Fuxicure-400 gracure treatment for osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Celecoxib

Ingredient

Composition information	Content
Celecoxib	400mg

Uses

indicated

Celecoxib is assigned to:

Anti -inflammatory, analgesic in osteoarthritis.

rheumatoid arthritis.

Stiffness of the vertebrae.

Celecoxib is also indicated to reduce acute pain and dysmenorrhea.

Pharmacology

Celecoxib is a nonsteroidal anti-inflammatory drug, selective inhibition of cyclooxygenase-2 (COX-2), has anti-inflammatory, analgesic, fever-reducing effects.

The mechanism of action of Celecoxib is considered to be a prostaglandin synthesis inhibitors, mainly through the inhibitory effect of isenzyme cycloxygenase- 2 (COX-2), resulting in reducing the formation of Prostaglandin precursors.

Different from the majority of nonsteroidal anti-inflammatory drugs before, Celecoxib does not inhibit isenzyme cyclooxygenase-1 (COX-1) with human treatment concentrations. Cox-1 is a structural enzyme with most tissues, large and platelet leukocytes. Cox-1 participates in thrombosis (such as thrombocytopenia to stop training) to maintain the protective mucosa fence of the stomach and kidney function (such as maintaining kidney perfusion). Due to not inhibiting COX-1, Celecoxib is less likely to cause side effects (for example, platelets for stomach mucosa), but can cause side effects in the kidneys similar to non-selective nonsteroidal anti-inflammatory drugs

Pharmacokinetics

absorption

After taking about 3 hours, the peak concentration of Celecoxib in plasma. With a dose of 100 - 200 mg used in clinical, the peak concentration of plasma and the area under the curve (AUC) of Celecoxib is proportional to the dose.

Distribution

In healthy people, Celecoxib is strongly attached to protein - plasma when used with dose.

Metabolism

Celecoxib metabolism mainly via cytochrom P450 209 in the liver. Found in people with 3 metabolites: the first alcohol, the corresponding carboxylic acid and glucuro-complex, these metabolites are all inhibited inhibitors, or COXG.

Elimination

Celecoxib excreted mainly through metabolism in the liver. In feces and urine, there are very few mother substances that have not yet metabolized.

Before taking Fuxicure-400 gracure treatment for osteoarthritis (3 blisters x 10 tablets)

How to use

oral medication 01 times or divided into 2 times equally, all have the same effect in the treatment of bone - joint degeneration. For rheumatoid arthritis, the dose should be divided evenly into 2 times. The dose is up to 200 mg/time 2 times a day, can be taken without paying attention to the meal, higher doses (meaning 400 mg/time 2 times a day) must be taken at meals (along with food) to improve absorption.

Dosage

To treat bone - joint degeneration, the dose must be adjusted according to the needs and response of each patient, patients should find the lowest dose that is effective and effective.

Fuxicure dose for osteoarthritis treatment:

Normal doses: 200 mg/day oral or divided into 2 equal doses.

Fulicure dose of rheumatoid arthritis in adults:

Normal dose: 100 - 200 mg/time 2 times a day, higher doses (400 mg x 2 times/day) does not work better than the dose of 100 - 200 mg x 2 times/day.

Fuxicure dose in colorectal polyps:

The dose of 400 mg/time taken 2 times a day. According to the manufacturer, the safety and effectiveness of the therapy has not been studied over 6 months.

Fulicure dose of throbbing and menstrual pain:

The usual dose in adults 400 mg oral 1 time, followed by 200 mg if needed on the first day. To continue analgesic, can be taken for 200 mg daily, if necessary.

The usual dose in the elderly (over 65 years old):

No dose adjustment, although the concentration of drugs in plasma. However, for the elderly with a body weight of less than 50 kg, the lowest recommended dose must be used at the beginning of treatment.

Fulicure dose for kidney failure:

has not been researched and is not recommended for kidney failure. If it is necessary to use Celecoxib for people with severe renal failure, careful monitoring of kidney function. The manufacturer has no special recommendations on adjusting the dose for people with chronic kidney failure.

Fuxicure dose for patients with liver failure:

has not been studied. According to the manufacturer, not for patients with severe liver failure. For medium liver failure, the manufacturer recommends a dose reduction of about 50%.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Sleeping, drowsiness, nausea, vomiting, epigastric pain, often recovered when treated. The gastrointestinal bleeding may be encountered.

