Franmoxy 500 eloge treat sinusitis, otitis media, tonsillitis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amoxicillin

Ingredient

Composition information	Content
Amoxicillin	500mg

Uses

indications

Franmoxy 500 drug is indicated for treatment of sensitive bacteria in both adults and children:

Acute sinusitis.

Acute otitis media. Thanh.

Acute pyelonephritis. Power

Pharmacological group: Penicilin antibiotics. ATC code: J01CA04.

Mechanism of action: Amoxicillin is a semi -synthetic penicillin (beta - lactam antibiotic), which has a bactericidal effect attached to one or more enzymes (penicillin -mounted proteins) of bacteria, leading to inhibition of peptidoglycan biosynthesis, an important structural component of bacterial cell wall walls

Amoxicillin does not work on Beta-Lactamase anti-bacteria.

The relationship between pharmacokinetics and pharmacokinese:

The time for antibiotic concentration is higher than the minimum inhibitory concentration (T> MIC) is the main factor that determines the validity of Amoxicillin.

Anti -drug mechanism: Amoxicillin resistance mechanisms include:

antibiotic activity by beta - lactamase of bacteria. Application:

Amoxicillin has the effect of printing Vitro on the following bacteria:

Gram -positive aerobic energetic Enterococcus Faecalis, Streptococci Beta Beta (Group A, B, C, G), Listeria Monocytogenes.

Gram -positive aerobic: Staphylococcus coagulase is negative, Staphylococcus aureus (almost all S. Aureus resistance amoxicilin due to penicillinase, all methicillin -resistant strains are amoxicillin resistant), Streptococcus pneumoniae, streptococcus Viridans. Gram negative gas: Fusobacterium spp.

Other strains: Borrelia Burgdorferi.

Gram -positive aerobic: Enterococcus Faecium. Mycoplasma spp., Legionella spp. Oral bioavailability is about 70%. Time to reach peak concentration in plasma is about 1 hour. Within the dose by food from 250 - 3000 mg, bioavailability increases linear with the dose. Absorption is not affected by food.

About 18% amoxicillin binds to plasma proteins. After intravenous injection, amoxicillin is distributed in gallbladder, abdominal tissue, skin, muscle, fat tissue, epidemic, abdominal fluid, molasses and pus.

Amoxicillin does not enter the cerebrospinal fluid. Drugs through placenta and distribution in breast milk.

About 10 - 25% amoxicillin converts into penicilloic acid without activity.

Amoxicillin is excreted mainly through the kidneys. The sale time is about 1 hour, the clearance is about 25 liters/hour in normal people. About 60 - 70% amoxicillin excreted the kidneys in the form of unchanged in the first 6 hours after taking single dose 250 mg, 500 mg. Amoxicillin eliminates the kidneys 50 - 85% within 24 hours. Probenecid slowed down amoxicillin. Amoxicillin may be removed when hemolysis.

Age: Amoxicillin's waste time in children over 3 months old and adults are similar. In newborns (including premature babies), in the first week, it is not advisable to take more than 2 times/day due to the incomplete renal excretion.

Sex: Gender does not affect the pharmacokinetics of amoxicillin when used orally.

Renal failure: Amoxicillin's clearance decreases proportional to renal function. Need to adjust the dose for patients with kidney failure.

Liver failure: Amoxicillin should be used carefully for people with liver failure and should check liver function regularly.

Before taking Franmoxy 500 eloge treat sinusitis, otitis media, tonsillitis (10 blisters x 10 tablets)

How to use

Franmoxy 500 medicine for oral. Take tablets with water.

Dosage

Dosage of the drug depends on the level of sensitivity of pathogenic bacteria, the degree and site of infection, age, weight and kidney function of the patient. Treatment time depends on the type of infection and response of the patient.

Dosage for adults and children over 40 kg:

Acute sinusitis, asymptomatic urinary infection during pregnancy, acute pyelonephritis, tooth abscess accompanied by spreading cellulitis, acute cystitis: 250 - 500 mg, 8 hours/time; or 750 mg - 1 g, 12 hours/time.

Severe infections: 750 mg - 1 g, 8 hours/time.

Acute cystitis: The dose of 3 g x 2 times/day can be used for 1 day.

Acute otitis media, tonsillitis and acute sore throat due to sreptococcus, acute period of chronic bronchitis: 500 mg, 8 hours/time; or 750 mg - 1 g, 12 hours/time.

Severe infections: 750 mg - 1 g, 8 hours/time, 10 days.

Pneumonia has a community: 500 mg - 1 g, every 8 hours.

Typhoid and deputy typhoid: 500 mg - 2 g, 8 hours/time.

Fake joint infections: 500 mg - 1 g, 8 hours/time.

Preventive infection in the heart: The only dose of 2 g, drink before doing the procedure 30 - 60 minutes.

Helicobacter pylori infection: 750 mg - 1 g x 2 times/day, in combination with Proton inhibitors (Omeprazole, Lansoprazole) and other antibiotics (Clarithromycin, Metronidazole), used for 7 days.

Lyme disease:

Early period: 500 mg - 1 g, 8 hours/time, maximum dose 4 g/day, used for 14 days (10 - 21 days).

