Furosemide Mekophar medicine for edema treatment, hypertension (10 blisters x 30 tablets)

Dosage form Box of 10 blisters x 30 tablets
Specifications Furosemid

Ingredient

Composition information	Content
Furosemid	40mg

Uses

indications

Furosemid 40mg drug is indicated in the following cases:

edema in congestive heart failure, kidney disease and cirrhosis.

Support the treatment of acute pulmonary edema. Learning

Furosemid is a diuretics Sulfonamid, the mechanism of action is mainly inhibiting the Na+, K+, 2Cl-2Cl transport system in the thick segment of the branch on the Henle straps, increasing the excretion of these electrolytes accompanied by increased water export exercises. The drug also reduces the reabsorption of Na+, 2Cl- and increases the excretion of K+ in the distance and can work directly on the nearby tube. Furosemid does not inhibit the anhydrase carbon dioxide and non -antagonistic with aldosteron. Furosemid increases the elimination of Ca2+, Mg2+, hydrogen, ammonium, bicarbonate and maybe even the kidney phosphate.

Dynamic pharmacokinetics

Furosemid is quickly absorbed through the gastrointestinal tract, bioavailability is about 60 - 70%, but absorbed and erratic, affected by the form of medicine, disease processes and the presence of food. Born can be reduced to 10% in kidney disease, increasing slightly in liver disease. About 99% of blood furosemids are attached to plasma albumin. Furosemid is excreted mainly through urine, largely in the form of non -metabolic. The sale time is from 30-120 minutes in normal people, prolonged in newborns and people with liver and kidney failure. Furosemid passed the placenta and distributed into breast milk. The clearance of Furosemid does not increase when hemolysis.

Before taking Furosemide Mekophar medicine for edema treatment, hypertension (10 blisters x 30 tablets)

How to use

Take oral use.

Dosage

suitable:

Adults and the elderly: Start with 40mg in the morning and adjust the dose based on drug response. Maintain with 20mg/day or 40mg for the following days, increase the dose when persistent edema up to 80mg or more than 1-2 doses/day or interrupt. In severe cases, Furosemide dose may be required to be adjusted up to 600mg/day.

Adults and elderly people take initial dose 250mg/day; If necessary, the dose is higher, increasing step by step with 250mg, can be taken every 4 - 6 hours to the maximum single dose of 2g.

High blood pressure:

Adults and older people 40 - 80mg/day, separate or coordinated with other antihypertensive drugs.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? However, in patients with symptoms of overdose within 1 hour after drinking, consider using activated carbon (50g for adults, 1 g/kg for children).

Observe at least 4 hours, monitor heart rate and blood pressure. Treatment of hypotension and dehydration with appropriate intravenous injection solutions.

Monitor the amount of urine and electrolytes in serum (including chloride and bicarbonate). Electrolyte balance.

Patients should be advised to be discharged from the hospital to seek medical intervention if the symptoms develop later. Actively monitor for timely measures.

What to do when you forget 1 dose? If you are taking the medication regularly, take the medication as soon as possible, but skip the dose if you are near the next dose time. Do not take two doses at the same time.

Side Effects

When using Furosemid 40mg, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Blood and lymphatic system: platelet reduction.

Eye: visual disorders

Blood and lymphatic system: Eosin hypernagus, leukopenia, bone marrow inhibition. AGEP and Dress.

Instructions on how to handle ADR

Request to monitor clinical status:

Cardiac arrhythmia: If happened, stop immediately Furosemid.

Liver damage.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Furosemid 40mg contraindications in the following cases:

Hypersensitivity to Furosemid, sulfonamid derivatives, or any ingredients of the drug. Liver coma with cirrhosis. Therefore, it is not used to treat hypertension for the elderly.

Addison disease.

Be cautious when using

Furosemid is not recommended for:

In patients at high risk for kidney disease due to radioactive substances, should not be used to diuretic as part of the preventive measure for kidney disease due to radioactive substances.

