Gel Azaduo Medisun treats mild to medium acne (15g)

Dosage form Tube x 15g
Specifications Adapalene, Benzoyl Peroxide
Ingredient Acne, acne, pimples

Ingredient

Thành phần cho 1g

Composition informationContent
Adapalene0.1%
Benzoyl Peroxide2.50%

Uses

Indications

gel Azaduo Medisun 15 mg is indicated in the following cases:

  • Treatment on mild acne to fits a lot of acne, acne and pus acne.

    Acne treatment.

    ATC code: D10AD53.

    adapalen

    Adapalen is a retinoid compound that has been shown to have anti -inflammatory activity in vivo and in vitro. Adapalen is sustainable with oxygen and light and has no chemical reaction. The mechanism of action of Adapalen, like tretinoin, is to cohesion to the specific retinoic acid receptor of the nucleus, but different tretinoin is not attached to the protein of the receptor in the cytoplasm.

    Adapalen when used on the skin has the effect of decomposing acne and also works on the abnormalities of the process of horny and differentiation of the epidermis. Both of these cases are acne factors. The mechanism of action of adapalen is to normalize the differentiation of epithy cyst cells and thus reducing the formation of acne micro -acne.

    benzoyl peroxid

    Benzoyl Peroxid works to peel off the skin, peeling the horn and antibacterial.

    The antibacterial effect of Benzoyl Peroxid may be due to oxidative activity, which is effective on staphylococcus epidermis and propionibacterium acnes. This effect is very useful on acne, topical form on Benzoyl Peroxid 10% is the most widely used and is the first medicine to treat acne. Benzoyl Peroxid also has the effect of inhibiting the bacterial system on the skin along with reducing the surface of small follicles for about 48 hours from the application of the drug, but a few days later it is clinically shown.

    In case of severe acne, additional use of clindamycin or clarithromycin to inhibit anti -drug bacteria.

    Benzoyl Peroxid is also used to treat fungal skin like Tinea Pedis.

    pharmacokinetics

    adapalen

    In humans, Adapalen is absorbed through poor skin. In clinical trials, the adapalen concentration in plasma is not found at a measured level when used long -term on a wide skin area with acne with analytical sensitivity level of 0.15 ng/mL. Therefore, it is not possible to identify the pharmacokinetic parameters about the bioavailability of adapalen when applying on the skin.

    benzoyl peroxid

    The drug is absorbed by skin about 1.8 mcg/cm2 or 45% of the dose for about 24 hours. The amount of benzoyl peroxid is absorbed will be completely converted into benzoic acid in the skin and are quickly eliminated into the urine. Benzoyl Peroxid is applied on the selected diffusion to the epidermis, then slowly to the dermis.

    • Before taking Gel Azaduo Medisun treats mild to medium acne (15g)

    How to use

    Apply thin layer to the disease after washing and dry, 1 time/day in the evening before going to bed. Avoid gel wire in eyes, lips, mucosa.

    Dosage

    The treatment time is determined by the doctor on the basis of the clinical state of the disease. Clinically improved improvement appears after 1-4 weeks of treatment.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Handling: If the skin scales occur too fast, the erythema or edema occurs, it is necessary to stop the drug. To quickly overcome harmful effects, can cover cold gauze. After the symptoms and the above symptoms have decreased, a lower dosage test may be used if it is thought that the reaction has occurred due to too much use, not allergies.

    In case the patient unfortunately swallowed the wrong drug, the need to monitor and treat the symptoms may be encountered.

    Signs to note and other recommendations of the drug (if any): No report.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    Adapalene and Benzoyl Peroxid

    Frequently encountered 1/100 ≤ ADR

  • Dry skin, red skin in the medication area, burning sensation, skin irritation, red rash, peeling skin.
  • intense itching, redness, burning, swelling, dermatitis.

    • Unknown frequency

  • Feeling of burning pain on the skin, allergic eyelid inflammation.

    Common, 1/100 ≤ ADR

  • Itchy skin, feeling of skin pain, irritation (symptoms related to dermatitis), dry skin, erythema, peeling skin, red irritation skin.
  • skin allergies.

    • Unknown frequency

  • Facial swelling.

    Frequently encountered 1/100 ≤ ADR

  • Itchy skin, the feeling of skin pain, irritation (symptoms related to dermatitis). Dry skin, red rash, peeling skin, red irritation skin.
  • allergies.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Azaduo Medisun 15 mg is contraindicated in the following cases:

  • Hypersensitivity to the ingredients of the drug.
  • Children under 9 years old.

