Glazi 250 Abbott treat acute sinusitis, acute otitis media, pharyngitis, tonsillitis (2 blisters x 6 tablets)

Dosage form Box of 2 blisters x 6 tablets
Specifications Azithromycin

Ingredient

Composition information	Content
Azithromycin	250mg

Uses

indications

Glazi 250mg drug is indicated in the treatment of bacterial infections that are sensitive to drugs, including:

Acute sinusitis caused by bacteria. trachomatis.

ATC code: J01FA10.

Azithromycin is an antibiotic that has a broad spectrum of a macrolid group, also known as azalid, used in the treatment of many different types of infections caused by drug sensitive strains. Azithromycin is inversely attached to Ribosom's 50S subunit, which prevents protein synthesis, and thus inhibits bacterial cell growth.

Pathogenic bacteria are often sensitive to azithromycin, including:

Gram -positive bacteria: Streptococcus, Pneumococcus, Staphylococcus aureus. Some other gram -positive bacteria also respond to azithromycin including corynebacterium diphtheriae, Clostridium perfringens, peptostreptoccus and propionibacterium acnes. Moraxella CatVrhalis, Acinetobacter, Yersinia, Legionella Pneumophila, Bordetella Pertussis, and Parapertussis; Neisseria gonorrhoeae and campylobacter sp. Pneumoniae, Treponema Pallidum and Borrelia Burgdorferi. E. Coli, Salmonella Enteritidis and Salmonella Typhi, Entobacter, Aeromonas Hydrophila, Klebsiella less sensitive to azithromycin. stronger on some Gram -negative bacteria including Haemophilus Influenzae.

azithromycin shows cross -resistant strains of resistance to erythromycin, including streptococcus Faecalis (Enterococcus) and most anti -methicillin staphylococci strains.

The commonly anti -Azithromycin grams are Proteus, Serratia, Pseudomonas Aeruginosa and Morganella.

Dynamic pharmacokinetics

Oral bioactivity of azithromycin about 40%. Food reduces the absorption of drugs for capsules but does not reduce the absorption of tablets. The peak concentration of plasma is achieved within 2 to 3 hours. When the meninges are not inflamed, the drug diffuses poorly into the cerebrospinal fluid.

azithromycin is widely distributed throughout the tissue in the body, and the concentration of tissue is higher than in the blood.

Azithromycin is small, methyl is reduced in the liver, excreted in bile in a constant form and partly in the form of metabolism. About 6% of oral dosage except for urine. Selling time is about 68 hours.

Pharmacokinetics in special subjects

Patients with impaired renal function: After using a single dose of 1g azithromycin, CMAX and AUC0-120 concentration increases to 5.1% and 4.2%, the results obtained from a comparative study in a group of patients with medium and mild renal failure (glomerular filtration rate is about 10 - 80 ml/min) with a group with normal kidney function (GFR> 80 mL/minute). In patients with severe renal failure, the average value of CMAX and AUC0-120 increased by 61% and 33% compared to normal patients. Patients with impaired liver function: No data shows a change in azithromycin level in plasma in a group of patients with medium and mild liver function compared to a group of patients with normal liver function. In this patient group, the recovery of azithromycin in the urethra seems to increase to compensate for the decrease in the liver's clearance.

Older patients: Azithromycin's pharmacokinetics in older patients are similar to that of a group of young patients; However, in the group of elderly female patients, although the peak concentration (an increase of about 30-50%), there is no significant accumulation.

Children: According to pharmacokinetic research in children from 4 months to 15 years of age when using drugs for capsules, nuggets or oral powder, taking a dose of 10 mg/kg on the first day and a dose of 5 mg/kg on the days from Monday to Thursday, CMAX concentration is not significant smaller than adults, in children from 0.6 to 5 years old and 3 days of cmax concentration µg/l for the group 6 - 15 years old. The last half -life (T1/2) in the older children's group is about 36 hours, this is an expectation of adults.

azithromycin through the placenta and distributed into the bloodstream, each other and amniotic fluid. Azithromycin is distributed into milk.

Before taking Glazi 250 Abbott treat acute sinusitis, acute otitis media, pharyngitis, tonsillitis (2 blisters x 6 tablets)

How to use

Glazi 250mg drug used orally, should take a single dose/day, can be taken with or not with food.

Dosage

Adults and children greater than 45kg:

Urethritis and cervicitis are uncomplicated due to chlamydia trachomatis: 1g a single dose.

Children under 45kg: Select other appropriate forms of azithromycin, for example: Movie.

Patients with renal insufficiency: No need to adjust the dose in patients with mild to medium to medium (GFR 10 - 80 ml/minute).

Patients with liver failure: No need to adjust the dose for patients with mild liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The typical overdose of macrolid antibiotics is often nausea, vomiting and diarrhea.

Handling: Mainly treating symptoms and support

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Glazi 250mg drugs often experience unwanted effects (ADR) such as:

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Infection: Candida fungus, vaginal infection, pneumonia, fungal infection, bacterial infection, sore throat, gastritis, respiratory disorders, rhinitis, oral fungal infection. Spirit: Anxiety, insomnia. swallowing, bloating, dry mouth, belching, mouth ulcers, increased salivation. weakness, fatigue, face, chest pain, fever, pain, peripheral edema.

Rare, ADR

Mental: anxiety.

Infection: fake colitis function. liver. Breathing.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Glazi 250mg drug contraindicated in the following cases:

Patients with a history of hypersensitivity to azithromycin, erythromycin, any antibiotic group macrolid or ketolid or any ingredient of the drug.

