Glomyl Glomed tablets treat acute, chronic oral infections (2 blisters x 10 tablets)

ATC code: J01RA04

Glogyl is a combination of Spiramycin and Metronidazol, which has a combination of energy against anaerobic and effective bacteria in the treatment of dental infections.

Spiramycin is an antibiotic macrolid with antibacterial spectrum similar to erythromycin. Spiramycin is inversely attached to the ribosom subunit, thereby preventing protein synthesis, and thus inhibits bacterial cell growth.

Metronidazole is a derivative of the 5-Nitroimidazol group that is active against anaerobic bacteria and protozoa.

The mechanism of action of Metronidazole is not very clear but may be involved in DNA intervention by a metabolic substance in which the nitro group of Metronidazol is reduced. This metabolic substance interacts with DNA to destroy the twisted structure of the DNA and thereby inhibit protein synthesis and kill the cells of sensitive bacteria.

pharmacokinetic

spiramycin

Spiramycin is not completely absorbed in the digestive tract. With a 6 M.I.U oral dose, the peak concentration in the blood is 3.3 micrograms/ml after 1.5-3 hours.

The ratio of binding to low plasma proteins (about 10%). Spiramycin is widely distributed throughout tissues such as lungs, tonsils, sinuses and bones. The drug reaches high concentrations and maintains for a long time in tissues even when plasma concentrations decrease, but few diffuse into the cerebrospinal fluid. The drug is distributed into breast milk.

Half life eliminates about 5-8 hours. Spiramycin is metabolized in the liver into active metabolites; Then excreted mainly in the bile and about 10% excreted in the urine.

metronidazol

Metronidazol is easily absorbed and almost completely after drinking. The peak concentration of plasma is about 6 mcg/ml and 12 mcg/ml usually achieved within 1-2 hours after using the single doses, respectively 250 mg and 500 mg respectively. The accumulation of drugs occurs with the concentration of an increase in the drug when using repeated doses.

Metronidazol is widely distributed. The drug is mostly present throughout the tissue and body fluid including bile, bone, breast milk, cerebrospinal fluid, liver, saliva, and vaginal discharge. The drug also passes the placenta and penetrates quickly during the fetal circulation. Under 20% of drugs associated with plasma proteins.

metronidazol is metabolized in the liver. The main oxidation metabolites are 1- (2-hydroxyethyl) -2-Hydroxymethyl-5-nitroimidazol (hydroxy metabolites), which are antibacterial and detected in plasma and urine, and 2-methyl-5-nitroimidazol-1-acetic acid (acid metabolism), this does not have antibacterial, and often detects in plasma effects But not excreted in urine. A small amount of reducing metabolites, acetamids and N- acids (2-hydroxyethyl) oxamic (flower), also found in urine.

Half lifetime elimination of Metronidazol is about 8 hours; Half -life elimination of hydroxy metabolites slightly longer. Half of the lifetime of metronidazol is longer in infants and patients with severe liver failure. A large percentage of the dose is excreted in urine mainly in the form of metabolites; A small amount appears in feces.

Be cautious when using

should be cautious when using Spiramycin for people with liver dysfunction.

Peripheral neuropathy, fleeting seizures, and leukemia occasionally occur when using high or prolonged metronidazol.

Patients should not drink alcohol while using Metronidazol because there may be disulfiram -style reactions.

Use drugs for women during pregnancy and nursing mothers

used for pregnant women: without adequate and controlled studies in pregnant women. Because animal fertility studies do not always predict human response, and due to metronidazol causing cancer for rodents, Glogyl should not be used during special pregnancy during the first 3 months of pregnancy.

Used for breastfeeding women: by Spiramycin and Metronidazol are excreted in breast milk, Glogyl is not recommended during breastfeeding.

The effect of the drug on the ability to control the train and operate machinery

Glogl does not affect the ability to control the train and operate machinery.

Medicinal interaction

spiramycin

Levodopa concentration in plasma decreases when used simultaneously with spiramycin.

Spiramycin reduces the effects of contraceptive drugs.

metronidazol

When taken with alcohol, Metronidazole can cause disulfiram -style reactions in some patients. Acute psychosis or confusion occurred when sharing metronidazol with disulfiram.

Metronidazol plasma concentrations are reduced by phenobarbital, resulting in a reduction in Metronidazol's effectiveness.

Metronidazol reduces the metabolism or elimination of some drugs including warfarin, phenytoin, lithium, ciclosporin, and fluorouracil, thereby increasing unwanted effects. Some evidence shows that phenytoin can increase the metabolism of Metronidazol.

cimetidine increases the plasma concentrations of metronidazol and may increase the risk of adverse effects on nerves.

metronidazol increases the effect of vecuronium.