The final period: 500 mg - 2 g, 8 hours/time, a maximum dose of 6 g/day, used for 10 - 30 days.

Dosage for children under 40 kg:

Acute sinusitis, acute otitis media, community -suffering pneumonia, acute cystitis, acute pyelonephritis, tooth abscess accompanied by spreading cellar inflammation: 20 - 90 mg/kg/day, divided 2-3 times.

Tonsillitis and acute pharyngitis due to sreptococcus: 40 - 90 mg/kg/day, divided 2-3 times.

Typhoid and deputy typhoid: 100 mg/kg/day, divided 3 times.

Preventive infection in the heart: 50 mg/kg, take the only dose before doing the procedure 30 - 60 minutes.

Lyme disease:

In the early period: 25 - 50 mg/kg/day, divided 3 times, used for 10 - 21 days. Specifications of the Spiritual Filter (ml/minute) Adults and children ≥ 40kg 40 kg 30 Maximum of 500mg x 2 times/day 15 mg/kg x 2 times/day (maximum 500mg x 2 times/day) Used for patients with hemolysis:

Adults and children over 40 kg: Single dose 15 mg/kg/day. Take additional doses of 15 mg/kg before the fertilization. To restore the concentration of drugs in the blood, use an additional dose of 15 mg/kg after the fertilization.

Dosage for peritoneal fertilizer: up to 500 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The urinary crystal leads to renal failure. Convulsions can occur in patients with renal failure or high doses.

Treatment: Treatment of symptoms, pay attention to water - electrolyte balance. Amoxicillin can be removed by hemolysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Common: diarrhea, nausea; DA.

Less: vomiting; Urticaria, itching.

Very rare: mucosal candidiasis; Reducing leukocytes (including grain leukemia), platelets with recovery, hemolytic anemia; prolong bleeding time and prothrombin time; serious allergic reactions, including nerveema, anaphylactic shock, serum disease, hypersensitivity vascular disease; increase movement, dizziness, convulsions; Colitis (including fake colitis, hemorrhage colitis, black hair growth; hepatitis, jaundice, cholestasis, AST liver enzymes, ALT; Skin reactions such as diverse roses, Stevens - Johnson syndrome, poisoned epidermal necrosis, puffiness, flaking dermatitis, external pustular syndrome (AEGP); interstitial kidney inflammation.

Also may encounter Jarisch - Herxheimer reaction.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Franmoxy drug contraindicated in the following cases:

Hypersensitivity to amoxicillin, penicillin group antibiotics or any ingredients of the drug.

Be cautious when used

Before treating with amoxicillin, it is necessary to find out the history of hypersensitivity reactions to penicillin, cephalosporin or other beta -lactam antibiotics. If allergic reactions occur, the medication should be stopped and treated with other appropriate drugs.

Be cautious, only use drugs when identifying bacteria that cause amoxicillin sensitivity, especially when treating urinary tract infections and severe ear, nose and throat infections.

There may be seizures in patients with impaired renal function, high doses or a history of convulsions, epilepsy, meningitis. Need to adjust the dose according to the degree of renal failure.

There may be skin reactions such as pustules, erythema with fever. It may be a symptom of the acute all -body pustules syndrome (AEGP). Avoid using amoxicilin for patients with monon cellular hypernagus, due to the risk of rash.

There may be a Jarisch-HERXHEIMER reaction when treating Lyme.

Long -term use can cause excessive growth of non -sensitive bacteria. Colitis associated with antibiotics has been reported. Attention should be paid to diagnosing this disease in patients with diarrhea during or after antibiotics.

There has been a report on liver enzyme hyper enzyme and changing blood formula. Should periodically assess liver, kidney and hematopathy when long -term treatment.

Rarely cases prolong prothrombin when treated with amoxicillin. The dose of oral anticoagulant may be required when used at the same time.

In patients, the urine is reduced, may be crystal. When using high -dose amoxicilin, adequate water supplements. In patients with bladder pipes, pipeline should be regularly checked regularly.

may have a false positive reaction when performing tests by chemical methods. When testing the urinary glucose, the enzyme should be used. Amoxicillin may falsify the quantitative results of estriol in pregnant women.

The effect of the drug on driving and operating machinery

may occur unwanted effects such as allergic reactions, dizziness, convulsions that affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women: Animal research does not see the harmful effects of amoxicilin to reproduction. The limited data on the use of amoxicillin during human pregnancy also does not indicate the risk of birth defects. Amoxicillin can be used for pregnant women when benefits are higher than risk.

breastfeeding women: amoxicillin excretion a small amount of breast milk, which can cause diarrhea, mucous mucous infections in breastfed babies. Only use drugs for women who are breastfeeding after evaluating benefits and risks.

Drug interaction

Probenecid reduces amoxicillin excretion leading to an increase in drug concentration in plasma.

Simultaneous use of amoxicilin with allopurinol may increase the ability to cause allergic reactions on the skin.

Tetracyclin and other bactericidal medications may affect the bactericidal ability of amoxicillin.

There have been cases of increasing international normalization index (INR) in patients treated with amoxicillin simultaneously with acenocoumarol or warfarin. Prothrombin or INR is required, may need to adjust the anticoagulant dose.

Penicilin can reduce excretion leading to increased toxicity of methotrexate.

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