Getzlox 500mg Getz medicine for infections (1 blister x 10 tablets)
Dosage form Box of 1 blister x 10 tablets
Specifications Levofloxacin
Ingredient
| Composition information | Content |
| Levofloxacin | 500mg |
Uses
Indications
Getzlox is indicated to treat adults (≥18 years old) with mild, average to severe infection caused by the sensitive bacteria in the following cases:
levofloxacin is the l-iSomer of ofloxacin antibacterial drugs belonging to the quinolon group. The main antibacterial effect of Ofloxacin is L-Isomer. The main mechanism of levofloxacin is to inhibit the Topoisomerase IV and DNA Gyrase (both of these enzymes are Topoisomerase tube II), necessary for bacterial reproduction.
On-vitro levofloxacin is active against Gram-negative and Gram-positive bacteria. The drug has a bactericidal effect at concentrations equal to or higher than inhibited concentrations. The drug has about 2 times the active active substance of its isomer. ofloxacin.
Relationship PK/PD
The level of antibacterial activity of levofloxacin depends on the ratio between the maximum concentration in plasma (CMAX) or the area under the curved (AUC) and the minimum inhibitory concentration (MIC).
resistance mechanism
Levofloxacin resistance is acquired through the process of continuous transformation of the target position of both Lopoisomerase. DNA Gyrase Topoisomerase IV. Other terrible mechanisms such as osmotic barriers (usually in Pseudomonas Aeruginosa) and full mechanism can also affect the sensitivity of levofloxacin.
The cross -resistance between levofloxacin and some other fluoroquinolon is also recorded. Due to the mechanism of operation, generally there is no cross -resistance between levofloxacin and other antibacterial drugs.
pharmacokinetic
absorption
After drinking, Levofloxacin Pharmacy absorbed quickly and completely with the peak concentration in plasma reached 1-2 hours after taking the drug. Absolute bioavailability is about 99-100%.
Food has very little effect on the absorption capacity of levofloxacin.
Stable state is achieved within 48 hours after taking a dose of 500mg a or twice daily.
distribution
about 30-40% levofloxacin binds to plasma proteins. Levofloxacin's distribution volume is about 1001 after a single dose and a repeated dose of 500mg, showing widely distributed into the body tissue.
penetrates into tissue and body fluid
levofloxacin shows that it can penetrate into the lung mucosa, epithelium mucosa, pulmonary cells, coordinates, skin (blisters), prostate tissue and urine. However, levofloxacin penetrates poorly through cerebrospinal fluid.
Biological metabolism
Levofloxacin metabolizes at a very small level, metabolic substances are desmethyl-levofloxacin and levofloxacin n-oxide. These metabolites are calculated less than 5% of the dose and excreted through the urine. Levofloxacin has stereoscopic chemical stability and is not asymmetrical reversal.
Elimination
After drinking or intravenously. Levolloxacin is eliminated quite slowly from blood (Thai selling time 12: 6 - 8 hours). Pregnancy except mainly through the kidneys (> 85% dose).
Before taking Getzlox 500mg Getz medicine for infections (1 blister x 10 tablets)
How to use
Getzlox Tablets (Levofloxacin) should be swallowed with a medium amount of water, not crushed. The drug can be taken at meals or between two meals.
Getzlox Tablets (Levofloxacin) compression should be used for at least 2 hours before or after taking antacids such as magnesi, aluminum, as well as sucralfate, metal cation such as iron and vitamin skin preparations with zinc or dancanosin/cushion or powder mixed with oral solution for children.
Dosage
Getzlox Tablets (Levofloxacin) tablets use 1 or 2 times daily. Dosage depending on the type and level of infection and sensitivity of the pathogens are suspected.
Dosage for patients with normal renal function (Creatinin clearance> 50ml/minute)
chronic prostatitis 250 mg No need to adjust the dose in elderly patients, except for consideration of kidney function. Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist. The effects on the central nervous system such as status, convulsions, hallucinations and tremor are also recorded during the circulation of the drug. If overdose occurs, symptomatic treatment should be conducted. Monitoring the center (ECC) due to the ability to extend the QT range. Acid resistance should be indicated to protect the stomach lining. Hemorrhage appraisal includes peritoneal and peritoneal fertilizer continuously ineffective in the island of Thai Levofloxacin from the body. No specific antigen. In an emergency, call the 115 emergency center immediately or go to the nearest local health station. What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.
every 24 hours What to do when overdose?
