Getzome 40 Getz treatment for stomach ulcer, duodenum (2 blisters x 7 tablets)
Dosage form Box of 2 blisters x 7 tablets
Specifications Omeprazol
Ingredient
| Composition information | Content |
| Omeprazol | 40mg |
Uses
Indications 2>Getzome 40 drugs are indicated in the following cases:
Adults:
Gastroesophageal reflux disease (GERD) without esophageal injury.
Children 1 year and older and ≥ 10kg:
pharmacokinetics
absorption and distribution
omeprazole is an unstable acid and is taken or taken by oral in the form of melted particles in the intestine in the capsule. Omeprazole absorbs quickly but changes when used by oral, peak concentration in plasma is reached within 0.5 to 3.5 hours. The absorption of omeprazole is not influenced by food. Higher absorption after a long time of medication.
Birth of Omeprazole is about 35%. After repeating the dose 1 time/day, bioavailability increases to about 60%. The ratio of cohesion with plasma protein is about 95%.
Metabolism and excretion
After absorbing Omeprazole is completely metabolized, mainly in the liver. CYP2C19 and CYP3A enzymes catalyzed most of the metabolic process. The metabolites are not active and excreted mostly through the urine and a less amount through the bile. About 77% of the metabolites are excreted in the urine and the rest through the feces. Selling time for plasma is about 0.5 to 3 hours.
Before taking Getzome 40 Getz treatment for stomach ulcer, duodenum (2 blisters x 7 tablets)
How to use
Take oral use.
Dosage
adults
Treatment of duodenal ulcer
The recommended dose in patients with progressive duodenal ulcer is Getzome 20 mg once a day. Most patients heal ulcers within two weeks. For patients who have not healed ulcers completely after the initial treatment, continue the treatment for two more weeks. In patients with poor duodenal ulcer, encourage 40 mg of Getzome once a day and effectively achieved within four weeks.recurrent duodenal ulcerative preventive
Prevention of recurrent duodenal ulcer in negative patients with H.pylori or when it is impossible to eradicate H.pylori, the recommended dose is 20 mg of omeprazole per day. In some patients, the dose of 10 mg may be used. In the event of failure, the dose can be increased to 40 mg.
Treatment of stomach ulcers
The recommended dose is Getzome 20 mg daily. Most patients heal ulcers within 4 weeks. For patients who are not completely cured after the initial treatment, another 4 weeks will help heal the ulcer. In patients with poorly responded ulcers, the recommended dose is 40 mg of Getzome and can heal ulcers within 8 weeks.
Refuensions of stomach ulcers
Prevention of recurrence in patients with poorly responded stomach ulcers, the recommended getzome dose is 20 mg daily. If necessary, the dose can be increased to 40 mg Getzome per day.
H.pylori kill in patients with gastrointestinal ulcer
To kill H.pylori, when choosing antibiotics, it is necessary to consider the patient's tolerance, and must depend on the national, regional and local resistance model and the treatment time as instructed.
Treatment regimen with 3 drugs
Treatment regimen with 2 drugs
Getzome 20 mg twice daily or 40 mg once daily with Clarithromycin 500 mg/3 times a day for 14 days; If the ulcer appears during the beginning of the treatment, it may be necessary to increase the treatment time of Omeprazole 20 mg/day adds 14-18 days (single treatment) after completion of coordination treatment.
Gastroesophageal reflux disease (GERD) has no esophageal injury
Getzome 20 mg/day to 4 weeks.
Treatment of peptic ulcer due to nonsteroidal anti -inflammatory drugs (NSAIDs)
The recommended dose is Getzome 20 mg daily. Most patients heal ulcers within 4 weeks. For patients who do not heal the ulcer completely after initial treatment, often heals ulcers after 4 weeks of treatment.
Peptic ulcer prevention in patients at risk
To prevent stomach ulcers or duodenal ulcers in patients at risk (> 60 years old, with a stomach and duodenal ulcer, with a history of gastrointestinal bleeding), the recommended dose is Getzome 20 mg daily.
Treatment of esophagitis due to reflux
The recommended dose is Getzome 20 mg daily. Most patients heal ulcers within 4 weeks. For patients who do not heal the ulcer completely after initial treatment, often heals ulcers after 4 weeks of treatment.
In patients with severe esophagitis, the recommended dose is 40 mg of Getzome daily and usually heals ulcers for 8 weeks.
Long -term control in patients healed esophagitis due to reflux
The recommended dose is Getzome 10 mg, if necessary, the dose can be increased to 20 - 40 mg daily.
Symptomatic treatment in patients with gastroesophageal reflux
The recommended dose is Getzome 20 mg daily. Patients can respond well for 10 mg daily and thus consider adjusting the dose depending on the patient. If not achieved symptoms after 4 weeks of treatment with 20 mg of Getzome per day, recommendation to be evaluated.
Pathological condition increases secretion
Starting 60 mg/day, the dose increases to 120 mg 3 times/day, daily dose> 80 mg divided into two times.
