronchodilator. Salmeterol and Fluticasone Propionate should be stopped, patients need to be examined and used for other replacement treatments if necessary.

    If signs of hypothalamus - pituitary - adrenal glands such as hypotension, nausea, vomiting, dizziness or weakness, should stop the drug or reduce the number of use.

    The ability to drive and operate machinery

    no effect.

    Pregnancy

    Consider the risk and benefits for the fetus before taking Forair for pregnant women.

    The period of breastfeeding

    still does not know if the drug is secreted into breast milk, but both Salmeterol and Fluticasone Propionate are secreted into mouse milk. Therefore, it is also necessary to consider risks and benefits for young children before taking Forair for breastfeeding women.

    Interactive drug

    should avoid using selective and non -selective beta receptor blockers in patients with airway obstruction disease that can recover, unless there are required reasons.

    Although the forair concentration in plasma is very low, it is not used with strong Cytochrome P450 3A4 (Ritonavir) inhibitors, which can cause corticosteroid side effects including cushing syndrome and adrenal inhibitors.

    Simultaneous use of Salmeterol and Ketoconazole significantly increases salmeterol levels in plasma (CMAX increases by 1.4 times and AUC increases 15 times).

    Storage

    Keep the drug below 30 ° C. Do not be frozen.

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