Side Effects
The following unwanted side effects are determined for the active ingredient Levofloxacin. Group by frequency is very common (ADR ≥ 1/10), common (1/100 ≤ ADR ≤ 1/10), rarely (1/1000 ≤ ADR ≤ 1/100), Understanding (1/1000 ≤ ADR ≤ 1/10000) and very rare (ADR
Infections and parasites:
Blood disorders and lymphatic systems:
Disorders of metabolism and nutrition:
Eye disorders:
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Getzlox drugs contraindicated in the following cases:
Precautions when used
serious harmful reactions are likely to not recover and cause disabilities, including tendonitis, tendons, foreign neuropathy and adverse effects on the central nervous system.
Fluoroquinolon antibiotics are associated with serious harmful reactions that are likely to cause disability in different organs of the body.
These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion).
These reactions can occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may have these harmful reactions.
Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions.
In addition, avoiding the use of Flurorquinolon antibiotics for patients who have experienced serious reactions related to fluoroquinolon. S. Aureus is resistant to methicillin, which is very capable of lying against the fluoroquinolon group, including Levofloxacin. Therefore, it is not recommended to treat levofloxacin for patients who know or suspect S. aureus resistant to methicillin if the test results do not determine the sensitivity of bacteria with levofloxacin (and reward antibiotics recommended to treat S. Aureus resistant methicillin.Fluoroquinolon antagonists of E. coli, the most common pathogens that cause urinary tract infections change in the European community. Doctors should consider the incidence of Fluoroquinolon resistance of E. Coli locally.
Treatment of coal diseases
Human use based on the sensitive data of Bacillus anthracis in vitro and animal test data with limited data on humans. When treated, the doctor should consult the national and/or international documents related to the treatment of coal diseases.
muscle inflammation and tendons
Tenditis rarely occurs. Mostly occurs in the tendon of Achile leading to the tendon. Close and close inflammation, sometimes both sides, may occur within 48 hours after the start of the kite with levofloxacin or maybe months after the end of treatment with levofloxacin. The risk of tendonitis and tendon rupture increases in patients over 60 years old, patients use daily doses of 1000mg and for patients who are using corticosteroids.
Adjust the daily dose in older patients based on creatinine clearance. Therefore, it is necessary to close these patients closely if they are indicated for treatment with levofloxacin. Patients should consult a doctor/pharmacist if the symptoms of tendonitis occur. If the tendon is suspected, levofloxacin must be discontinued immediately, and should start appropriate therapy (as fixed) so as not to affect close.
diarrhea caused by Clostridium difficile infection
diarrhea, especially if serious, persistent and/or bleeding, occurs during treatment or after treatment with levofloxacin (including a few weeks after treatment), may be a symptom of the disease related to Clostridium difficile. Diarrhea caused by Clostridium Difficile (CDAD) can be from average to life threatening, the most serious form is fake colitis.
Therefore, it is important to consider this diagnosis in patients with serious diarrhea progression during treatment or after treatment with levofloxacin. If the CDAD is suspected or identified, Levofloxacin should be discontinued immediately and conducted other appropriate treatments not to be delayed. Contraindicated drugs that inhibit peristalsis in these cases.
patients are susceptible to seizures
Quinolon can reduce the seizures threshold and may start the seizures. Levofloxacin in patients with a history of epilepsy, and like other quinolon drugs, especially cautious when using the drug for patients with seizures or simultaneous use with active ingredients that reduce seizures such as theophylllin. In the case of epilepsy seizures, should stop treatment with levofloxacin.
Patients with enamel deficiency G-6-phosphate dehydrogenase
Patients with the ability to be diagnosed with G-6-phosphate dehydrogenase deficiency may occur blood-soluble reactions when treated with quinolon antibiotics. Therefore, if levofloxacin must be used for these patients, the likelihood of hemolysis must be monitored.
Patients with impaired renal function
Because levofloxacin is excreted mainly through the kidneys, the dose adjustment should be adjusted in patients with renal failure.
Hypersensitivity reaction
levofloxacin can cause serious hypersensitivity reactions that can be fatal (such as angiema leading to anaphylactic shock), sometimes after using the oil starting dose. Patients should stop treating immediately, systematic with the doctor for timely emergency measures.
Serious blistering reaction
Cases of serious blistering reactions such as Stevens-Johnson syndrome or poisoned skin necrosis are also recorded with levofloxacin. The patient is advised to consult with the doctor immediately before continuing treatment if the reaction on the skin and/or the concept of the item happened.
Blood glucose disorders
As other quinolons, blood glucose disorders include symptoms of hyperlemen or hypoglycemia. Also recorded in patients with diabetes using levofloxacin simultaneously with hypoglycemic oral medication (such as glibenclamid) or insulin. Some cases of coma due to hypoglycemia have also been recorded. For patients with diabetes recommended to closely monitor blood glucose levels.
sensitive to light
Light sensitive reactions also recorded in patients using levofloxacin. It is recommended that patients do not expose themselves to intense sunlight or artificial UV exposure (such as lighting, sunbathing) during treatment or within 48 hours after stopping treatment to avoid light -sensitive reactions.
