Gentusi Ltd Farmaprim Treatment Treatment of vaginal mixture (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Metronidazole, chloramphenicol, nystatin, dexamethasone acetate

Ingredient

Composition information	Content
Metronidazole	225mg
Chloramphenicol	100mg
Nystatin	75mg
Dexamethasone acetate	0.5mg

Uses

Indications

mixed bacterial infections in the vagina, vaginitis accompanied by white blood, itching caused by bacterial and fungal, vaginitis caused by trichomonas, vaginitis due to mixed causes, preventing vaginal yeast infections.

Pharmacology

Gentust has a formula that combines many compounds, thus having the effect of local vaginitis due to various causes such as fungal infections, bacterial infections, parasites or many pathogens at the same time.

The drug is coordinated:

metronidazole:

Metronidazole is a substance with a wide bacterial activity street on protozoa such as: Amip, Giardia Lamblia. And in anaerobic bacteria. Metronidazole has bactericidal effects on bacteroides, fusobacterium and other compulsory anaerobic bacteria but does not work on noni bacteria.

Metronidazole is only resistant to a few cases. However, when using Metronidazole alone to treat Campylobacter or H. Pylori, the drug is growing very fast. When infected with both anaerobic and anaerobic bacteria, Metronidazole must be combined with other antibacterial drugs. Trichomonas vaginalis infection can be treated with Metronidazole or localized. Both women and men must be treated, because men can carry pathogens without symptoms. In many cases, it is necessary to treat vaginal drugs and tablets. When bacterial/vaginal inflammation is caused by bacterial/vagina, Metronidazole will cause the vaginal bacteria to return to normal, in the majority of patients taking drugs, Metronidazole does not affect the normal vaginal bacteria.

chloramphenicol: Chloramphenicol is antibiotic, originally isolated from the Venezuelae Streptomyces, which is now produced by synthetic methods. Chloramphenicol often has bactericidal effects, but can kill bacteria at high concentrations or for highly sensitive bacteria.

chloramphenicol inhibits protein synthesis in sensitive bacteria by attaching to the mini of the ribosom 50s. The drug has the same position with Erythromycin, Clindamycin, Lincomycin, Oleandomycin and Troleandomycin.

Chloramphenicol also inhibits protein synthesis in rapid proliferation cells of mammals; Chloramphenicol may cause bone marrow inhibition and may not recover. Chloramphenicol has immunosuppressive activity if the whole body is used before the antigen stimulates the body; However, antibodies may not be significantly affected when using chloramphenicol after antigen.

nystatin:

Nystatin is an anti -fungal antibiotic extracted from streptomyces noursei mushroom culture, yellow powder, very little soluble in water. Nystatin has the effect of restraining or killing fungi depending on the concentration and sensitivity of the fungus, not affecting the bacteria only normal on the body. The most sensitive is yeast and has a very good effect on Candida Albicans.

Mechanism of action: Due to the link with the sterol of the cell membrane sensitive fungi, nystatin changes the absorbent of the mushroom film. Nystatin tolerates well even when long -term treatment and does not cause drug resistance.

dexamethason:

dexamethason is fluomethylprednisolon, synthetic glucocorticoid, almost insoluble in water. The glucocorticoids act on the receptor in the cell, the transfusion into the cell nucleus and there has affected some of the translated genes. Glucocorticoids also have some direct effects, may not be intermediaries connected to the receptor. Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibition, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, dexamethason is 30 times stronger than hydrocortisone, 7 times stronger than prednisolon.

pharmacokinetics

metronidazole

Put a single dose of 5g gel into the vagina (equal to 37.5 mg of metronidazole), the medium serum metronidazole concentration is 237 nanogam/ml. This concentration is about 2 % of Metronidazole concentration maximum average in serum after drinking once 500 mg of metronidazole (the average CMAX is 12,785 nanogam/ml), these peak concentrations reach 6-12 hours after geling in the vagina.

nystatin

Nystatin is not absorbed through the skin or mucosa when used on the spot, excreting mainly through feces in the form of unprover.

dexamethason

dexamethasone as well as corticosteroids are well absorbed at the position of the drug and then distributed into all tissues in the body. The drug through the placenta and a small amount of milk. The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most of the form of non -conjugated steroids. Half a life of plasma is 3.5-4.5 hours, but when it comes to effects, often use half a biological life. The half-life of dexamethasone is 36-54 hours, so the drug is especially suitable for diseases that need glucocorticoid-acting glucocorticoids.

Before taking Gentusi Ltd Farmaprim Treatment Treatment of vaginal mixture (2 blisters x 5 tablets)

How to use

before placing it, put the pill in the freezer for 5-10 minutes, wash the vagina, put deep into the vagina every night before going to bed. To get the best treatment results, use your fingers to push the pills deep as deep as possible.

Dosage

Cases of infections, fungal infections, vaginitis due to mixed causes, placing 1 bullet once a day (before going to bed). The average time of treatment is 10-12 days. When stopping treatment. Nausea, vomiting, diarrhea, dyeing urine (dark due to Metronidazole overdose).
Overdose treatment: Stop medication and symptomatic treatment.
What to do when you forget a dose?

Side Effects

Local reactions (> 1%) include minor burns, irritation, vaginal irritation, vaginal itching. Especially when there is an open damage. Itching is especially at the beginning of treatment, but there is no need to stop treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Hypersensitivity to one of the ingredients of the drug: Hypersensitivity to Metronidazol or other nitroimidazol derivatives, hypersensitivity to nystatin, patients with hypersensitivity and/or toxic reactions caused by chloramphenicol. Hypersensitivity to dexamethasone; Systemic fungal infections, local virus infections or tuberculosis, gonorrhea are not controlled by antibacterial drugs.

Be cautious when using

Avoid having sex during treatment. To prevent re -infection, it is necessary to treat the partner at the same time. After 4 weeks of treatment, if not supported again.

avoid sources of infection or re -infection.

The effect of the drug on the ability to drive and operate machinery

No report has affected the ability to drive and operate machinery.

Using drugs for women during pregnancy and lactation

Pregnancy:

The safety of the drug when used for pregnant women has not been established, so it should not be used in this period.

Women who are breastfeeding:

Caution should consider using this period. Should consider stopping breastfeeding when using the drug.

Drug interactions

Sperm kills: Do not coordinate (the risk of disabling the trichomonas killers on the spot contraceptive effect of spermicide).

Do not coordinate with alcohol, disulfirame (causing acute paranoia, and mental).

metronidazol:

Metronidazole increases the effect of anticoagulant oral drugs, especially warfarin, so avoid use at the same time. Therefore, do not simultaneously use these two drugs to avoid nervous effects such as psychosis, confusion. Up, toxic.

chloramphenicol:

Do not simultaneously use chloramphenicol with antibacterial antibiotics, drugs that work on hematopoietic systems, Coumarin, Hytantoin and Methotrexate.

corticosteroid:

Barbiturat, Phenytoin, Rifampicin, Rifabutin, Carbamazepin, Ephedrine, Aminoglutethimide can increase corticosteroid removal, which reduces the treatment effect. Tieu. Corticosteroids, so when corticosteroids are susceptible to salicylate poisoning.

Storage

Store in a cool dry place, avoid light, store at a temperature not exceeding 30 ° C.

Keep the drug out of reach of children.

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