Galamento 400mg medicine for treatment of epilepsy and neuropathy (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Gabapentin

Ingredient

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Composition information	Content
Gabapentin	400mg

Uses

Indications

Galamento 400 drug is indicated in the following cases:

Sythematic treatment for local epilepsy whether or not there are secondary comprehensiveness in adults and children over 12 years old. up. The mechanism of action is unknown, in vitro studies using gabapentin marked with radioactive material have shown a new peptide location in mouse brain tissue including new shell zones and hippos legs, this feature may be related to the anti -convulsions of the drug. Gabapentin reduces the release of neurotransmitters with monoamine structure on in vitro. Gabapentin animals enter the brain easily and prevent epilepsy due to electrical shock, chemical agents including GABA synthesis inhibitors and seizures on epilepsy models.

pharmacokinetic

absorption

Gabapentin is absorbed through the gastrointestinal tract under a saturated mechanism, which means that the absorption is not proportional to the dose that to a certain saturation level, the absorption decreases. Gabapentin's peak concentration is achieved after drinking for 2 hours and reaches a stable condition in 1-2 days.

Distribution

Gabapentin is widely distributed throughout the body but very little plasma protein binding.

Metabolism

gabapentin is not metabolized, most of the dose is excreted intact through the urine, the rest is excreted through the stool. The sale time is about 5 - 7 hours in people with normal kidney function.

Elimination

The drug is excreted in breast milk. The elimination of drugs is reduced in elderly patients, patients with renal impairment and can be eliminated through dialysis.

Before taking Galamento 400mg medicine for treatment of epilepsy and neuropathy (5 blisters x 10 tablets)

How to use

oral medication during or outside meals.

Dosage

Anti -epilepsy in adults and children over 12 years:

Effective dose is from 900 mg - 1800 mg per day. Can start with capsules 300 mg or 400 mg, 3 times at the first day or the standard as follows:

300 mg or 400 mg, 1 time in the first day.

300 mg or 400 mg, 2 times in the 2nd day. When using high doses can be divided into 4 drinks. There are a few cases of 3600 mg/day, which are also used for a relatively short time.

For people with renal failure:

Need to adjust the dosage for patients with renal failure depending on the creatinine clearance as follows:

Creatinine clearance Total dosage of the day The time

15 - 29 ml/minute 300 mg, divided 3 times

The loading dose is 300 - 400 mg and then reduced to 200 - 300 mg after every 4 hours of fertilizer.

Children from 6 to 12 years old:

The first day: 10 mg/kg/day, divided 3 times.

Monday: 20 mg/kg/day, divided 3 times. The total dose of the day is divided into 3 drinks.

Children from 3 to 6 years old:

3 days to get a dose of 25 - 30 mg/ kg/ day for children 3-4 years or 25 - 30 mg/ day for children 5 years old or more. The total dose of the day is divided into 3 drinks.

Dosage does not exceed 1800 mg/day, divided into 3 times, the standard starting dose is similar to the dose of epilepsy in adults. Then increase the dose to up to 1800 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If you miss an overdose, take the patient to the nearest medical facility for appropriate treatment.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed. The remaining doses should be taken on time.

Side Effects

When using Galamento 400, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Dreaming, dizziness, loss, fatigue, fever, opposition, confusion and emotional disorders, depression, anxiety, irritability, abnormal thoughts, convulsions, hyperactivity, speech, or forgetting, tremor, insomnia, headache, abnormalities, abnormal coordination, eyeball vibration, increase or loss of vision, visual disorders.

blood and hematopoietic system: leukopenia. weakness, pain, difficulty living, symptoms like the flu.

Respiratory: pneumonia, respiratory bacteria Increasing liver function indicators such as SGOT (AST), SGPT (ALT) and Bilirubin.

Metabolism: Hypoglycemia (often found in patients with diabetes), loss of consciousness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Galamento 400 drug is contraindicated in the case of: hypersensitivity to gabapentin or any ingredients of the drug.

Precautions when using

Monitoring of gabapentin concentrations in plasma is not necessary. Gabapentin can be used in combination with other anti -epileptic drugs without caring for the change of gabapentin concentration or the concentration of other anti -epileptic drugs in plasma.

All dose reduction, stop or replacement with other convulsions must be done slowly for at least 1 week to avoid the occurrence of continuous seizures for patients due to sudden suspension.

In general, Gabapentin is not effective in treating seizures of awareness.

Each day should take the drug at the same time, to maintain the blood concentration in the blood stable.

Gabapentin may give a false positive result with proteinuric detection tests.

Use cautiously for people with mental disorders.

The ability to drive and operate machinery

Do not use drugs for drivers or operating machinery.

Pregnancy

only used for pregnant women when the treatment benefits bring superior risks on the fetus.

Breastfeeding period

The drug goes into breast milk, the influence on breastfed babies is not well known. Therefore, the drug should only be used for women during breastfeeding when the treatment benefits are clearer than the risks.

Medicinal interaction

should be avoided in combination with the following drugs because it can cause interactions: antacids containing aluminum salt and magnesium salt, cimetidine.

Storage

This drug needs to be stored where the temperature does not exceed 30 ° C.

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