Handling

If NSAID overdose, symptomatic treatment and support treatment. There is no specific antidote.

If new poisoning within 4 hours and there are overdose symptoms, can be indicated and/or take activated carbon and/or drink osmosis.

In case of emergency or overdose, immediately call the 115 emergency center or visit the nearest local health station.

In addition, you need to record and bring the list of drugs you have used, including prescription and non -prescription drugs.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Fuxicure 400, you may experience unwanted effects (ADR).

The most unwanted effect is:

Headache.

Abdominal pain. indigestion.

diarrhea.

Nausea.

Insomnia.

Other unwanted effects include:

Renal failure.

heart failure.

High blood pressure. chest pain. tinnitus. deaf. gastric ulcer.

blurred vision.

worry.

Sensitive reactions to light.

Keep water.

Symptoms like flu, drowsiness and fatigue.

Instructions on how to handle ADR

Notify the doctor the side effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Fuxicure 400 drug contraindicated in the following cases:

Do not use Celecoxib for patients with hypersensitivity to any component of the drug, patients with allergies to sulfonamid, patients with asthma, urticaria or allergic reactions due to abnirin or other nonsteroidal anti -inflammatory drugs. There have been reports on severe, sometimes lethal reactions, with nonsteroidal anti -inflammatory drugs in these patients.

Severe heart failure.

Severe renal failure (Creatinine clearance coefficient below 30 ml/min). Severe liver failure.

Inflammation (Crohn's disease, ulcerative colitis).

Do not use Celecoxib to relieve pain in coronary artery surgery in the treatment of myocardial ischemia.

Be cautious when used

Patients using nonsteroidal anti -inflammatory drugs (NSAID) including Celecoxib may be at risk of cardiovascular disease or stroke than patients who do not use these drugs.

These risks can occur suddenly and can lead to death. These risks also occur higher in patients using NSAID drugs in the beginning patients who have themselves or others in the family are or have had cardiovascular disease or stroke, smokers, patients with high blood cholesterol, high blood pressure or diabetes, should notify the doctor.

Do not use Celecoxib for women who are pregnant in the last 3 months to avoid the risk of early closing the ductus arteriosclerotic. Only use Celecoxib for pregnant women when the benefits are greater than the risks that may occur for the fetus.

The ability to drive and operate machinery

Fuxcure does not affect the ability to drive and operate machinery.

Pregnancy

should not use Celecoxib for women who are pregnant in the last 3 months to avoid the risk of early closing the ductus arterioscler. Only use Celecoxib for pregnant women when the benefits are greater than the risks that may occur for the fetus.

breastfeeding period

Celecoxib excreted through Cai mouse milk with equivalent concentration in plasma. It is not clear whether Celecoxib whether or not the mother milk is. Because there are many drugs through breast milk and because of the serious reaction of celecoxib breastfeeding, it is necessary to decide or the mother stops the drug or stops breastfeeding, taking into account the importance of Celecoxib to treat the mother.

Drug interaction

Celecoxib metabolizes mainly through Cytochrom P450 2C9 in the liver, so be careful when coordinating Celecoxib with P450 inhibitors 249.

Angiotensin (ACE): NSAIDs reduces the anti -hypertension effect of ACE inhibitors.

Furosemid: In some patients, NSAIDs can reduce the effect of waste na*/urine of Furosemid.

Simultaneous use of Celecoxib with aspirin or other NSAID drugs (ibuprofen, naproxen, ...) may increase the risk of digestive tract ulcer.

fluconazole increases blood cells in the blood due to the inhibition of celecoxib metabolism in the liver.

Celecoxib increases the level of lithium in the blood. Therefore, closely monitor the level of lithium in the blood when used simultaneously with Celecoxib.

Storage

Store drugs at less than 30 ° C, leave a cool dry place, avoid direct light, moisture prevention.

Do not store drugs in the bathroom, in the freezer. Each drug may have different storage methods. Please read the instructions on the packaging carefully or ask the doctor.

Do not let the product in children can be with.

Notice the appearance of the product, if the product shell shows signs of openness, the product is discolored, watery or deformed, then do not use the product. If you want to destroy it, you will not be thrown on the sewer, the toilet ... Instead, you should consult a doctor and pharmacist to destroy the drug safely, without causing environmental pollution.

Expiry date: 36 months from the date of manufacture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.