Gemfibstad 300 Stella medicine for hyperlipidemia (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Gemfibrozil

Ingredient

Composition information	Content
Gemfibrozil	300mg

Uses

indications

Aronatboston drugs are indicated in the following cases:

Gemfibrozil is a selective drug to treat hyperlipidemia, Apoe2/APOE2. Increasing medium and severe blood triglycerides are at risk of pancreatitis. Increasing combined blood lipids, with high VLDL concentration; If the LDL concentration is high, it is indicated to use the low -dose HMG HMG inhibitors. Low cholesterol, LDL - cholesterol increased and triglycerides increased. Gemfibrozil does not work with hyperlipidemia. Gemfibrozil reduces lipoprotein levels rich in triglycerides, such as VLDL (Lipoprotein very low density), slightly increasing HDL levels (high density lipoprotein) and has different effects on LDL (low -density lipoprotein). Effects on VLDL levels may be mainly due to increased activity of lipoprotein lipase, especially in the muscle, leading to increased hydrolysis of triglycerides in VLDL and increased catabolic VLDL. Gemfibrozil also changes the composition of VLDL due to reducing the production of APOC - LLL is the active inhibitor of lipoprotein lipase, and also reduces the synthesis of triglycerides in VLDL in the liver.

Along with the effect on blood lipids, Gemfibrozil also has the effect of reducing platelet aggregation, so it reduces the risk of cardiovascular disease.

The clinical effect of gemfibrozil or any other fibric acid drug on lipoprotein concentration depends on the initial condition of lipoprotein depending on the increase or no increase in lipoprotein. APOE2/APOE2 homozygous blood lipiders respond to the best response to Gemfibrozil therapy. High concentrations of triglycerides and cholesterol may decrease sharply, and yellow tumors with multiple lumps and yellow tumors of hands can be completely reduced. Also works well on angina and horizontal bustling.

Gemfibrozil therapy in mild hyperlly hyperemia (eg triglyceride

Dynamic pharmacokinetics

gemfibrozil is absorbed quickly and much (bioavailability: 98 ± 1%) when taken at meals, but worse if you drink when you are hungry. Achieving plasma peaks within 2 to 4 hours. More than 97% Gemfibrozil is attached to plasma proteins.

Sell waste time is 1.1 ± 0.2 hours. The drug is widely distributed and concentration in the liver, kidneys and intestines is higher than the plasma concentration.

DISTRIBUTION: 0.14 ± 0.03 liters/kg. Gemfibrozil excreted mainly in the form of glucuronid complex; 60 to 90% of oral dose is excreted in urine, and smaller in feces. The gemfibrozil excretion in renal failure has decreased, but less than other fibrats. The clearance: 1.7 ± 0.4 ml/min/kg.

Before taking Gemfibstad 300 Stella medicine for hyperlipidemia (6 blisters x 10 tablets)

How to use

oral medication, drink before breakfast and afternoon 30 minutes.

Dosage

The common dose for adults is 600 mg twice a day.

Must stop the drug after 3 months if the serum lipoprotein level is not significantly good.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Symptoms of overdose include abdominal pain, diarrhea, nausea, vomiting.

How to handle

Extracting Gemfibrozil overdose includes symptomatic and supportive treatment. In case of gemfibrozil overdose, the stomach must be cleaned immediately by causing vomiting or gastric lavage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Gemfibstad 300, you may experience unwanted effects (ADR).

Side effects of Gemfibrozil are generally seen and light, however, because there are similarities in chemical, pharmacological and clinical with clofibrat, Gemfibrozil may have the same side effects as clofibrat. The common side effects of Gemfibrozil in the gastrointestinal tract are sometimes quite heavy that they have to stop the drug.

Common

Digestive: indigestion, abdominal pain, diarrhea, nausea, vomiting, constipation, acute appendicitis.

liver: gallstones.

Central nervous system: fatigue, dizziness, headache. DA: Eczema, Ban.

Uncommon:

Cardiovascular: Atrial fibrillation.

Central nervous system: Increase, dizziness, drowsiness, drowsiness, depression. digestion: flatulence.

Neurological, muscular and bone: Perception.

eyes: blurred vision.

Instructions on how to handle ADR

If you forget to take a dose, use it as soon as possible when remembering. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Gemfibstad 300 drug is contraindicated in the following cases:

Hypersensitivity to gemfibrozil or any ingredients of the drug (excipients: microcrystallin cellulose, sodium glycolat starch, hydroxypropyl cellulose, polysorbat 80, anhydrous collica, talica, magnesium, magnesium stearate.

Kidney or liver dysfunction, gallbladder disease, primary bile cirrhosis.

Do not use gemfibrozil for pregnant women and children.

Caution when using

Start treatment:

Do tests to make sure the lipid concentration is really abnormal. Before conducting treatment with gemfibrozil, serum lipid control must be controlled by appropriate diet, exercise, weight loss in obese people, and other diseases such as diabetes and thyroid reduction are contributing to lipid abnormalities.

During treatment:

Periodically test serum lipid, and stop the drug if poor effect on lipid after 3 months of treatment.

When stopping Gemfibrozil:

It is necessary to have appropriate serum lipid diet and serum lipid monitoring until the patient is stable, because the concentration of triglycerides and serum cholesterol may rise again.

Digestive side effects may need to stop using gemfibrozil. When the patient is using Gemfibrozil, there is a manifestation of muscle pain, touching pain, or muscle weakness, it is necessary to assess muscle inflammation; Through determining the concentration of creatin kinase. If suspected or diagnosed with muscle inflammation must stop taking gemfibrozil.

If you see gallstones, stop using gemfibrozil.

The ability to drive and operate machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. A few rare cases such as dizziness, dizziness affecting the ability to drive.

pregnancy

gemfibrozil through placenta. There is no adequate and verified research project to use gemfibrozil for pregnant women; Do not use gemfibrozil during pregnancy.

Breastfeeding period

It is unknown whether Gemfibrozil is distributed into breast milk or not. Because Gemfibrozil has the ability to cause serious side effects on breastfeeding, breastfeeding should be avoided.

Interactive drug

anticoagulants, Coumarin or indandion:

Simultaneous use with Gemfibrozil can significantly increase the anticoagulant effect of these drugs; Must adjust the anticoagulant dose based on regular prothrombin tests.

chenodesoxxolique or ursodesoxxolique:

The effect can be reduced when using these drugs with Gemfibrozil, which tends to increase cholesterol saturated in bile.

lovastatin:

Concentrated with Gemfibrozil may increase the risk of muscle pattern; significantly increased the level of creatin kinase, and the ureter Myoglobin leads to acute renal failure; It is possible to detect after 3 weeks and late 1 month after the beginning of coordination therapy; Tracking Creatin Kinase cannot prevent severe muscle disease or kidney damage.

Storage

In closed packaging, dry place, avoid moisture. The temperature does not exceed 30 ° C. To be out of reach of children.

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