Be cautious when using

as well as antibiotics of macrolid group, azithromycin can cause serious allergic reactions such as vascular nerves.

extends the QT range that is at risk of arrhythmia when treated with macrolids, including azithromycin. Therefore, the following cases can lead to an increase in the risk of ventricular arrhythmia (which can lead to the heart -stopping heart), which should be cautious when using azithromycin in patients with cardiova Contract (especially women and the elderly), as the following cases:

There are data that shows that the patient has a QT or congenital interval.

Patients are being treated with other drugs that extend the QT range such as anti -arrhyths IA (Quinidin and Procainamid) and Group III (Dofetilide, Amiodaron and Sotalol), Cisaprid and Terfenadin, Anti -Psychotic Drugs such as Pimozide, Anti -Damage Drugs such as Citalopram and FluoroQuolonolon, such as Moxifinacin and MoxifinCin and MoxifinLon levofloxacin.

electrolyte disorders, especially cases of hypokalemia and hypoglycemia. Patients with bradycardia, arrhythmia or severe heart failure.

azithromycin is excreted mainly through the liver, so be careful when using azithromycin in patients with severe liver disease. Cases of violence can lead to life -threatening liver failure that has been reported to azithromycin.

In the case of signs and symptoms of liver dysfunction, such as rapid weakness develops related to jaundice, dark urine, the risk of bleeding or cerebral liver disease, liver function tests need to be conducted. Stop using azithromycin if liver dysfunction appears.

Disorders of liver, hepatitis, jaundice, liver necrosis and kidney failure have been reported and fatal in some cases. Stop using azithromycin if there are signs and symptoms of hepatitis.

In patients, the mushroom derivatives are used, the likelihood of poisoning of chicken spurs increases when used with a few macrolid antibiotics. There is no data on the ability to interact between chicken spurs and azithromycin. However, due to the ability to poison chicken spurs in theory, should not be used simultaneously these two drugs.

diarrhea related to Clostridium difficile (CDAD) has been reported to most antibiotics, including azithromycin, at a degree of mild diarrhea to colitis threatening life. Azithromycin can worsen myasthenia gravis, so it is recommended to take care of the medication in patients with myasthenia gravis.

Due to the risk of extending the QT, arrhythmia and torsion, caution should be used when using azithromycin in patients with a congenital or congenital QT range, or when used in combination with the drug that lasts a QT.

Monitor the signs of superinfection by bacteria that are not sensitive to drugs including fungi. 33% increase in contact of azithromycin on the body in patients with severe renal failure (GFR

The effect of the drug on driving and operating machinery

There is no evidence that azithromycin affects the ability to drive and operate the patient's machines. However, the side effects of the drug can cause dizziness, convulsions, so it should be noted when driving, operating machinery.

Use drugs for women during pregnancy and lactation

used for pregnant women: There is no adequate studies on pregnant women, so this drug is only for pregnant women if necessary.

Used for breastfeeding women: azithromycin is reported as excreted in breast milk, but there is no adequate clinical research and control in breastfeeding women in azithromycin dynamic properties in breast milk.

Because it is not known whether azithromycin will cause harmful effects on breastfeeding or not, should stop breastfeeding during treatment with azithromycin.

Drug interaction

Food: Food can hinder Azithromycin absorption.

Antacislets: When needed, azithromycin is only used at least 1 hour before or 2 hours after using antacids.

fluconazole can reduce the peak concentration (CMAX) of azithromycin by about 18%.

Nelfinavir may increase the concentration of azithromycin.

cimetidin: pharmacokinetics of azithromycin is not affected if taking a dose of cimetidin before using azithromycin 2 hours.

Conducting chicken fungus: Do not use simultaneously azithromycin with chicken spurs derivatives because of its ability to poison.

Digoxin: simultaneously use azithromycin and digoxin to increase the serum concentration of Digoxin. Therefore, it is necessary to evaluate serum digoxin concentration when using these two drugs simultaneously. Oral anticoagulants: simultaneously using azithromycin and oral anticoagulant can increase anticoagulant effects. Prothrombin should be monitored when using these 2 medications simultaneously.

cyclosporin: azithromycin can reduce the metabolism of cyclosporin, so it is necessary to monitor the concentration and adjust the dose of cyclosporin.

Theophylin: There has not been any effect on pharmacokinetics when 2 drugs azithromycin and theophylin are used in healthy volunteers, but generally should monitor theophylin concentration when using these two drugs for patients. Astemizol, Alfentanil: Be careful when using simultaneously Astemizol, Alfentanil with azithromycin because it is known that the concentration of these drugs increases when used simultaneously with erythromycin.

Atorvastatin: Musrophic globin has been reported in patients using azithromycin with statin.

Cisaprid: Cisaprid is metabolized in the liver by the CYP3A4 enzyme system. Because these enzyme inhibited macrolids should be used simultaneously with Cisaprid that can extend the QT interval, ventricular arrhythmia and torsion.

Zidovudine: Use a single dose of 1000mg and multi -1200mg or 600mg azithromycin dose that has a slightly affected pharmacokinetics in plasma and zidovudine excretion or glucuronic metabolism. However, using azithromycin increases the concentration of zidovudin phosphoryl, clinical metabolic metabolites, in peripheral blood cells. The clinical influence of this interaction is not clear, but can benefit the patient.

Rifabutin: Concomitant use of azithromycin and rifabutin does not affect the concentration of the drug in plasma. Despite the neutropenia related to the use of rifabutin, the cause related to the use in combination with azithromycin has not been set up.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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