Galeptic 300 Hasan medicine supports support in local epilepsy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Gabapentine

Ingredient

Composition informationContent
Gabapentine300mg

Uses

Indications

Treatment of support in local epilepsy.

Treatment of pain caused by peripheral nerves.

Pharmacological

gabapentin is an anti -epileptic drug, the mechanism is unclear. The chemical structure of Gabapentin is similar to neurotransmitter inhibitors, Gama-Aminobutyric Acid (GABA), but Gabapentin does not directly affect GABA receptors, does not change the structure, release, metabolize and recover GABA.

pharmacokinetics

absorption:

gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when the dose increases, bioavailability decreases). The drug reaches the peak concentration in plasma after drinking 2 hours and reaches a stable concentration after 1-2 days. The effective serum concentration of the drug has not been determined. The plasma concentration of gabapentin is from 2 mg/liter (2 micrograms/ml) to 20 mg/liter (20 micrograms/ml).

Birth is about 60% when used in a dose of 1.8 g/24 hours and does not correspond to the dose, if the dose increases over 1.8 g/24 hours, the bioavailability decreases. Birth is about 35% when used at a dose of 4.8 g/24 hours. Food less affecting the speed and level of absorption.

Distribution:

gabapentin is distributed throughout the body, entering breast milk, linking with very low plasma proteins (

Metabolism:

gabapentin is almost no metabolism in the body.

Era:

Elimination mainly through the kidneys in constant form. Gabapentin's exhaust time is about 5 to 7 hours in people with normal kidney function. In elderly patients and people with impaired renal function, the clearance of plasma gabapentin decreases.

Gabapentin may be excluded from plasma by hemolysis, need to adjust the dose in these patients.

Before taking Galeptic 300 Hasan medicine supports support in local epilepsy (3 blisters x 10 tablets)

How to use

gabapentin is used by oral, time of drinking does not depend on meals.

Gabapentin is used as auxiliary drugs to coordinate with other anti -epileptic drugs. Effective use.

Before stopping the drug or switching to other anti -epileptic drugs, it is necessary to reduce the dose slowly within 7 days.

Dosage

anti -epilepsy:

Adults and children over 12 years:

  • First day: 300 mg x 1 time/day.
  • Monday: 300 mg/time x 2 times/day.
  • Tuesday: 300 mg/time x 3 times/day.

    • After that, the dose may increase every step of 300 mg/day, depending on the response of the patient until the effective treatment is reached, usually 900 - 1800 mg/day, divided 3 times; Maximum not exceeding 2400 mg/day.

    Should divide the total daily dose for each drug and the medication distance should not exceed 12 hours. When using high doses can be divided 4 times/day.

    Children from 6 to 12 years old:

  • The first day: 10 mg/kg/day, divided 3 times.
  • Monday: 20 mg/kg/day, divided 3 times.
  • Tuesday: 25 - 35 mg/kg/day, divided 3 times.

    • The maintenance dose is 900 mg/day for children weighing 26 - 36 kg and 1200 mg/day for children weighing 37 - 50 kg, total doses/day are divided into 3 times.

    3 -year -old children to under 6 years old:

  • Starting dose: 10 - 15 mg/kg/day, divided 3 times.
  • Increase the dose in 3 days to get a dose of 25 - 30 mg/kg/day for children 3-4 years old.
  • For children 5 - 6 years old, the dose is 25 - 30 mg/day, the total dose/day is divided into 3 times.

    • Children under 12 years of age with impaired renal function:

    There is no evaluation of using gabapentin in this object.

    Patients with impaired kidney function and blood decline:

    Must reduce the dose and dose appropriately to be adjusted according to creatinine clearance, recommended as follows:

    Creatinine clearance (ml/minute)

    Dosage

    50 - 70

    600 - 1200 mg/day, divided 3 times

    30 - 49

    300 - 600 mg/day, divided 3 times

    15 - 29

    300 mg/day, divided 3 times

    300mg once a day, divided 3 times

    200 - 300mg (*)

    Treatment of pain due to peripheral nerves, shingles after shingles:

    Adults:

    Take no more than 1800 mg/day, divide 3 times or use as follows:

  • First day: 300 mg/time.
  • Monday: 300 mg/time x 2 times/day.
  • Tuesday: 300 mg/time x 3 times/day.
  • After that, the dose may increase by step 300 mg/day based on the patient's response until the maximum dose is 1800 mg/day, the total dose/day is divided into 3 times.

