Gentameson Medipharco skin cream for skin inflammation (10g)

Dosage form Box
Specifications Gentamicin, betamethasone dipropionate, clotrimazol

Ingredient

Composition information	Content
Gentamicin	10mg
Betamethasone dipropionate	6.4mg
Clotrimazol	100mg

Uses

Indications

Gentameson skin cream used for treatment in cases of skin inflammation due to allergies when there is secondary infection:

Psoriasis, contact dermatitis, neuritis, eczema with or without superinfection, sun -caused dermatitis, sexual itching. Learning

betamethason dipropionate

is a corticosteroidal anti -inflammatory, anti -itching and vasoconstriction effect used to treat skin diseases that respond to corticosteroids.

Clotrimazol

is a broad -spectrum antifungal drug used to treat skin -caused skin cases caused by various diseases and also work on trichomonas, staphylococcus and bacteroides. No effect on lactobacilli.

The mechanism of acting of clotrimazol is to link with phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances leading to the destruction of mushroom cells.

gentamicin sulfate

is aminoglycoside antibiotic, the drug has a bactericidal effect through inhibiting bacterial protein biosynthesis. The actual gentamicin antibacterial spectrum includes Gram -negative aerobic bacteria and staphylococcus aureus, including strains producing penicillinase and methicillin resistance.

Gentamicin is less effective for gonorrhea, streptococcal, steering cells, meningococcal brain, citrobacter, Providencia and Enterococci. The mandatory anaerobic bacteria such as Bacteroides, Clostridia are all resistant to Gentamicin.

Gentamicin still works with H.influenzae, Shigella Flexneri, Staphylococcus aureus, S. Epidermidis Special Staphylococcus Saprophyticus, Samonella Typhi and E. Coli

pharmacokinetics

betamethason

Easy to be absorbed when used on the spot. When applied, especially if the skin is closed or when the skin is torn, the amount of betamethasone can be absorbed enough for the whole body.

betamethason is quickly distributed into all tissues in the body.

Medicines through the placenta and can be exported to breast milk in small amounts.

Metabolizes mainly in the liver but also in the kidneys, the lesson is exported to the urine.

Clotrimazol

Apply to the skin is very little absorbed. Six hours after applying 1% Clotrimazol on the skin intact and on the skin of acute inflammation, Clotrimazol levels vary from 100 micrograms/cm3 in the horn layer to 0.5 - 1 microgram/cm3 in spikes and 0.1 micrograms/cm3 in subcutaneous tissue layer.

gentamicin sulfate

Do not absorb through the gastrointestinal tract, the drug is less attached to plasma proteins. Gentamicin diffuses mainly on extracellular fluids and diffuse easily into foreign services. Half of the lives of Genitarnicin from 2-3 hours but can last for infants and kidney failure. Gentamicin is not metabolized and eliminated (almost unchanged) into urine through the glomerular filter.

Before taking Gentameson Medipharco skin cream for skin inflammation (10g)

How to use

Apply a thin layer of cream to the sick area.

Dosage

Apply drugs twice a day in the morning and evening until the injury is improved. If there is no clinical improvement after 3 to 4 weeks should stop the drug and review the diagnosis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

using over -spot corticoide can inhibit the pituitary -adrenal function, which leads to secondary adrenal energy and gives manifestations of adrenal secretion, including Cushing disease.

Use Clotrimazol almost no overdose when used on the spot.

using too much or prolonged gentamicin or prolonged can be added to the growth due to the growth of uncertainty bacteria.

Treatment:

The appropriate symptomatic treatment method is specified. Symptoms of acute adrenal secretion are usually recovered. Adjust the electrolyte imbalance if necessary. In the case of chronic poisoning, the drug should be stopped slowly.

If the growth growth of non -sensitive bacteria, stop using drugs and apply appropriate treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Gentameson skin cream is often experienced unwanted effects (ADR) such as:

On -site: burning, itching, irritation, dry skin, skin atrophy, folliculitis, hair, acne -like rash, dermatitis around the mouth, atopic dermatitis due to contact, skin peeling, skin pattern. Unwanted use when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Gentameson skin cream is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug: corticosteroid, clotrimazol, gentamicin.

Not for pregnant and lactating women.

Be cautious when using

If there is a phenomenon of non -tolerance on the spot to stop treatment.

Only use on the skin, not apply to the eyes and skin around the eyes, to avoid widespread medication, open wounds or damaged skin, do not take the medication for a long time and wound the wound, especially in children and babies.

If there is signs of spreading infection, coordination with body antibiotics.

The effect of drugs on driving and operating machinery

does not affect.

Using drugs for women during pregnancy and lactation

should not be used in pregnant women and nursing women.

Drug interaction

with high doses of paracetamol or acting fields will increase the risk of liver toxicity.

with oral oral diabetes or insulin drugs; Can increase blood glucose levels.

with glycosid digitalis; Can increase the possibility of arrhythmia or toxicity of digitalis accompanied by hypotension.

With phenobarbiton, phenytoin, rifampicin or ephedrin may increase metabolism and reduce the treatment effect of betamethason.

With anti -copper cumarin medications can increase or decrease in copper.

With kidney toxic drugs including other Arninoglycozids, Vancomycin, some cephalosporin medications or with relatively toxic drugs with hearing organs such as ethacrynic acid, furosemid ... will increase the risk of toxicity.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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