    • Pregnant and lactating women.

    Be cautious when using

    Adapalen and Benzoyl Peroxid

    Avoid contact with eyes, lips, nose angle, mucosa. Do not apply the drug on the cut, scratched, the skin of eczema, sunburned skin. Avoid sunlight and electric light.

    Should guide patients with clear information to avoid early stopping drugs while they should still continue: At first there may be a sense of irritation, this is not due to intolerance or allergies. However, the skin sensitivity should still be tested before taking the drug (apply many times on one side of the skin, for many continuous days). To reduce the minimum of irritation, patients need to follow the following principles:

  • Do not apply the drug if the previous use has been irritated. Treatment, then if there is sun -drying, it is necessary to apply sunscreen. If the irritation seems heavy or intolerant, it should be applied. If the itch is still prolonged, it should stop applying the drug. If accidentally applying the medication on the mucosa (eyes, mouth, nostrils) or eyelids, need to be washed with plenty of water. Do not apply medicine to bleeding or damaged skin.

    • adapalen

    If there is a reaction due to sensitive skin or serious irritation occurs, it is necessary to stop using the drug. If expenditure irritation occurs on the spot, patients only need to reduce the frequency of drug use to reduce symptoms until completely lost.

    Do not put the product on the eyes, mouth, nose corner, nasal mucosa. In case of occurring, it is necessary to rinse with clean water. Do not use drugs on open wounds, sunburned skin or new exfoliating areas. Also do not use the drug if the patient has severe acne or the location of acne affects many other areas of the body.

    Should reduce exposure to sunlight and artificial UV radiation, including exposure lights, while using Adapalen. Patients often have to expose the sun for a long time and those who are sensitive to the sun, should be warned to be cautious. Should use sunscreen products and protective clothing when it is impossible to avoid exposure.

    benzoyl peroxid

    The reaction is very mild, red, and peeling can occur for the first time using this active product. These symptoms are harmless, and will usually disappear about 1 day. In the case of allergic reactions, it is worse, it is necessary to reduce the frequency of using the drug.

    The recommended overdose use does not increase the treatment effect of the drug, but increases the risk of unwanted effects.

    Be careful with the same cases of simultaneous use of different acne treatments, because the risk of resonance with side effects and symptoms in the patient becomes worse.

    Do not put the benzoyl peroxid cord into the eyes, nasal mucosa, mouth. In the case of preparations sticking to the eyes, it is necessary to rinse with water. Also be careful when using preparations for sensitive skin areas.

    The drug also increases sensitivity to sunlight, so it does not expose to the light with strong light intensity and avoid sunlight. In case of mandatory, use sunscreen products and sunscreen tools such as masks, sunscreen ...

    If the product is wired into dyed materials (such as hair, fabric ...) can be faded or discolored.

    Not used on open wounds.

    methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) can cause allergic reactions that may be delayed.

    Propylene glycol can cause skin irritation.

    The ability to drive and operate machinery

    The drug does not affect the ability to drive and operate machinery.

    Pregnancy

    Contraindicated for pregnant women

    Lactation period

    Contraindicated for breastfeeding women.

    Interactively

    Adapalen and Benzoyl Peroxid

    Be cautious when used with products that can cause other irritation, sulfur, resorcinol or salicylic acid.

    Products containing benzoyl peroxid can fade hair and discoloration of the fabric, so it is limited to contact with colored products.

    Do not use benzoyl peroxid when exposed to sunlight or ultraviolet rays. Simultaneous use with sunscreen containing paraaminobenzoic acid will change skin color for a while.

    adapalen

    No reports on interactions may occur when using Adapalen and other drugs. However, with retinoid drugs or drugs with the same mechanism of action, it should not be used simultaneously with Adapalen.

    Adapalen is stable with oxygen, light and chemical reactions. Although there is no reporting data on increased sensitivity to the safety of adapalen on humans and animals, it is still advisable to avoid exposure to strong intensity or UV rays.

    benzoyl peroxid

    There is no report on drug interaction. However, drugs have irritating, irritating and drying effects not used simultaneously with Benzoyl Peroxid.

    Storage

    Store in closed packaging, avoid moisture, avoid light, at temperatures below 30 ° C.

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