Garosi Bluepharma treatment for infection (1 blister x 3 tablets)

Dosage form Box of 1 blister x 3 tablets
Specifications Azithromycin

Ingredient

Composition information	Content
Azithromycin	500mg

Uses

Indication

Garosi is indicated in the following cases:

azithromycin is indicated for use in cases of infections caused by sensitive bacteria such as lower respiratory tract bacteria including bronchitis, pneumonia, skin and soft tissue infections, otitis media , upper respiratory infections such as sinusitis , sore throat and amidanitis . Azithromycin should only be used for people who are allergic to penicillin, because of the risk of drug resistance.

In sexually transmitted diseases in both men and women, azithromycin is used to treat unproving genital tract infections due to chlamydia trachomatis or neisseria gonorrhoeea without multiple resistance.

Pharmacology

Azithromycin is a new antibiotic with a broad spectrum of the macrolide group, called azalid.

The drug has a strong bactericidal effect by attaching the ribosom of pathogenic bacteria, preventing their protein synthesis. However, there is also cross -resistance to erythromycin, so careful consideration when using azithromycin due to spreading macrolid -resistant bacteria in Vietnam, Azithromycin works well on Gram -positive bacteria such as Streptococcus, Pneumococcus, Staphylococcus Aureus.

Studies conducted in Vietnam show that these species are different from macrolid groups at about 40%; So partly the ability to use azithromycin is more or less limited. Some other bacteria strains are also very sensitive to azithromycin such as: corynebacterium diphtheriae, Clostridium perfringens, peptostreptoccus and propionibacterium acnes. Always remember that erythromycin -resistant microorganisms may also be resistant to azithromycin as Gram -positive strains, including Enterococcus species and most staphylococcus strains of methicilin are completely resistant to azithromycin.

azithromycin works well in Gram -negative bacteria such as: Haemophilus influenzae, parainfluenzae, and Ducreyi, Moraxella CatVrhalis, Acinetobacter, Yersinia, Legionella Pneumophilia, Bordetella Pertussis, and Parapertussis; Neisseria gonorrhoeae and campylobacter sp.

In addition, this antibiotic is also effective with Listeria Monocytogenes, Mycobacterium Avium, Mycoplasma Pneumoniae and Hominis, Ureaplasma Urealyticum, Toxoplasma Gondii, Chlamydia Trachomatis and Chlamydia Pneumoniae, Treponema Pallidum and Borrelia Burgdorferi. Azithromycin has a moderate effect on Gram -negative bacteria such as E. Coli, Salmonella Enteritis and Salmonella Typhi, Entobacter, Acromonas Hydrophilia, Klebsiella. The Gram -negative strains are anti -Azithromycin, Proteus, Serratia, Pseudomonas Aeruginosa and Morganella.

Overall, Azithromycin acts slightly weaker in Gram -positive bacteria than erythromycin, but stronger on some Gram -negative bacteria including Haemophilus.

Dynamic pharmacokinetics

azithromycin after drinking, widely distributed in the body, biological use about 40%.

Food reduces the ability to absorb azithromycin by about 50%. After taking the drug, plasma concentration is reached within 2 to 3 hours. The drug is distributed mainly in tissues such as lungs, tonsils, prostate glands, granulocytes and macrophages, ... higher than in the blood (about 50 times the maximum concentration found in plasma).

However, the concentration of the drug in the central nervous system is very low. A small amount of azithromycin has methyl reduction in the liver, and is eliminated through bile in the form of unchanged and partly metabolic form. About 6% of oral doses except for urine within 72 hours in the form of unchanged. Half life eliminates the last of the half -life of the half -life eliminated in soft tissues achieved after taking the drug from 2 to 4 days.

Before taking Garosi Bluepharma treatment for infection (1 blister x 3 tablets)

How to use

Used orally with a glass of water.

Dosage

drugs only used when prescribed by a doctor.

Azithromycin is used once a day, drink 1 hour before meals or 2 hours after eating.

Adults

Treatment of genital infections such as cervicitis, urethritis caused by chlamydia trachomatis infection with a single dose of 1 g.

Other indications (bronchitis, pneumonia , sore throat, skin and soft tissue infections): The first day of taking a dose of 500 mg, and use 4 more days with a single dose of 250 mg/day.

Elderly

Dosage by young people.

Children

The suggested dose for children on the first day is 10 mg/kg body weight and followed by 5 mg/kg daily, from Monday to the 5th day, drink once a day.

