Gel Vertucid Yash Medicare to treat mild to medium acne (15g)

Dosage form Tube x 15g
Specifications Clindamycin, Adapalene

Ingredient

Composition information	Content
Clindamycin	150mg
Adapalene	15mg

Uses

indications

Vertucid drugs are indicated in the following case:

Treatment of acne skin mild to moderate to moderate with many acne with nucleus, acne and acne. The drug is best used for acne floating on the face, chest or back on dry and flat skin.

Pharmacological

Adapalen is an active ingredient like retinoids that have anti -inflammatory effects on Vivo and In vitro. Adapalen is basically durable with oxygen, light. Adapalen has a tretioin -like mechanism that is connected to a specialized receptor for retinoic acid in the nucleus, but unlike tretionin is not attached to the protein conclusion receptor in the cytoplasm.

Adapalen applied on the skin to treat acne on the mouse model and act on the abnormality of the keratinization process and the epidermal differentiation, both of these processes are the cause of acne. The impact of Adapalen is thought to be the process of normalizing the differentiation of epithelial cell follicles, resulting in reducing the formation of acne core.

Adapalen is better than retinoid reference substances in the testing test of standard anti -inflammatory properties both on vivo and in vitro. The chemical inhibitor and chemicals of polygamy white blood cells and arachidonic acid lipoxid chemical mechanisms into inflammatory intermediaries. This study proposes that the ingredient that causes inflammation through the cell intermediate of acne can be changed by Adapalen.

Clindamycin is the Lincosamid antibiotic group with an aerobic antibacterial activity and anaerobic bacteria. Lincosamid as well as clindamycin associated with 50S of bacterial ribosom and early inhibition of protein synthesis. The effect of clindamycin is mainly bactericidal but at high concentrations can slow down bacteria for sensitive bacteria strains.

Most gram -negative aerobic bacteria include Enerobacteriaceae resistant to clindamycin. Clindamycin is indicated that there is cross resistance to Lincomycin. While in vitro testing, several staphylococcus strains of natural resistance with erythromycin developed rapid resistance to clindamycin.

Dynamic pharmacokinetics

Absorbing adapalen through the skin is low, after applying Adapalen to the wide skin with acne for a long time in clinical trial, the level of adapalen in plasma is not detected with analytical sensitivity of 0.15 µg/ml.

Inactive biological substances Clindamycin phosphate are hydrolyzed into clindamycin. When equivalent to 300 mg of clindamycin is intramuscularly, the peak of the peak in plasma is reached 6 µg/ ml for three hours; 600 mg achieved the peak concentration of 9 µg/ ml. In children, the peak concentration can be achieved within an hour. When the same dose is intravenously, the peak concentration is 7 and 10 µg/ ml and is achieved at the end of the transmission phase.

Clindamycin is widely distributed in body fluids and tissues including bone, but not achieved in cerebrospinal fluid at significant concentrations. The drug diffuses through the placenta during the fetal circulation and appears in breast milk. High concentration in bile. The drug is accumulated in leukocytes and macrophages. More than 90% of clindamycin during circulation are bound to plasma proteins. The sale time is 2-3 hours, but it can last in premature infants and patients with severe renal impairment.

Before taking Gel Vertucid Yash Medicare to treat mild to medium acne (15g)

How to use

use on the skin.

Before applying the medication, you need to wash the acne -prone skin, dry. Use your fingers to apply a thin layer of gel to the skin, away from the eyes and lips.

Dosage

Adults and children over 12 years:

Vertucid is used for acne -prone skin once a day before bed.

When using the drug regularly or alternating to treat acne, consult a doctor to continue to maintain the use of vertucid for patients lasting for more than 3 months.

Patients need to reduce the degree of regular use of drugs or temporarily stop treatment that can re -use medication or continue treatment when the doctor assesses the patient may tolerate the drug.

If the patient uses cosmetics, choose the type without acne and do not have skin astringent.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If applying too much, it does not work faster or better and reduces the skin, peels off the skin or has an unpleasant reaction.

acute dose of toxic Vertucid on rats more than 10 mg/ kg. However, unexpectedly swallowing a small amount of medicine, the method of gastric lavage needs to be considered.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Vertucid, you may experience unwanted effects (ADR).

Agency system

Level

Unwanted effects

skin and skin tissue

Variable street (1/100 -

dry skin, skin irritation, skin burns, increase skin sensitivity, skin red

(1/1000 -

Dermatitis contacts, skin discomfort, sunburn, itching, peeling, acne.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Patients with a history of allergies to clindamycin, lincomycin or any ingredients of the drug (excipients: carbomer-940; phenoxyethanol, isopropyl alcohol, imidurea, propylene glycol, sodium hydroxide;).

Be cautious when used

When using the drug if there is a sensitive reaction or serious irritation, should stop the drug immediately. If in place, patients should not take the drug regularly, temporarily stop or should not continue to use. Vertucid is not exposed to the eyes, mouth, nostrils or mucosa.

If the drug is in the eye, wash immediately with warm water. The drug is not applied to scratched skin, eczema skin. The drug is not used for people with severe acne, acne area spread throughout the body.

When exposed to sun or contact with artificial UV, it is recommended to use Vertucid for a minimum time. Patients must be exposed to sunlight with high intensity or those who are naturally sensitive to sunlight should be careful when using the drug. Recommendation to use products to avoid sun and protective clothes for the skin during the use of the drug.

The ability to drive and operate machinery

The drug does not affect the ability of the car and operating machinery.

Pregnancy

There is no information on the effects of Vertucid in pregnant women, so the drug is not used during pregnancy.

If pregnant during the use of the drug, stop use immediately.

Breastfeeding period

There is no information on drug information whether it is secreted in animal milk or human milk or not.

Avoid using drugs in breastfeeding women but in case of need to use, avoid contacting the drug with children, avoid applying the medicine on the chest.

Drug interaction

There is no knowing that there is an interaction between other preparations used on the skin at the same time as Vertucid. However, retinoids and preparations should not be used at the same time as the drug.

Specific drugs

Drugs

Interactive

Warning

Can increase the effect

Take enough time to reduce the effects of these drugs before starting Adapalen

Contains light sensitivity (such as fluoroquinolon, phenothiazin, sulfonamid, diabetes Thiazid)

Can increase light toxicity

Avoid simultaneous use

Hidden pharmaceutical interactions (increase skin irritation). Avoid using high concentrations of alcohol, peppermint oil, spice, or lime (for example, washing water, skin astringent, perfume); Cosmetics are irritated (for example, ribbon, peeling [flaking]); permanent bending solution; or medicine to hair hair or wax.

Storage

Store in a cool dry place, avoid light, the temperature does not exceed 30 ° C, to be out of reach of children.

Other drugs

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