Fugacar 500mg Janssen medicine for worm infection (1 tablet)

Dosage form Tablet
Specifications Box of 1 blister x 1 tablet
Ingredient Mebendazole

Ingredient

Composition information	Content
Mebendazole	500mg

Uses

indications

Fugacar 500 drug is indicated in the following cases:

To treat one or more types of worms in the intestinal tract, including trichuris trichuria, needle worm (enterobius vermicularis), roundworm (Ascaris lumbricoides), hookworms (Ancylostoma duodenale, Necator Americanus).

There is no evidence that Fugacar tablets are effective in the treatment of tapeworm larvae.

Pharmacology

Medicine group treatment: Oral helminth pesticides, Benzimidazole derivatives.

ATC code: P02CA01.

In vitro and in vivo research shows that Mebendazole inhibits selective and irreplaceable glucose absorption in adult worms and worm larvae. The inhibition of glucose absorption seems to lead to exhaustion of endogenous glycogen reserves in worms. Lack of glycogen leads to reduced ATP formation and super structural changes in the cell. There is no evidence that Fugacar is effective in the treatment of tapeworm larvae.

Dynamic pharmacokinetics

absorption

After oral use,

distribution

Mebendazole's cohesion of plasma proteins is about 90 to 95%. The distribution of 1 to 2 l/kg shows that Mebendazole may penetrate the non -circuit organization. This is shown by the data about tissue concentration in patients with chronic treatment with Mebendazole (for example, a dose of 40 mg/kg/day for 3-11 months).

transformation

Mebendazole is used by the oral that is metabolized strongly through the liver. The plasma concentration of the main metabolites (hydrolysis and reducing form of Mebendazole) is significantly higher than that of Mebendazole. A decline in liver function, metabolism, or excretion through biliary tract can lead to higher plasma mebendazole levels.

Elimination

Mebendazole, Mebendazole combinations and its metabolites can undergo many rounds of intestinal circulation and are eliminated through urine and bile. The apparent sale time after a dose of drinking about 3 to 6 hours in most patients.

pharmacokinetics in a stable state

Mebendazole concentration and main metabolites in plasma increases when used for a long time (e.g. 40 mg/kg/day for 3-11 months), leading to concentration at a stable state 3 times higher than using a single dose.

Before taking Fugacar 500mg Janssen medicine for worm infection (1 tablet)

How to use

oral tablets.

Dosage

Adults and children over 2 years:

1 single fugacar 500 mg.

Tablets can be chewed or swallowed. Crush the tablet before using for children. Always supervise children when children are taking this medication.

Should consider using fugacar in the form of oral fluid for patients such as children can not swallow the whole pill.

Children under 2 years old:

See the cautious part when used.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Except for the case of grain leukemia and glomerulonephritis, these adverse reactions are also reported in patients treated with the standard dose of Mebendazole.

signs and symptoms

In accidentally taking overdose, abdominal spasms, nausea, vomiting and diarrhea may be encountered.

Treatment

There is no specific antidote. Can use activated carbon if appropriate.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Fugacar 500 you can experience unwanted effects (ADR).

During this section, the harmful reaction is reported. The adverse reaction is that the harmful events are considered to be relevant to the use of Fugacar based on comprehensive evaluation of existing information information. The causal relationship with Fugacar cannot be reliable in individual cases. Moreover, because clinical trials are conducted under various conditions, the frequency of adverse reactions observed in clinical trials of a drug cannot be directly compared to the frequency of clinical trials of another drug and may not reflect the frequency of observation in clinical practice.

The safety of Fugacar has been evaluated on 6276 subjects participating in 39 clinical trials to treat an infection of one type or many digestive parasites. In 39 clinical trials, there is no adverse reaction of any drug (ADR) that occurs at ≥ 1% of the subject of Fugacar.

ADRs are determined from clinical trials and post -circulating experiences with Fugacar are included in Table 1. The types of frequency are presented in accordance with the following convention:

Very common (≥ 1/10);

Common (≥ 1/100 to

Uncommon (≥ 1/1000 to

rare (≥ 1/10,000 to Classification of agencies

Agricultural reaction 1/100) Rare (≥ 1/10,000 to

Loss of leukemia *

The immune system disorders

Dizziness

digestive disorders abdominal pain uncomfortable in the abdominal area; Diarrhea; Full of hua, nausea, vam Abnormal liver function test

Poisoned epidermal necrosis

Stevant-Johnsonb syndrome

Banb

Tharma

urticaria

Hair loss

kidney and urinary disorders

B ADR is not observed in clinical trials and frequency is based on 6276 patients in clinical and epidemiological research, divided by 3 (frequency = 1/2092).

* Observe for higher doses and longer use time.

Report on suspicious adverse reactions

Reporting suspicious adverse reactions after granting product circulation is very important. It allows to continue monitoring the benefits/risks of the product. Health staff are required to report any suspicious adverse reactions through the national reporting system.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Fugacar medicine 500 Contraindicated in the following cases:

Contraindicated using Fugacar for children under 1 year of age in the treatment of a series of cases of one or more intestinal worms. In addition, contraindicated use of fugacar during pregnancy and in patients with hypersensitivity to the drug or any ingredient of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

The post -circulating experience with Fugacar, which has recorded seizures in children, including children under 1 year of age with very rare frequency.

Fugacar has not been widely studied in children under 2 years old. Therefore, Fugacar should only be used for children from 1-2 years if the benefits are greater than the potential risk (for example, if the child's worm infection is significantly affected by the child's nutrition and physical development).

Hiếm gặp báo cáo về rối loạn chức năng gan có hồi phục, viêm gan, và giảm bạch cầu trung tính ở những bệnh nhân được điều trị với mebendazole liều chuẩn trong các bệnh lý được chỉ định. These events, along with glomerulonephritis and loss of granulocytes, are also reported when using the dose higher than the recommended and treated dose levels in a long time.

Results from a case-Control Study study on the appearance of Stevens-Johnson syndrome/poisoned epidermal necrosis (SJS/Ten) suggesting the possibility of SJS/Ten and simultaneous use of Mendazole and Metronidazole. There is no additional data on drug -drug interaction.

Therefore, it is advisable to avoid using Mebendazole and Metronidazole simultaneously.

Mebendazol tablets contain lactose. Patients with rare genetic problems galactose, Lactase deficiency or glucose-Galactose should not take this drug.

The effect of the drug on driving and operating machinery

Fugacar 500 does not affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnancy

Because Fugacar is contraindicated during pregnancy, patients think that they are or may be pregnant should not use this preparation.

Breastfeeding period

Restricted data from reports shows a small amount of Mebendazole appearing in breast milk after taking the medication. Therefore, be careful when using Fugacar for breastfeeding women.

Drug interaction

simultaneously used with cimetidine can inhibit the metabolism of Mebendazole in the liver, the result increases the concentration of drugs in plasma.

Should avoid simultaneous use of mebendazole with metronidazole.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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