Continuing heartburn (≥ twice a week)
20 mg/day for 14 days.
Zollinger syndrome - Ellision
Starting dose: 60 mg omeprazole/day. The dose may vary depending on the individual and the clinical aspect of the treatment should be extended sufficiently as directed.
The dose may increase to 80 - 120 mg omeprazole/day, with a dose of over 80 mg/day, the dose should be divided 2 times/day.
Over 90% of patients with serious illness and incomplete response to other therapies can be controlled at a dose of 20 - 120 mg omeprazole per day.
Children
Children from 1 year of age and over 10kg
Treatment of esophagitis due to reflux.
Treatment of heartburn and acid reflux in patients with gastroesophageal reflux disease. The recommended dose is as follows:
age
Weight
Dosage
10 - 20 kg
10 mg per day, can increase to 20 mg per day if necessary.
≥ 2 years old 20 kg
20 mg per day, the dose may increase to 40 mg daily.
Weight
Dosage
15 - 30 kg
Getzome 10 mg combined with amoxicillin 25 mg/kg/body weight and clarithromycin 7.5 mg/kg/body weight, use 2 times/day for 1 week.
31 - 40 kg
Getzome 20 mg combined with amoxicillin 750 mg and clarithromycin 7.5 mg/kg/body weight, use 2 times/for 1 week.
40 kg
Getzome 20 mg combined with amoxicillin 1 g and Clarithromycin 500 mg, used 2 times/day for 1 week.
No dose adjustment in the elderly.
Renal failure
No dose adjustments in patients with renal function.
Prevention of gastric acid inhalation
Omeprazole is also used to prevent gastric acid inhalation during body anesthesia. Take the dose of 40 mg in the evening before surgery and add a dose of 40 mg before surgery 2 - 6 hours.
Liver function failure
Birth and half -life can increase in patients with liver function, so the dose adjustments need to be adjusted, and the maximum dose is 20 mg/day.
Patients with difficulty swallowing
Can pour the medicine in the pupae, swallow separately or share the seeds with a small amount of fruit juice or yogurt after mixing. Can absorb the granules in peanuts and swallow later. It is important not to be crushed or chewed.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do
do when overdose? No serious symptoms occur when using the oral dosage up to 400 mg. The first thing to remove from the body and do not need any specific therapy. What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Getzome 40, you may experience unwanted effects (ADR).
Getzome 40 well tolerated, often light side effects and recovery.
In some cases, the following reactions appear: blurred vision, taste disorders, aggressive, peripheral edema, sodium lower blood, sweating, large breast enlargement in men, helplessness, leukopenia, thrombocytopenia, granulocytosis, reduced blood cells, anaphylactic shock, discomfort, fever, bronchitis, severe hepatitis in the patients with severe hepatitis, some patients with hepatitis, severe hepatitis, some patients with severe hepatitis, some patients with severe hepatitis, some patients with hepatitis Few cases of liver failure and interstitial nephritis then lead to acute nephritis. Liver enzymes also happened. Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
Getzome 40 drugs contraindicated in the following cases:
Be cautious when used
acid in the stomach is reduced in any way, including inhibition of proton pumps can increase the number of permanent bacteria in the stomach, which can lead to a slight increase in the risk of digestive infections such as Salmonella and Campylobacter.
When suspected stomach ulcers, it is necessary to eliminate malignant ability before starting treatment with Getzome, because the treatment can reduce symptoms and delay diagnosis.
The ability to drive and operate machinery
omeprazole does not affect the ability to drive and operate machinery. Side effects of the drug such as dizziness and visual disorders may occur. If affected, patients should not drive or operate machinery.
Pregnancy
There is no evidence of Getzome's safety in pregnant women. Animal studies have shown that there is no teratogenic effect, but have shown that the fetal weight is reduced. Avoid use for pregnant women unless there are no safer measures.
The period of breastfeeding
There is no report showing that Getzome passes through milk or has an influence on babies. If it is necessary to use Getzome, you should stop breastfeeding.
Drug interaction
simultaneously used with omeprazole may reduce the absorption through the stomach of ketoconazole or iTraconazole due to reduced acidic concentration in the stomach.
Omeprazole can delay the elimination of diazepam, phenytoin and warfarin when used simultaneously because Omeprazole metabolizes through the liver through cytochrome P450.
The concentration of omeprazole and clarithromycin in plasma increases when used in combination. This is considered a useful interaction in destroying H. Pylori. There is no evidence of the interaction of omeprazole with phenacetin, theophyllline, caffeine, propranolol, metoprolol, cylosporin, lidocaine, quinidine, estradiol, amoxicillin or antacids. Getzome's absorption is not influenced by alcohol or food.
There is no evidence of interaction with piroxicam, diclofenac or naproxen. This is considered useful when patients need to continue with these treatments.
Simultaneous coordination of omeprazole and digoxin in healthy people leads to 10% increase in digoxin due to increased pH in the stomach.
Storage
Store at temperatures below 30 ° C, avoiding light and moisture.
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