Furosemide injection solution 20mg Vidipha treat acute pulmonary edema, heart, liver, kidney (5 blisters x 10 tubes)

Dosage form Box of 5 blisters x 10 tubes x 2ml
Specifications Furosemide

Ingredient

Composition information	Content
Furosemide	20

Uses

Indications

Furosemide medicine 20mg/2ml is indicated in the following cases:

Treatment of acute pulmonary edema.

edema due to heart, liver, kidney and other edema.

The drug acts on the upward branch of the Henle straps, so it is classified as a group of diuretics. The main mechanism of action of Furosemid is to inhibit the co-transport system Na+, K+, 2CI-, in the thick segment of the branch to the Henle straps, increasing the discharge of these electrolytes accompanied by increased water export exercises.

There is also an increase in Ca ++ and Mg ++ elimination. The diuretic effect of the drug is strong, thus leading to hypotension, but often weak. In patients with pulmonary edema, Furosemid causes increased venous volume, thus reducing the money burden for left ventricle before seeing the diuretic effect.

Dynamic pharmacokinetics

Furosemid absorb good through oral, diuretic effects appear quickly after 1/2 hours, reach a maximum concentration after 1-2 hours and maintain the effect from 4 - 6 hours. Anti -hypertension effect is longer. When intravenous injection, the effect of the drug is shown after about 5 minutes and lasts about 2 hours. For patients with severe edema, the biological use of the drug is reduced, possibly due to the direct effect of reducing the absorption of the digestive tract.

Furosemid's absorption may be extended and can be reduced by food. One third of the absorption drug is eliminated through the kidneys, the rest is eliminated through the urine, mainly in the form of non -metabolic, completely eliminated drugs for 24 hours.

Furosemid passes through the placenta and into breast milk.

Before taking Furosemide injection solution 20mg Vidipha treat acute pulmonary edema, heart, liver, kidney (5 blisters x 10 tubes)

How to use

Furosemide medicine 20mg/2ml used intramuscularly, slow intravenous injection or intravenous infusion (when diluted with appropriate solvent).

Dosage

Supporting treatment:

In case of emergency, or when orally or oral, intramuscularly or intramuscularly 20 - 40mg or necessary may be higher. If the dose is greater than 50mg, the intravenous injection should be injected slowly. To treat pulmonary edema, the initial slow intravenous injection is 40mg. If the response is not satisfactory within an hour, the dose may increase to 80mg, slow intravenous injection.

For children the dose of the injection is 0.5 - 1.5mg/kg/day, up to 20mg/day.

High -dose therapy:

Treatment of urinary tract - anuria in acute or chronic renal failure, when the glomerular filtration level is less than 20ml/ min, take 250mg of dilute Furosemid in 250ml of appropriate transmission, transmitted for an hour. If the diuretic effect has not met an hour after the transmission of the dose can increase to 500mg phase with the appropriate number of transmission and the transmission time about 2 hours.

If the diuretic effect is not satisfactory 1 hour after the end of the second end, then the third dose: 1 gram of Furosemid is continued in 4 hours, the transmission speed does not exceed 4mg/ min. If the maximum dose of 1 gram of intravenous infusion does not work, the patient needs artificial dialysis.

Can be used to remind the dose effectively after 24 hours or can continue by oral (500mg oral equivalent to 250mg of infusion). After that, the dose must be adjusted depending on the patient's waterlogging.

Treatment of chronic renal failure, the initial dose is 250mg can be used orally. When necessary, it is possible to add 250mg every 4 hours, maximum of 1.5g/24 hours, special cases can be up to 2g/24 hours. The dose dose depends on the response of the patient. However, not long -lasting.

While using high doses, it is necessary to check the monitoring of water -electrolytes, and especially in people with shock, must monitor blood pressure and circulating blood volume to adjust, before starting this therapy. This high -dose therapy is contraindicated in renal failure due to kidney or liver toxic drugs, and in renal failure combined with liver coma.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Expression:

Water and electrolyte imbalance include: headache, muscle weakness, cramps, thirst, blood pressure, anorexia, fast pulse.

Management:

Compensate for the amount of water and electrolytes lost.

What to do when forgetting a dose?

Side Effects

When using Furosemide 20mg/2ml, you may experience unwanted effects (ADR).

Unwanted effects mainly occur during high doses (accounting for 95% of harmful reactions). The most common is the electrolyte imbalance (5% of patients have been treated), which occurs mainly in patients who reduce liver function and with patients with renal impairment when treating high doses. Some cases of light infections have also been reported.

Common: Reducing blood volume in case of high dose therapy. Hypotenary pressure vertical; Hypotension, sodium -hypotension, hypoxemia, hypocalcemia, hyperiemia, hyperuricemia, testing due to hypothermia.

Few: nausea, vomiting, digestive disorders.

Rarely: leukopenia, thrombocytopenia, loss of granulocytes; Skin rash, vasculitis, paresthesia; Hyperglycemia of blood glucose, urinary glucose; Tinnitus, recovery hearing (at high doses).

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Furosemide medicine 20mg/2ml contraindicated in the following cases:

Sensitive to Furosemid and with sulfonamid derivatives, such as sulfamid cure diabetes.

Money for liver, liver coma.

Animal or kidney failure due to toxic drugs with kidneys or liver.

Be cautious when using

Caution for patients with prostate hypertrophy or difficult urine because it can promote urinary urination.

The ability to drive and operate machinery

There is no document.

During pregnancy

Thiazid, thiazid diuretics and straps diuretics evenly through the fetus fence into the fetus and causing water disorders and electrolytes for the fetus. With thiazid and conducting many cases of platelet reduction in newborns have been notified. This risk also appears after using diuretics such as Furosemid and Bumetamid.

Therefore, in the last 3 months of pregnancy, the drug is only used when there is no alternative medicine, and only at the lowest dose in a short time.

The period of breastfeeding

using Furosemid during breastfeeding is at risk of inhibiting milk secretion. This case should stop breastfeeding.

Drug interaction

may occur when using Furosemid in combination with the following drugs:

cephalothin, cephaloridin because of increased kidney toxicity.

Lithi salts increase lithium/ blood levels, which can be toxic. Should avoid using if you cannot monitor the blood lithium tight.

aminoglycozid increases the toxicity of the ears and kidneys, should be avoided.

cardiacid glycozide increases toxicity due to hypoglycemia. Need to monitor blood potassium and electrocardiograms.

Anti -inflammatory drugs that reduce diuretic effects.

corticosteroid increases k+.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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