    • Elderly:

    Adjust the dose by kidney function.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when using overdose? Most cases of overdose recover after using supportive treatment. There may be drugs from the body by hemolysis.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Galeptic 300, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Neurological: Mobilizing loss of coordination, vibration of eyeball, fatigue, dizziness, drowsiness, memory reduction, impotence; Children from 3 to 12 years old have neurological problems such as anxiety, changing behavior (fussing, refreshing or depression, too excited, anti -opposition attitude ...).
    • digestive: indigestion, dry mouth, constipation, abdominal pain, diarrhea. Systemic: Foreign eagle, itching, skin rash, leukopenia. Respiratory: rhinitis, sore throat, cough, pneumonia, viral infection.
  • Eye: Eyes, vision loss.
  • Muscle muscle: joint pain, muscle pain.
  • Reproductive system: impotence.

    • Uncommon, 1/1000

  • Neurological: Memory loss, loss of language, depression, irritability or mental change, temperament, mild paralysis, decrease or loss of sex, headache.
    • digestive: digestive disorders, bleeding, stomatitis, loss or taste disorders. Cardiovascular: Hypotension, angina, peripheral disorders, suspense. liver: liver. Body: Weight gain.

    Rare, ADR

  • Neurological: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise function, mental disorders.
    • digestive: gastric ulcer - duodenum, esophagitis, colitis, rectal inflammation. Respiratory: cough, hoarseness, respiratory vascular seal, lung ventilation, pulmonary edema. eyes: itchy eyes, watery eyes, retinopathy, iritis.
  • Muscle muscle: cartilage, osteoporosis, back pain.
    • blood and lymphatic system: leukopenia, prolonged bleeding time. Systemic: Fever, Cold Run, Stevens-Johnson syndrome.

    Instructions on how to handle ADR

    Often mild or medium side effects and tend to decrease within 2 weeks when continuing treatment.

    Warnings

    contraindicated

    Galeptic 300 drugs are contraindicated in cases of sensitivity to gabapentin or any ingredients of the drug.

    Precautions when using

    Use cautiously for people with a history of mental disorders, people with impaired kidney function and hemolysis.

    The drug can cause false positive when testing proteinuria.

    Do not stop the drug suddenly because it can increase the frequency of seizures.

    If there is a suspected Stevens-Johnson syndrome, the drug must be stopped.

    The ability to drive and operate machinery

    gabapentin can cause dizziness, fatigue, drowsiness, dizziness, vision reduction ... Therefore, need to be careful to use the drug when operating train and machinery.

    Pregnancy

    only use drugs for pregnant women when they are really necessary and consider higher benefits than risks.

    breastfeeding period

    only use medication for breastfeeding women when they are really necessary and consider higher benefits than risk risks.

    Interactive drug

    When used simultaneously, gabapentin does not change the pharmacokinetics of commonly used anti -epileptic drugs such as carbamazepin, phenytoin, valproic acid, phenobarbital, diazepam.

    Anti -acid drugs reduce the bioavailability of gabapentin by about 20% due to the impact on the absorption of the drug. Gabapentin must be used after at least 2 hours of antacids.

    Storage

    Store in a dry place, temperature below 300C.

    Hasan - Dermapharm Joint Venture Company is one of the leading enterprises in research, development, production and commercialization of specialized pharmaceuticals meeting European quality standards. The production field of the company includes: tablets, tablets, hard capsules, powder, nuggets, water medicine, ice cream, ointment, powder and nuggets containing antibiotics of Cephalosporin group, powder and nuggets containing microorganisms.

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