Gentrisone Shinpoong Deawoo Cream Treatment of Skin Fungal, Reducing Skin Pressure (10g)

Dosage form Tube
Specifications Gentamicin, betamethasone dipropionate, clotrimazole

Ingredient

Composition information	Content
Gentamicin	10mg
Betamethasone dipropionate	6.4mg
Clotrimazole	100mg

Uses

Indications

Gentrisone is indicated in cases of atopic dermatitis with infections, fungal infections:

Reduces inflammatory and itching of dermatitis and skin allergies to respond to corticosteroids: Acute and chronic eczema, contact dermatitis, atopic dermatitis, seborrheic dermatitis, chronic flat, scales, psoriasis, psoriasis, anal itching, vulva, minor burns or insect burner. Furfu. Treatment of stem (squint, ringworm), inguinal mushrooms and fungus fungus is trichophyton rubrum, t.mentagrophytes, epidermophyton floccosum, or microsporum canis. Drugs for skin diseases.

Code ATC: D07AC01 (Betamethasone), D01AC01 (Clotrimazol), D06AX07 (Gentamicin).

Medicines containing betamethason, a glucocorticoid with common properties of corticosteroids, clotrimazol antifungal group imidazol and gentamicin antibiotic antibiotic a glucocorticoid carrier aminoglycoside.

local corticosteroids are effective in the treatment of many skin diseases due to anti -inflammatory, anti -itching and vasoconstriction.

Clotrimazol has an anti -fungal effect due to the inhibition of Ergosterol biosynthesis. The inhibition of Ergosterol biosynthesis leads to the decline in the structure and function of the cytoplasm of the fungus. Clotrimazol has a wide antifungal spectrum, including skin diseases, yeast, mold, etc. Clotrimazol also has an impact on Streptococci, Staphylococci, Gardnerella Vaginalis and Bacteroides.

Gentamicin has a few effects on the cells of sensitive bacteria. The drug affects the integrity of the cell membrane and the metabolism of the RNA, but most importantly, the inhibition of protein biosynthesis in the 30s ribosome position. Gentamicin sensitive strains include sensitive streptococcus strains (alpha hemolysis and group A), staphylococcus aureus (positive or negative coagulase, and some parameters penicillinase), and gram -negative bacteria, pseudomonas aeruginosa, aerobacter Aerogenes, Escherichia coileripia coilerichia, prot from the prototu Vulgaris, and Klebsiella Pneumoniae.

pharmacokinetics

Gentrisone 10g drug used in the treatment of skin diseases and used for topical application. Therefore pharmacokinetics related to the bioavailability of the drug in the position of very little impact.

Clotrimazol is distributed into the epidermis after applying on the spot but the absorption in the overall circulation (if any) is very small.

The level of skin absorption of local corticosteroids depends on many factors, including the gills, the integrity of the skin and the tape. Located corticosteroids when absorbed in the overall circulation will connect with plasma proteins and be metabolized in the liver and excreted through the kidneys. Some corticosteroids and metabolites are also excreted through bile.

Before taking Gentrisone Shinpoong Deawoo Cream Treatment of Skin Fungal, Reducing Skin Pressure (10g)

How to use

apply a small amount of Gentrisone cream to the area of injury one or several times a day.

Dosage

Apply a thin layer of cream and rub gently on the damaged skin 2 times/day.

The duration of treatment depends on the degree and position of the disease, response of the patient. If there is no clinical improvement after 1-2 weeks of using the drug, it should be diagnosed again.

Non -ice -covered skin is damaged when taking the drug.

Do not apply medicine to the eye.

If you use medicine for children, do not take more than 5 days in any position on the body.

Do not apply more than 5 days on the face, folded skin areas (such as knees in the knee) or on a wide skin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? In this case, symptomatic treatment should be applied.

Poisoning is also almost no occurrence when accidentally swallowed. The signs of poisoning appears after accidentally swallowing the drug should be treated symptoms.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Gentrisone, you may experience unwanted effects.

burning and stinging, rash, edema, paresthesia and other types of infections on the skin.

Red, blistering, peeling, itching, urticaria, irritated skin, dry skin, folliculitis, hair, acne, dull or pale skin, dermatitis around the mouth, skin allergic reactions, skin, skin atrophy, scratches and skin, bruises, blurred and sensitive.

In children: inhibit the hypothalamus - pituitary - adrenal gland (HPA), Cushing syndrome and increased intracranial pressure.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using Gentrisone 10g, you need to read the instructions carefully and refer to the information below.

Contraindicated

Gentrisone drugs are contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug, with other corticosteroids or imidazols.

Viral infections such as herpes simplex, shingles (shingles), chicken pox, infectious sprouts (molluscum contagiosum), warts, measles and rubella, hand -foot disease - foot - mouth ...

TB skin, syphilis, Behcet disease.

Burns of two or more.

Caution when using

Systemic and local toxicity often occurs, especially when taking the drug extended on an area of deep and wide damaged skin, on the folded or bent skin area. If you use medication for children or when applied to the face, it is best to use only for 5 days. Avoid prolonged medication in all patients, regardless of age.

Local used corticosteroids can cause some disadvantages when treating psoriasis (recurrent recurrence due to increased tolerance, risk of developing pseuding psoriasis, systemic or local toxicity due to impaired skin protection function). Need to monitor carefully.

The absorption of locally used corticosteroids can cause reversible inhibition of the hypothalamus - pituitary - adrenal gland (HPA), causing glucocorticosteroid deficiency after treatment. Cushing syndrome can also occur. Periodic monitoring signs of HPA axis inhibitors in patients with strong steroids with high doses and applied on a wide skin. If the HPA axis inhibitors occur, it is recommended to stop the drug, reduce the number of drugs or replace it with a weaker corticosteroid. The HPA shaft function usually recovers immediately and completely after the drug is stopped. Occasionally, the signs and symptoms of steroid stops may occur, the addition of systemic corticosteroids.

visual disorders may occur when using topical corticosteroids (including rectal, nasal or eye line) or systemic lines. If the patient has symptoms such as blurred vision or other visual disorders, it is advisable to see a specialist to evaluate the cause, may be due to cataracts, glaucom or rare diseases such as Central Serous Chorioretinopathy (CSCR), which appears after taking local corticosteroids or systemic sugars.

All side effects of systemic corticosteroids, including adrenal inhibition, may occur when using local corticosteroids, especially in infants and children.

Children are often more sensitive to body toxicity than adults due to the greater ratio of skin and gravity. Manifestations of adrenal inhibition in young children include L underdevelopment, slow weight gain, plasma cortisol levels and non -response to ACTH stimuli. The manifestation of increased intracranial pressure includes fontanel, enlarged headache and visual enemies on both sides.

Experience in using drugs for children under 12 years of age is limited.

This drug contains propylparaben and methylparaben so it can cause allergic reactions that may appear slowly.

The ability to drive and operate machinery

The drug has almost no effect on driving and operating machinery.

Pregnancy

There is no complete evidence of the safety of the drug during pregnancy.

Clotrimazol does not cause teratogenicity in animals but can be toxic to the fetus when taking high doses.

Local corticosteroids on pregnant animals can cause abnormal fetal development, including cleft palate and growth retardation. Therefore, there may be very small risks of these effects in the fetus. Therefore, this medication should only be used during pregnancy if the benefits of the drug are greater than the potential risk for the fetus and if they have to take the drug, they should not be used as much as applying a large amount of drugs or for a long time.

Breastfeeding period

It is unclear whether the ingredients of the drug will excrete in human milk. Therefore, be cautious when taking medicine for breastfeeding mothers.

Drug interaction

There is no study of drug interaction.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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