Gasmotin 5mg Eisai treatment for chronic gastritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Mosapride citrate

Ingredient

Composition information	Content
Mosapride citrate	5mg

Uses

Indications

Gasmotin 5 mg is indicated in the following cases:

Gastric - intestinal symptoms related to chronic gastritis (heartburn, nausea/vomiting).

In the experiment of the empty gastric emptiness in healthy adults and patients with chronic gastritis, the only dose of these 5 mg increases the emptiness of the stomach.

Stomach movement effect

This drug increases gastric and duodenal movement after dog meals.

The effect of enhancing stomach empty

This drug enhances the emptiness of the stomach containing liquid (in mice and rats) and thick substances (in rats). The effect of enhancing the empty gastric hollow decreases after the dose is repeated for 1 week (in rats).

Mechanism of impact

This drug is a selective receptor owner 5 - HT4. The drug is thought to stimulate the receptor 5 - HT4 in the stomach -intestine plexus, increasing acetylcholin release, leading to enhancement of stomach movement and gastric emptiness.

pharmacokinetic pharmacokinetics

Plasma concentration

(5 healthy adults fasting, single dose of 5mg mosapride citrate).

tmax (h) cmax (ng/ml)

t1/2 (hour) aUC0-∞ (ng*hour/ml)

0.8 ± 0.1 0.2 67 ± 8

The ratio of cohesion to plasma protein

99.0% [In test tubes, human serum, at a concentration of 1 μg/ml, super filter or balanced mental method].

Main metabolites and metabolic lines

Main metabolites: DES-4-Fluorobenzyl compound.

Metabolic line: Mosapride Citrate is metabolized mainly in the liver, where the 4-Fluorobenzyl group is taken away, followed by the oxidation of the morpholin ring in position 5, and the benzene hydroxide in position 3.

The excretion line and the excretion ratio

Excretion line: In urine and feces.

The excretion ratio: In urine collected 48 hours after taking the drug, 0.1 % is excreted in the form of constant compound and 7.0 % is excreted in the form of aneurized metabolitus (DES-4-fluorobenzyl compound). (Healthy adults, single dose 5 mg Mosapride Citrate when hungry)

Metabolic enzymes

Cytochrome p-450 family: mainly CYP3A4.

Before taking Gasmotin 5mg Eisai treatment for chronic gastritis (3 blisters x 10 tablets)

How to use

Use oral with a glass of water, drink before or after meals.

Dosage

For adults, the daily dose is usually 15 mg of mosapride citrate in anhydrous form, divided into 3 times before or after meals.

Note: This dose may vary depending on the doctor's instructions. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

According to the results of the study using oral Gasmotin for a long time in the species encountered (rats for 104 weeks and rats for 92 weeks), the dose is from 30 to 100 mg/kg/day 330 times higher than the usual dose of clinical, showing an increase in tumor ratio (liver cell tumor and thyroid cyst cell tumor).

Experience overdose in humans:

There is no data on overdose, no overdose of the drug.

Overdose:

There is no specific antidote. Should apply general support treatment in all cases of overdose.

In case of emergency or overdose, immediately call the 115 emergency center or visit the nearest local health station.

In addition, you need to record and bring the list of drugs you have used, including prescription and non -prescription drugs.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Gasmotin 5 mg, you may experience unwanted effects (ADR).

In clinical trials, side effects are recorded in 40 of 998 cases (4.0%). The main side effects are diarrhea/liquid stool (1.8%), dry mouth (0.5%), discomfort (0.3%), etc.The abnormal subclinical test values are noticed in 30 of 792 cases (3.8%), mainly eosinophilia (1.1%), Triglyceride (1.0%), AST (GOT), ALT (GTP) 0.4%) (at the time of approved drugs).

Clinical side effects

Acute hepatitis, liver and jaundice disorders (each type below 0.1%).

Because of the acute hepatitis, serious liver dysfunction comes with a significant increase in AST (GOT), ALT (GPT) and Gamma - GTP, etc. and jaundice that can occur and some deaths, should be carefully needed and if any abnormalities have to stop taking the drug immediately and apply appropriate measures.

Other side effects

Classification

gastrointestinal - gastrointestinal tract diarrhea/liquid stool, dry mouth, abdominal pain, nausea/vomiting, changing taste the feeling of abdominal distention, numbness of the mouth (including tongue and lips, etc.) ALP, gamma-GTP and Bilirubin Other difficult to live, increase triglycerides run

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Gasmotin 5 mg contraindicated in the following cases:

Patients with a history of hypersensitivity to Mosapride or any component of excipients.

Precautions when using

when allocating drugs

For drugs in the click (PTP blister), the patient should be taught to remove the drug from the blister before use. [It is noted that if swallowing PTP bags, sharp corners can puncture the esophagus mucosa, causing serious complications such as mediastitis].

Other caution

When giving rodents of Mosapride Citrate at a dose of 100 to 330 times the dose is recommended (ie 30 to 100 mg/kg/day) for a long time (104 weeks in mice, 92 weeks in mice), observed increased ratio of liver cell glands and cyst cell glands.

The ability to drive and operate machinery

has not been recorded.

Pregnancy

should not use this medication for pregnant women, women may be pregnant, unless the benefits are expected than possible risks due to treatment. The safety of this drug in pregnant women has not been proven.

Breastfeeding period

Should avoid using this medication for nursing mothers. If it is necessary to use, the mother should stop breastfeeding during treatment. Experiments on animals (rats) show the drug excreted through breast milk.

Medicinal interaction

Be cautious when used in combination (should be cautious when using Gasmotin simultaneously with the following drugs.)

Drugs

Signs, symptoms and treatment

mechanisms and risk factors

Atropin Sulfate and

Butylscopolamin bromid, etc.

Storage

Store drugs at less than 30 ° C, leave a cool dry place, avoid direct light, moisture prevention.

Other drugs

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