Gentamicin Kabi 80 mg/2ml Fresenius Kabi treatments for infections (100 tubes)

Dosage form 100 tube box
Specifications Gentamicin

Ingredient

Thành phần cho 2ml

Composition information	Content
Gentamicin	80mg

Uses

indications

Gentamicin Kabi 80 mg/2 ml is indicated in the following cases:

Gentamicin is often used in combination with other antibiotics (beta - lactam) to treat serious bacterial infections caused by Gram -negative bacteria and other sensitive bacteria, including: bile infection, Brucella infection, viscous dance, endocarditis, blood infection, Listeria infection, meningitis, bacteria, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints, joints The infections of the urinary tract, preventing infections during surgery and in the treatment of immunodeficiency patients.

Gentamicin is often used with other bactericidal substances such as penicillin, metronidazol or clindamycin to expand the spectrum and increase the effectiveness of treatment. Aminoglycoside are taken up to cells by an active transport process, which is inhibited in anaerobic, acidic and highly osmotic environment.

Inside the cell, aminoglyeosides are linked to 30s subunit, or partly with a bacterial ribosom subunit unit, inhibit protein synthesis and create errors in genetic code transcription. The way to kill cells has not been fully understood, and other mechanisms, such as the effect of the absorbent of the cell membrane, can also contribute.

The actual gentamicin antibacterial spectrum consists of Gram -negative aerobic bacteria and staphylococcus aureus, including strains producing penicillinase and methicillin resistance. Gentamicin has little effect on gonorrhea, streptococcal, steering cells, meningococcal brain, citrobacter, Providencia and Enterococci. Mandatory anaerobic bacteria such as BaCleroides, Clostridia are all resistant to Gentamicin. In Vietnam, the strains of E. Aerogenes, Klebsiella Pneumoniae, blue pus bacillus are all resistant to Gentamicin. Gentamicin still works with H. Influenzae, Shigella Flexneri, Staphylococcus aureus, S. Epidermidis Special Staphylococcus Saprophyticus, Salmonella Typhi and E.coli.

Dynamic pharmacokinetics

Gentamicin absorbed mainly through intravenously or intramuscularly. The drug is less attached to plasma proteins, diffusing mainly on extracellular fluids and diffuses easily into the inner ear fluid. The half -life of Gentamicin plasma from 2-3 hours. Gentamicin is not metabolized and eliminated (almost unchanged) into urine through the glomerular filter.

Before taking Gentamicin Kabi 80 mg/2ml Fresenius Kabi treatments for infections (100 tubes)

How to use

intravenous intravenous injection or constant intravenous injection.

Dosage

In case of intravenous infusion, Gentamicin phase with sodium chloride solution or isothermic glucose in the ratio of 1 ml of transmission for 1 mg of Gentamicin. The transmission time lasts from 30 - 60 minutes. For patients with normal kidney function, every 8 hours; In people with kidney failure, the gap is longer.

In patients with normal kidney function

Adults: 3 mg/kg/day, divided into 2-3 intramuscular times.

Children: 3 mg/kg/day, divided into 3 intramuscular times.

Patients with kidney failure

Need to adjust the dosage, regular monitoring of kidney function, snail function and vestibular function. Should be used under the guidance of the physician. Treatment lasts more than 7 - 10 days should quantify the gentamicin concentration in plasma.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Gentamicin Kabi 80 mg/2 ml, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Infinite poisoning and due to the accumulation of the earlobe and the vestibular system (dizziness, dizziness).

Uncommon, 1/1000

Recovery of renal toxicity, acute renal failure, kidney necrosis or interstitial nephritis, inhibiting muscle neurotransmitter. Injected in the conjunctiva causes pain, congestion and conjunctiva. Injection in the eyes causes ischemia in the retina.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Gentamicin Kabi 80 mg/2 ml contraindicated in the following cases:

Patients with allergies to the composition of the drug and with aminoglycosides.

Pregnant women, nursing women.

Be cautious when using

all aminoglycosides are toxic to hearing and kidney. It is necessary to follow very carefully for patients with high doses, long -term, children, elderly people, kidney failure, patients with mechanical weakness, Parkinson's or muscle weakness. The risk of kidney toxicity is seen in people with hypotension, or having liver or women.

The ability to drive and operate machinery

Do not use drugs when driving and operating machinery.

Pregnancy

Do not take medicine for pregnant women.

Breastfeeding period

Do not take medicine for breastfeeding women.

Drug interaction

used with other aminoglycosides, vancomycin and cephalosporin toxic to the kidneys.

Use with ethacrynic acid, Furosemid, and drugs that inhibit neurotransmitter neurotransmites, increasing the risk of toxicity for hearing organs.

Used with indomethacin may increase plasma concentrations of aminoglycosides.

Used with anti -vomiting drugs such as dimenhydrinat can cover the first symptoms of vestibular poisoning.

Storage

Avoid light, temperature not exceeding 30 ° C.

Do not use overdue drugs printed on labels. If the drug solution is detected or cloudy, it is not used.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.