Special warning and/or reducing dose when necessary:

Older patients. Closely monitor patients with part of the urinary tract. Addison). Treatment of blood calcium hypercalcemia with high doses of furosemids reduces liquid and electrolyte, supplementing liquid and electrolyte adjustment is necessary.

Patients are at risk of hypotension. Careful monitoring of water and electrolytes must be monitored. Furosemid occupies Bilirubin's place at the albumin position, must be used carefully in children with jaundice. And patients with other pathological conditions are at risk of lowering blood pressure.

The ability to drive and operate machinery

Precautions when using this drug for train drivers or operating machines, people working on high and other cases because the drug can cause tinnitus, reduce power.

Pregnancy

Furosemid may affect the fetus due to reducing the mother's blood volume. There is evidence of water stasis that occurs in pregnancy when the mother is treated with Furosemid. There is no sufficient studies on drug influence on pregnant women, so only use Furosemid when the benefits on the mother are greater than the risk for the fetus.

breastfeeding period

using Furosemid during breastfeeding is at risk of inhibiting milk secretion. Lactating women should stop breastfeeding if taking the drug is necessary.

Medicinal interaction

when using simultaneously Furosemid with cardiac glycosides, diuretics, anti -hypertension or other drugs with potential for reducing blood pressure.

The toxic effects of kidney toxic drugs may increase when used simultaneously strong diuretic such as Furosemid.

Anti-psychotic drug- Furosemid causes hypokalemia will increase the risk of heart toxicity.

Increased risk of ventricular arrhythmia with Amisulpride or Servindole. Increasing hypotension effect with phenothiazine.

Anti -arrhyths (including amiodarone, disopyramide, flecainide and sotalol): the risk of heart poisoning. The effects of lidocaine, tocainid or mexiletin may be opposed by Furosemid.

cardiac glycosides: Hypotension and electrolyte disorders increase the risk of cardiomatic toxicity. Need to monitor blood potassium and electrocardiograms.

The drug extends the QT interval: Increasing the risk of toxicity for electrolytes caused by Furosemid.

Periodic medication: Increasing hypotension effect with moxisylyte (thymxamin) or hydralazin.

Other diuretic: Diuretics can obviously occur when using Furosemid with Metolazon. Increasing risk of hypokalemia with thiazids.

Renin inhibitors: Aliskiren reduces Furosemid level in plasma.

Nitrate: Increasing hypotension effect.

Lithi: Lithi concentration may increase when lithium is used simultaneously with Furosemid, resulting in increased lithium toxicity.

Sucralfat: may reduce the absorption of the stomach - intestines for Furosemid.

NSAID: Increased risk of kidney toxicity. Indometacin and ketorolac can cause antagonism of Furosemid.

Salicylate: Effective can be stimulated by Furosemid. Salicylic toxicity can be increased by Furosemid.

Antibiotics: Increased risk of hearing nerve toxicity with aminoglycosides, polixin or vancomycin. Increased risk of kidney poisoning with aminoglycosides or cefaloridin. Furosemid may reduce serum vancomycin levels after heart surgery. Increased risk of hypoglycemia with trimethoprim. The impaired renal function can develop in patients treated simultaneously with high -dose Furosemid and Cephalosporin.

Antidepressant drugs: Increases the effect of lowering blood pressure with Maois. Increased risk of hypotension with standing posture with TCAS. Increasing risk of hypokalemia with reboxetine.

Hypoglycemic drugs: Effective hypoglycemia is antagonistic by Furosemid.

Anti -epileptic drugs: Increased risk of hypoglycemia with carbamazepine. Diuretic effects are reduced phenytoin.

Antihistamine - Hypotension with an increased risk of heart toxicity.

Antivopeders: Increased risk of hypokalemia and kidney poison with amphotericin.

Sedative and sleeping pills increase the effect of chloral or triclorfo that can replace the thyroid hormone from the linked position.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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