Patients with vitamin K anti -vitamin treatments
Due to increased and/or bleeding indicators in patients with Levofloxacin treatment in combination with vitamin K (such as warfarin), blood clotting tests should be monitored when using these drugs simultaneously.
Patients with a history of mental disorders
Mental reaction recorded in patients treated with fluoroquinolon including levofloxacin. In some very rare cases, these patients develop suicide thoughts or dangerous behaviors for themselves, including suicide trying, sometimes occurring after using levofloxacin doses. If the patient progresses these reactions, levofloxacin should be stopped and taken appropriate treatments.
Be cautious when using levofloxacin for patients with a history of mental disorders or patients with mental illness.
extends the range of qt
Should be cautious when using fluoroquinolon, including ofloxacin in patients with risk factors that extend the QT as follows:
Simultaneously used the known drugs that extend the QT range (such as IA and III arrhythmias, 3 -round depression, macrolid and mental disorder).
heart disease (such as heart failure, myocardial infarction, slow heart rate).
peripheral neuropathy
Quan Quan or sensory polygon - motor has also been recorded in patients using fluoroquinolon, including levofloxacin, which can quickly start. Levofloxacin should stop using if the patient has symptoms of neuropathy. This will minimize the risk of developing negative reactions.
Patients with liver function impairment
The case of liver necrosis leads to death from liver failure with levolloxacin, mainly in patients in severe stage, such as infections. Patients are recommended to stop treating and consulting the doctor if the symptoms and signs of the liver disease progresses such as anorexia, jaundice, black urine, itching or abdominal pain.
Severe mechanical diseases
fluoroquinolon, including levofloxacin, has a neurological -muscle blocking activity and can lead to severe muscle weakness in patients with muscle weakness. The serious unwanted effects after circulation include death and support for steaming support, related to the use of fluoroquinolon in severe myasthenia patients. It is recommended not to indicate levofloxacin in patients with a history of muscle weakness.
visual disorders
If the vision is impaired or any effect on the eye occurs. Should consult the vision expert immediately.
superinfection
Like other antibiotics, using levofloxacin, especially prolonged, can lead to the development of non -sensitive bacteria. If secondary superinfection occurs during the treatment process, appropriate measures should be conducted.
Influence on tests
For patients treated with levofloxacin, the opiat concentration test in the urine can give positive results.
It is necessary to determine the positive opiat concentration by specific methods.
levofloxacin can inhibit the growth of mycobacterium tuberculosis and thus can lead to negative results in tuberculosis tests.
Getzlox Tablets 250mg and Getzlox Tablets 500mg: The drug contains Lactose excipients, so patients with rare genetic problems are galactose intolerance, lactase deficiency or glucose-galactose should not be used.
Use drugs for women during pregnancy and lactation
Pregnant women
There are very few data used for pregnant women. Animal studies do not indicate directly or indirect effects on reproductive toxicity.
On the other hand, due to the lack of drug data in pregnant women and due to research data shows the risk of damage by fluoroquinolon to the fetal cartilage of the fetus is developing, contraindicating levofloxacin for pregnant women.breastfeeding women
levofloxacin is contraindicated for nursing women. There is no adequate information on the excretion of levofloxacin into breast milk: However, other drugs belong to the Fluoroquinolon group that is excreted in breast milk. On the other hand, due to lack of drug data in nursing women and due to research data shows the risk of damage by Fluoroquinolon to the fetal cartilage is developing, Levofloxacin is contraindicated for breastfeeding women.
The effect of the drug on the ability to drive and operate machinery
should not drive, operate machinery or other activities that need concentration or alertness because Levofloxacin can cause dizziness and dizziness.
Medicinal interaction
antacids containing magnesi, groups or sucralfate metal elements such as iron and multi -smoothie preparations: simultaneous use of levofloxacin with antacids containing magnesi, aluminum or sucralfate, metal elements such as iron and skin -containing skin products that can hinder the absorption of stomach in the stomach of the stomach Levofloxacin leads to lower drug concentration than expected. Levofloxacin should be taken at least 2 hours before or after taking these drugs.
Theophylllin, fenbufen or nonsteroidal anti -inflammatory drugs: reducing significant seizures may occur when using quinolones simultaneously with theophylllin, nonsteroidal anti -inflammatory drugs or other agents that also lower the seizure threshold.
Levofloxacin concentration is about 13% higher if used with fenbufen compared to individual use.
Probenecid and cimetidine: Be careful when using levofloxacin simultaneously with drugs that influence the elimination of renal tubules such as Probenecid and Cimetidine, especially patients with renal impairment.
Storage
Leave in a dry place, avoid light, the temperature does not exceed 30 degrees C.
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