Ganfort Allergan eye drops treatment Glaucoma open angle, glaucoma (3ml)

Dosage form Bottle x 3ml
Specifications Bimatoprost, timolol

Ingredient

Composition information	Content
Bimatoprost	0.3mg
Timolol	5mg

Uses

Indications

Ganfort drugs are indicated in the following cases:

Glaucoma open angle or glaucoma does not fully respond to beta blockers or similar substances Prostaglandin used on the spot. It is used to reduce the glaucoma (IOP), in addition the drug also increases the development of eyelashes.

Bimatoprost is a strong anti -glaucoma agent. It is a synthetic prostamide, with structure related to prostaglandin f 2α (PGF 2α).

Timolol is the Adrenergic Beta1 and Beta2 receptor receptor. The mechanism of low -glaucoma effects of beta blockers is unknown, but by fluorescent measurement and labeling, it is found that these drugs reduce the production of aquaculture. In addition, there is a slight increase in the output of the aquarium, Timolol has no stimulating beta, has no stable effect (non -anesthetic). Different from the pupils, Timolol has little or no regulating the elasticity of the pupils.

pharmacokinetic

absorption

Bimatoprost absorbed into the cornea. After taking drugs in adults, the bimatoprost effect is very poor and does not accumulate for a long time. After using once a day, the dose of 0.3mg/ml bimatoprost for both eyes for two weeks, the peak concentration of plasma is achieved within 10 minutes after taking the drug and reduced to 0.025ng/ml for 1.5 hours after the drug. The average value of CMAX and AUC 0 - 24 hours is equal on Saturday and 14 at about 0.08ng/ml and 0.09ng/ml.

Distribution

Bimatoprost moderately distributed into the body tissue and the integral distribution in humans is 0.67L/kg. In the blood, bimatoprost is mainly in plasma. Bimatoprost's plasma protein is about 88%.

Biological Change

Bimatoprost then undergo oxidation, N - Deethylation and Glucuronidation to form a range of diverse metabolites.

eliminate

Bimatoprost is excluded by excretion through the kidneys, up to 67% of the intravenous dose for healthy volunteers is excreted in urine, 25% of the dose is excreted through feces. Half life eliminates about 45 minutes, blood clearance is 1.5 liters/hour/kg.

timolol

Timolol's low -glaucoma effects are usually fast, appearing about 20 minutes after looking up the eye and reaching a maximum within 1-2 hours. Once the Timolol solution is 0.25% or 0.5%, the effect remains about 24 hours. After small eyes, can quantify Timolol in plasma, Timolol into breast milk. After finishing a 0.5% Timolol solution, twice a day, Timolol concentration in breast milk is 6 times higher than in plasma, in order 5,6 and 0.93ng/ml.

Before taking Ganfort Allergan eye drops treatment Glaucoma open angle, glaucoma (3ml)

How to use

eye drops.

Dosage

Maximum 1 drop into the eye, 1 time/day in the morning or evening, so at the same time every day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? If overdose occurs, symptomatic monitoring and treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using liverFort drugs, you may experience unwanted effects (ADR).

conjunctival conjunctiva, eyelash growth. ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Liverfort drug contraindicated in the following cases:

Contraindicated drugs in the case of patients with allergies or hyperplasitation with the ingredients of the drug.

Respiratory diseases regenerated including bronchial asthma or a history of bronchial asthma, severe chronic COPD.

Sinus slow heartbeat, pathological sinus syndrome, atrial sinus block, atrial atrial block II - III is not controlled by pacemaker, heart failure, heart shock.

Precautions when using

Patients with liver/kidney failure.

Patients with intraocularitis (inflammation may be more serious).

Patients without a lens.

Patients with artificial lenses with torn lens behind.

Patients already know that there is a risk factor for Phu Hoang Diem.

Patients with a history of cardiovascular disease and hypotension, heart block 1.

Patients with severe peripheral circulatory disorders (Raynaud phenomenon).

Patients with mild - medium COPD, spontaneous hypoglycemia or diabetes (drugs can cover signs and symptoms of acute hypoglycemia).

Patients with corneal disease (dry eye).

Safety and effectiveness have not been determined in children.

The ability to cause brown pigmentation in the iris can be permanent, can cover the signs of hyperthyroidism, causing veins after filter procedure.

The drug can reduce offset tachycardia and increase the risk of hypotension when used in combination with anesthesia.

Avoid drugs flowing on the cheek or other skin areas.

Remove contact lenses before the drug and wait for at least 15 minutes after young to bring.

The ability to drive and operate machinery

Be careful when used for driving objects and operating machinery.

Pregnancy

There is no study when used in pregnant women, avoiding use for this object. Only use if the benefits are higher than the risk.

Breastfeeding period

There is no study when used in nursing women, avoiding use for this object.

Medicinal interaction

Beta - adrenergic blockers of the body: The plus beta blocking effect.

Oral Calcium channel blockers, guanethidin, anti -arrhythmic drugs, digitalis glycosid, drugs that are similar to sympathetic and other anti -hypertension drugs: Additional effects lead to hypotension or significant slow heart rate.

CYP2D6 inhibitors: The strong body block block.

Storage

In a dry place, avoid light, temperatures below 25 ° C.

Other drugs

Disclaimer

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