Note: This dose may vary depending on the doctor's instructions. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

There is no material overdose azithromycin, typical overdose of macrolid antibiotics is often reduced hearing, nausea, vomiting and diarrhea.

Management:

Stomach washing, and supportive treatment.

In case of emergency or overdose, immediately call the 115 emergency center or visit the nearest local health station.

In addition, you need to record and bring the list of drugs you have used, including prescription and non -prescription drugs.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Garosi 500 mg, you may experience unwanted effects (ADR).

Like erythromycin, azithromycin is a good tolerated drug, and the rate of unwanted effects is low (about 13% of patients). The most common is digestive disorders (about 10%) with symptoms such as nausea, abdominal pain, abdominal spasms, vomiting, flatulence, diarrhea, but usually mild and less occur than Erythromycin. It can be seen that the transient change in the number of neutrophils or temporary increase in the liver enzyme, sometimes there may be rash, headache and dizziness.

Hearing effects: long -term use in high doses, azithromycin can reduce the recovery of recovery in some patients.

Common, ADR> 1/100

Digestive: vomiting, diarrhea , abdominal pain, nausea.

Uncommon, 1/100> ADR> 1/1000

Body: Fatigue, headache , dizziness, sleep.

digestive: flatulence, indigestion, no appetite. skin: rash, itching. other effects: Vaginitis, cervix.

Rare, ADR

Body: Anaphylaxis.

skin: angioedema.

Liver: enzyme transaminase increases.

Blood: Montogeneous mitigation.

Instructions on how to handle ADR

Notice immediately to the doctor when encountering the unwanted effects of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Garosi medicine 500mg contraindicated in the following cases:

Not used for people with hypersensitivity to azithromycin or any antibiotic belonging to the macrolid group.

Be cautious when used

Careful when using azithromycin and other macrolids because of the ability to cause allergies such as vasodilation and anaphylaxis (although rarely).

As with other antibiotics, during the use of drugs, the signs of superinfection must be observed by bacteria that are not sensitive to drugs, including fungi.

Need to adjust the appropriate dose for kidney disease patients with creatinine clearance less than 40 ml/min.

Do not use this medication for people with liver disease, because the main excretion of the liver.

The impact of drugs when driving and operating machinery

does not affect.

Pregnancy

There are no adequate and controlled studies in pregnant women. Because animal reproductive research does not always predict the response on humans, it is only used for pregnant women when necessary.

The period of breastfeeding

There is no data to study the excretion ability of azithromycin by breast milk. Azithromycin should only be used when there is no other appropriate drug.

Interactive drug

Because food reduces the bioavailability of drugs by 50%, so Azithromycin is taken 1 hour before or 2 hours after eating.

Conducting chicken fungus: Do not use simultaneously azithromycin with chicken spurs derivatives because of its ability to poison.

Antacislets: When needed, azithromycin is only used at least 1 hour before or 2 hours after using antacids.

Carbamazepin: In pharmacokinetic research in healthy volunteers, no significant effect on carbamazepine concentration or their metabolic products in plasma.

cimetidin: pharmacokinetics of azithromycin is not affected if taking a dose of cimetidin before using azithromycin 2 hours.

Cyclosporin: Some macrolid antibiotics hinder the metabolism of cyclosporin, so it is necessary to monitor the concentration and adjust the dose of cyclosporin.

Digoxin : For some patients, Azithromycin can affect digoxin metabolism in the intestine. Therefore, when using these two drugs simultaneously, it is necessary to monitor the micro -concentration that has the ability to increase digoxin content.

Methylprednisolon: Studies conducted on healthy volunteers have proved that azithromycin has no significant effect on the pharmacokinetics of Methylprednisolon.

Theophylin: There has not been any effect on pharmacokinetics when 2 drugs azithromycin and theophylin are also used in healthy volunteers, but generally should monitor theophylin concentration when using these two drugs for patients.

Warfarin: When studying pharmacokinetics on healthy volunteers using a single dose of 15 mg of warfarin, azithromycin does not affect anticoagulant effects. These 2 drugs can be used at the same time, but still need to monitor the patient's blood clotting time.

Storage

Store drugs at less than 30 ° C, leave a cool dry place, avoid direct light, moisture prevention.

Do not store drugs in the bathroom, in the freezer. Each drug may have different storage methods. Please read the instructions on the packaging carefully or ask the doctor.

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